scholarly journals Adverse effects of monosodium glutamate on the reproductive organs of adult Female albino rats and the possible ameliorated role of carob (Ceratonia Siliqua).

2016 ◽  
Vol 2 (3) ◽  
pp. 170-184
Author(s):  
Abd El-Fattah B. M. El-Beltagy ◽  
Heba Attef Elghaweet
2014 ◽  
Vol 27 (4) ◽  
pp. 793 ◽  
Author(s):  
MonaAbd El Mawla Mohammed Soliman ◽  
AhmedAbozaid Ali ◽  
GhadaHassan El-Seify ◽  
HalaMohammed El Haroun

Molecules ◽  
2020 ◽  
Vol 25 (11) ◽  
pp. 2633 ◽  
Author(s):  
Atef M.K. Nassar ◽  
Yehia M.M. Salim ◽  
Khalid S.A. Eid ◽  
Hazem M. Shaheen ◽  
Abdullah A. Saati ◽  
...  

Sumithion (Fenitrothion) (SUM) is an organophosphorus insecticide used to combat a wide variety of plant pests. Exposure to SUM causes significant toxicity to the brain, liver, kidney, and reproductive organs through, for example, binding to DNA, and it induces DNA damage, which ends with oxidative stress. Therefore, the present study aimed to examine the protective role of bee products: a mixture of honey, propolis, palm pollen, and royal jelly (HPPJ) against SUM-induced toxicity. Twenty-four male albino rats (Rattus norvegicus) were classified into four groups, each containing six rats: control (corn oil), SUM (85 mg/kg; 1/20 LD50), HPPJ, and SUM + HPPJ once daily for 28 consecutive days. Blood samples were gently collected in sterilized ethylenediaminetetraacetic acid (EDTA) tubes for blood picture analyses and tubes without anticoagulant for serum isolation. Serum was used for assays of enzymatic and biochemical characteristics. The results revealed that SUM increased the weights of the liver, kidney, and brain as well as the enzymatic activity of glutathione peroxidase (GP), serum superoxide dismutase (SOD), and glutathione-S-transferase (GST). Additionally, SUM significantly increased the activity of lactate dehydrogenase (LDH), alkaline phosphatase (ALP), and γ-glutamyltransferase (γ-GT) and glucose, uric acid, and creatinine contents, while decreasing the acetylcholine esterase (AChE) activity and total lipids and total protein content. Furthermore, because of the inclusion of phenolic, flavonoids, terpenoids, and sugars, the HPPJ mixture counteracted the hematological, renal, and hepatic toxicity of SUM exposure.


2013 ◽  
Vol 13 (4) ◽  
pp. 298-301 ◽  
Author(s):  
U.B. Ekaluo ◽  
E.V. Ikpeme ◽  
Y.B. Ibiang ◽  
O.S. Amaechina

2021 ◽  
Vol 70 ◽  
pp. 101502
Author(s):  
Hanan Fouad ◽  
Eman Mohamed Faruk ◽  
Wardah Abdullah Alasmari ◽  
Eman Hassan Nadwa ◽  
Usama Fouad Ahmed Ebrahim

Author(s):  
Ehab Tousson ◽  
Afaf El-Atrash ◽  
Yosra Karson

Background and Objective: Monosodium glutamate (MSG) is identified as an Accent that is used in the food industry as a flavour enhancer with an umami taste that intensifies the meaty, savoury flavour of food. The present study aimed at evaluating the protective and ameliorative role of rocket seeds extract against monosodium glutamate-induced hepatic renal toxicity and oxidative stress in the male rat. Materials and Methods: A total of 60 male adult albino rats were equally divided into six groups (G1, Control; G2, rocket seeds (RS); G3, ACCENT or MSG; G4, Co- treated (RS+MSG); G5, Post- treated (MSG+RS); G6, Self-treated MSG).  Results: Current results revealed that; a significant increase in serum ALT, AST, ALP, AFP, Urea, Creatinine, potassium ions, chloride ions, cholesterol, triglyceride, HDL, and LDL levels in MSG as compared to control and RS groups. In contrast; a significant decrease in serum albumin, total proteins, catalase, GSH and SOD in liver and kidney homogenates in MSG as compared to control and RS groups. Co- or post-treatment of MSG with rocket seeds improved this change in liver and kidney functions, with best results for co-treatment than post and self-treatment. Conclusion: These findings suggested that the misuse of monosodium glutamate may contribute to continuous hepatic and renal damage. This shows that the desired dose of monosodium glutamate can safely be used with grapes seed in improving hepatic and renal damage in monosodium glutamate in young rats.


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