IMMUNOCHEMICAL IDENTIFICATION OF Streptococcus pneumoniae 40 KDa ANTIGEN IN CEREBROSPINAL FLUID AND SERUM OF Streptococcus pneumoniae INFECTED PATIENTS

2011 ◽  
Vol 2 (1) ◽  
pp. 1-13
Author(s):  
E. M. El-Morsy ◽  
M. I. Abou-Dobara ◽  
M. M. Omran ◽  
M. A. El-Mansoury ◽  
A. M. Attallah
Keyword(s):  
Cerebrospinal Fluid ◽  
Streptococcus Pneumoniae ◽  
Immunochemical Identification

scholarly journals Use of a multiplexed immunoassay for detection of serotype-specific Streptococcus pneumoniae antigen in pleural fluid and cerebrospinal fluid specimens

2011 ◽  
Vol 60 (12) ◽  
pp. 1879-1881 ◽  
Author(s):  
Carmen L. Sheppard ◽  
Malcolm Guiver ◽  
John Hartley ◽  
Timothy G. Harrison ◽  
Robert C. George
Keyword(s):  
Cerebrospinal Fluid ◽  
Streptococcus Pneumoniae ◽  
Pleural Fluid ◽  
Multiplexed Immunoassay

scholarly journals Bactericidal activity against intermediately cephalosporin-resistant Streptococcus pneumoniae in cerebrospinal fluid of children with bacterial meningitis treated with high doses of cefotaxime and vancomycin.

1997 ◽  
Vol 41 (9) ◽  
pp. 2050-2052 ◽  
Author(s):  
C Doit ◽  
J Barre ◽  
R Cohen ◽  
S Bonacorsi ◽  
A Bourrillon ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Body Weight ◽  
Streptococcus Pneumoniae ◽  
Bacterial Meningitis ◽  
Bactericidal Activity ◽  
Additive Interaction ◽  
High Doses ◽  
Resistant Pneumococcus

Cerebrospinal fluid (CSF) was taken from 19 children with bacterial meningitis treated with cefotaxime (300 mg/kg of body weight/day) and vancomycin (60 mg/kg/day). Median levels of drugs in CSF were smaller than expected, as follows: 4.4 microg/ml for cefotaxime, 3.2 microg/ml for desacetylcefotaxime, and 1.7 microg/ml for vancomycin. The median CSF bactericidal titer against an intermediately cefotaxime-resistant pneumococcus was 1:4. Our data suggest at least an additive interaction between the drugs used in this study.

scholarly journals Parainfectious vasculitis due to Pneumococcal meningitis following traumatic CSF rhinorrhoea resulting in cerebellar infarction

2020 ◽  
Vol 11 (4) ◽  
pp. 102-105
Author(s):  
Ummer Karadan ◽  
Robin George Manappallil ◽  
Manoj Bhaskaran ◽  
Anoop Chandran ◽  
Ivin Panakkel Zacharia
Keyword(s):  
Cerebrospinal Fluid ◽  
Streptococcus Pneumoniae ◽  
Pneumococcal Meningitis ◽  
Cribriform Plate ◽  
Cerebellar Infarction ◽  
Traumatic Fracture ◽  
Life Threatening ◽  
Csf Rhinorrhoea ◽  
Life Threatening Complication

Parainfectious vasculitis is a rare life threatening complication of Streptococcus pneumoniae (S.pneumoniae) meningitis. There is a 19% risk of developing meningitis in the patients with cerebrospinal fluid (CSF) rhinorrhoea. The patient being reported developed CSF rhinorrhoea due to traumatic fracture of cribriform plate, followed by pneumococcal meningitis and parainfectious vasculitis resulting in cerebellar infarction.

scholarly journals Gemifloxacin Is Effective in Experimental Pneumococcal Meningitis

2000 ◽  
Vol 44 (3) ◽  
pp. 767-770 ◽  
Author(s):  
A. Smirnov ◽  
A. Wellmer ◽  
J. Gerber ◽  
K. Maier ◽  
S. Henne ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Streptococcus Pneumoniae ◽  
Standard Deviation ◽  
Pneumococcal Meningitis ◽  
Rabbit Model ◽  
Csf Levels ◽  
Experimental Pneumococcal Meningitis

ABSTRACT In a rabbit model of Streptococcus pneumoniaemeningitis, 5 mg of gemifloxacin mesylate (SB-265805) per kg/h reduced the bacterial titers in cerebrospinal fluid (CSF) almost as rapidly as 10 mg of ceftriaxone per kg/h (Δlog CFU/ml/h ± standard deviation [SD], −0.25 ± 0.09 versus −0.38 ± 0.11; serum and CSF concentrations of gemifloxacin were 2.1 ± 1.4 mg/liter and 0.59 ± 0.38 mg/liter, respectively, at 24 h). Coadministration of 1 mg of dexamethasone per kg did not affect gemifloxacin serum and CSF levels (2.7 ± 1.4 mg/liter and 0.75 ± 0.34 mg/liter, respectively, at 24 h) or activity (Δlog CFU/ml/h ± SD, −0.26 ± 0.11).

scholarly journals Genetic Relationship between Streptococcus pneumoniae Isolates from Nasopharyngeal and Cerebrospinal Fluid of Two Infants with Pneumococcal Meningitis

2003 ◽  
Vol 41 (8) ◽  
pp. 3970-3972 ◽  
Author(s):  
A. L. S. S. de Andrade ◽  
F. C. Pimenta ◽  
M. C. C. Brandileone ◽  
C. A. Laval ◽  
M. L. Guerra ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Streptococcus Pneumoniae ◽  
Genetic Relationship ◽  
Pneumococcal Meningitis

A triad of endocarditis, endophthalmitis, and meningitis

Open Medicine ◽  
2013 ◽  
Vol 8 (6) ◽  
pp. 795-798
Author(s):  
Aušra Kavoliūnienė ◽  
Regina Jonkaitienė ◽  
Laura Urbonaitė
Keyword(s):  
Cerebrospinal Fluid ◽  
Streptococcus Pneumoniae ◽  
Infective Endocarditis ◽  
Mortality Rate ◽  
Aortic Valve ◽  
Aortic Valve Replacement ◽  
Transesophageal Echocardiography ◽  
Rare Case ◽  
Antibacterial Treatment ◽  
Infective Complications

AbstractStreptococcus pneumoniae is an uncommon cause of infective endocarditis; it often requires prolonged antibacterial treatment and involves a high mortality rate. We report a rare case of pneumococcal endocarditis manifesting with unusual complications — meningitis and endophthalmitis. Streptococcus pneumoniae species grew from the cerebrospinal fluid. The diagnosis of native aortic valve infective endocarditis was confirmed after some delay by transesophageal echocardiography. The patient’s eye was lost because of infective complications, but his life was saved following an aggressive antibacterial therapy in combination with an immediate aortic valve replacement.

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