scholarly journals THE IMPACT OF CYCLOOXYGENASE-2 GENE POLYMORPHISM 899G/C AND CERTAIN INDICES ON HEPATITIS C RELATED LIVER FIBROSIS

2019 ◽  
Vol 37 (1) ◽  
pp. 37-60
Keyword(s):  
Hepatitis C ◽  
Liver Fibrosis ◽  
Gene Polymorphism ◽  
Cyclooxygenase 2 ◽  
The Impact

The impact of direct-acting antivirals on liver fibrosis in Egyptian hepatitis C virus patients: a single center experience

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Nadia Abdelaaty Abdelkader ◽  
Amira Mahmoud AlBalakosy ◽  
Ahmed Fouad Helmy Sherief ◽  
Mohamed Soliman Gado
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Liver Fibrosis ◽  
Transient Elastography ◽  
Liver Stiffness ◽  
Treatment Unit ◽  
Non Invasive ◽  
One Year ◽  
The Impact

Abstract Background Hepatitis C virus (HCV) infection affects approximately 170 million people worldwide, causing liver cirrhosis and hepatocellular carcinoma (HCC) and leading to liver transplantation and ultimately death. Accurate evaluation of liver fibrosis in patients with chronic liver diseases is crucial, as liver fibrosis is important in order to make therapeutic decisions, determine prognosis of liver disease and to follow-up disease progression. Multiple non-invasive methods have been used successfully in the prediction of fibrosis; however, early changes in noninvasive biomarkers of hepatic fibrosis under effective antiviral therapy are widely unknown. The aim of this study is to evaluate changes of transient elastography values as well as FIB-4 and AST to platelet ratio index (APRI) in patients treated with DAAs. Objectives The aim beyond this study is to evaluate the changes in liver stiffness in hepatitis C Egyptian patients before and at least one year after treatment with DAAs using transient elastography and non-invasive liver fibrosis indices as FIB-4 and APRI scores. Patients and methods The present study was conducted on 100 patients with chronic hepatitis C patients attended to Ain Shams University Hospitals, Viral hepatitis treatment unit between October 2017 and December 2018, who were followed-up during treatment and after treatment for at least one year (retrospective and prospective study). Total number of cases during the study period was 117 patients. 17 patients were excluded from the study due to missed follow-up. Eventually, 100 patients were enrolled in the study fulfilling the inclusion criteria. Results The mean age of our patients is 47.9 years with Male predominance (52 males and 48 females). There was a significant improvement of, platelets counts, ALT and AST levels, which in turn cause significant improvement in FIB-4 and APRI scores. There was a significant improvement of liver stiffness after end of treatment, regardless of the DAA regimen used, as evidenced by Fibroscan. Conclusion Fibrosis regression –assessed by non-invasive markers of fibrosis is achievable upon removal of the causative agent.

scholarly journals Hepatitis C Virus Core Protein Suppresses NF-κB Activation and Cyclooxygenase-2 Expression by Direct Interaction with IκB Kinase β

2005 ◽  
Vol 79 (12) ◽  
pp. 7648-7657 ◽  
Author(s):  
Myungsoo Joo ◽  
Young S. Hahn ◽  
Minjae Kwon ◽  
Ruxana T. Sadikot ◽  
Timothy S. Blackwell ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Nuclear Translocation ◽  
Core Protein ◽  
Ectopic Expression ◽  
Cyclooxygenase 2 ◽  
Necrosis Factor Alpha ◽  
Iκb Kinase ◽  
Cox 2 ◽  
The Impact

ABSTRACT In addition to hepatocytes, hepatitis C virus (HCV) infects immune cells, including macrophages. However, little is known concerning the impact of HCV infection on cellular functions of these immune effector cells. Lipopolysaccharide (LPS) activates IκB kinase (IKK) signalsome and NF-κB, which leads to the expression of cyclooxygenase-2 (COX-2), which catalyzes production of prostaglandins, potent effectors on inflammation and possibly hepatitis. Here, we examined whether expression of HCV core interferes with IKK signalsome activity and COX-2 expression in activated macrophages. In reporter assays, HCV core inhibited NF-κB activation in RAW 264.7 and MH-S murine macrophage cell lines treated with bacterial LPS. HCV core inhibited IKK signalsome and IKKβ kinase activities induced by tumor necrosis factor alpha in HeLa cells and coexpressed IKKγ in 293 cells, respectively. HCV core was coprecipitated with IΚΚβ and prevented nuclear translocation of IKKβ. NF-κB activation by either LPS or overexpression of IKKβ was sufficient to induce robust expression of COX-2, which was markedly suppressed by ectopic expression of HCV core. Together, these data indicate that HCV core suppresses IKK signalsome activity, which blunts COX-2 expression in macrophages. Additional studies are necessary to determine whether interrupted COX-2 expression by HCV core contributes to HCV pathogenesis.

The impact of direct antiviral agent therapy on liver fibrosis in patient with advanced fibrosis related chronic hepatitis C

2018 ◽  
Vol 68 ◽  
pp. S541 ◽  
Author(s):  
B. Kutala ◽  
N.B. Darrigrand ◽  
C. Corinne ◽  
B. Pierre ◽  
T. Asselah ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Liver Fibrosis ◽  
Chronic Hepatitis C ◽  
Antiviral Agent ◽  
Advanced Fibrosis ◽  
The Impact

Can NLRP3 gene polymorphism in Egyptian chronic hepatitis C patients affect the degree of liver fibrosis?

2015 ◽  
Vol 2 (3) ◽  
pp. 116-122
Author(s):  
Shady Z. K. Estfanous ◽  
◽  
Sameh M Seif ◽  
Sameh H. A. Soror ◽  
Dalia H. A. Abdelaziz ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Liver Fibrosis ◽  
Gene Polymorphism ◽  
Chronic Hepatitis C ◽  
Nlrp3 Gene ◽  
Chronic Hepatitis C Patients

Modeling the impact of interferon alfa treatment on liver fibrosis progression in chronic hepatitis C: A dynamic view

1999 ◽  
Vol 116 (2) ◽  
pp. 378-386 ◽  
Author(s):  
Rodolphe Sobesky ◽  
Philippe Mathurin ◽  
Frederic Charlotte ◽  
Joseph Moussalli ◽  
Martine Olivi ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Liver Fibrosis ◽  
Chronic Hepatitis C ◽  
Interferon Alfa ◽  
Fibrosis Progression ◽  
Dynamic View ◽  
The Impact

scholarly journals The Impact of IL28B Genotype and Liver Fibrosis on the Hepatic Expression of IP10, IFI27, ISG15, and MX1 and Their Association with Treatment Outcomes in Patients with Chronic Hepatitis C

PLoS ONE ◽  
2015 ◽  
Vol 10 (6) ◽  
pp. e0130899 ◽  
Author(s):  
Krzysztof Domagalski ◽  
Małgorzata Pawłowska ◽  
Dorota Kozielewicz ◽  
Dorota Dybowska ◽  
Andrzej Tretyn ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Liver Fibrosis ◽  
Treatment Outcomes ◽  
Chronic Hepatitis C ◽  
Il28b Genotype ◽  
Hepatic Expression ◽  
The Impact
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