scholarly journals EVALUATION OF RECEPTOR FOR ADVANCED GLYCATION END PRODUCT /HIGH-MOBILITY GROUP BOX 1 (RAGE/HMGB1) EXPRESSION STATUS AND ITS PROGNOSTIC VALUE IN BREAST CANCER

2019 ◽  
Vol 37 (1) ◽  
pp. 17-36
Keyword(s):  
Breast Cancer ◽  
Prognostic Value ◽  
High Mobility ◽  
High Mobility Group ◽  
Advanced Glycation ◽  
Advanced Glycation End Product ◽  
Hmgb1 Expression ◽  
Expression Status

scholarly journals Translating Proteomic Into Functional Data: An High Mobility Group A1 (HMGA1) Proteomic Signature Has Prognostic Value in Breast Cancer

2015 ◽  
Vol 15 (1) ◽  
pp. 109-123 ◽  
Author(s):  
Elisa Maurizio ◽  
Jacek R. Wiśniewski ◽  
Yari Ciani ◽  
Angela Amato ◽  
Laura Arnoldo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Functional Data ◽  
Prognostic Value ◽  
High Mobility ◽  
High Mobility Group

scholarly journals Overexpression of Receptor for Advanced Glycation End Products and High-Mobility Group Box 1 in Human Dental Pulp Inflammation

2014 ◽  
Vol 2014 ◽  
pp. 1-13 ◽  
Author(s):  
Salunya Tancharoen ◽  
Tassanee Tengrungsun ◽  
Theeralaksna Suddhasthira ◽  
Kiyoshi Kikuchi ◽  
Nuttavun Vechvongvan ◽  
...  
Keyword(s):  
Advanced Glycation End Products ◽  
Dental Pulp ◽  
High Mobility ◽  
High Mobility Group ◽  
Dependent Manner ◽  
Advanced Glycation ◽  
Pulp Inflammation ◽  
Glycation End Products ◽  
End Products ◽  
Hmgb1 Expression

High mobility group box 1 (HMGB1), a nonhistone DNA-binding protein, is released into the extracellular space and promotes inflammation. HMGB1 binds to related cell signaling transduction receptors, including receptor for advanced glycation end products (RAGE), which actively participate in vascular and inflammatory diseases. The aim of this study was to examine whether RAGE and HMGB1 are involved in the pathogenesis of pulpitis and investigate the effect of Prevotella intermedia (P. intermedia) lipopolysaccharide (LPS) on RAGE and HMGB1 expression in odontoblast-like cells (OLC-1). RAGE and HMGB1 expression levels in clinically inflamed dental pulp were higher than those in healthy dental pulp. Upregulated expression of RAGE was observed in odontoblasts, stromal pulp fibroblasts-like cells, and endothelial-like cell lining human pulpitis tissue. Strong cytoplasmic HMGB1 immunoreactivity was noted in odontoblasts, whereas nuclear HMGB1 immunoreactivity was seen in stromal pulp fibroblasts-like cells in human pulpitis tissue. LPS stimulated OLC-1 cells produced HMGB1 in a dose-dependent manner through RAGE. HMGB1 translocation towards the cytoplasm and secretion from OLC-1 in response to LPS was inhibited by TPCA-1, an inhibitor of NF-κB activation. These findings suggest that RAGE and HMGB1 play an important role in the pulpal immune response to oral bacterial infection.

scholarly journals High-mobility group box-1 protein from CC10+ club cells promotes type 2 response in the later stage of respiratory syncytial virus infection

2019 ◽  
Vol 316 (1) ◽  
pp. L280-L290 ◽  
Author(s):  
Sisi Chen ◽  
Guangyuan Yu ◽  
Jun Xie ◽  
Wei Tang ◽  
Leiqiong Gao ◽  
...  
Keyword(s):  
Respiratory Syncytial Virus ◽  
High Mobility ◽  
Clinical Severity ◽  
High Mobility Group ◽  
Hmgb1 Protein ◽  
Club Cells ◽  
Hmgb1 Expression ◽  
Syncytial Virus ◽  
Tract Infections

The type 2 immune response, induced by infection of respiratory syncytial virus (RSV), has been linked to asthma development, but it remains unclear how the response is initiated. Here, we reported that the high-mobility group box-1 (HMGB1) protein promotes the type 2 response in the later stage of RSV infection. In mice, we found that type 2 cytokines were elevated in the later stages, which were strongly diminished after administration of anti-HMGB1 antibodies. Further investigation revealed that HMGB1 expression was localized to CC10+ club cells in the lung. In the clinic, levels of HMGB1 in nasopharyngeal aspirates in hospitalized infants with RSV bronchiolitis [median (interquartile range) 161.20 ng/ml (68.06–221.30)] were significantly higher than those without lower respiratory tract infections [21.94 ng/ml (12.12–59.82); P < 0.001]. Moreover, higher levels of HMGB1 correlated with clinical severity. These results reveal a link between viral infection and the asthma-like type 2 responses that are associated with long-term consequences.

scholarly journals High Mobility Group Box 1 Protein in Cerebral Thromboemboli

2021 ◽  
Vol 22 (20) ◽  
pp. 11276
Author(s):  
Fabian Essig ◽  
Lilith Babilon ◽  
Christoph Vollmuth ◽  
Alexander M. Kollikowski ◽  
Mirko Pham ◽  
...  
Keyword(s):  
Mechanical Thrombectomy ◽  
High Mobility ◽  
Large Vessel ◽  
High Mobility Group ◽  
Neutrophil Extracellular Trap ◽  
Spatial Proximity ◽  
Large Vessel Occlusion ◽  
Vessel Occlusion ◽  
Molecular Pattern ◽  
Hmgb1 Expression

High-mobility group box 1 protein (HMGB1) is a damage-associated molecular pattern (DAMP) involved in neutrophil extracellular trap (NET) formation and thrombosis. NETs are regularly found in cerebral thromboemboli. We here analyzed associated HMGB1 expression in human thromboemboli retrieved via mechanical thrombectomy from 37 stroke patients with large vessel occlusion. HMGB1 was detected in all thromboemboli, accounting for 1.7% (IQR 0.6–6.2%) of the total thromboemboli area and was found to be colocalized with neutrophils and NETs and in spatial proximity to platelets. Correlation analysis revealed that the detection of HMGB1 was strongly related to the number of neutrophils (r = 0.58, p = 0.0002) and platelets (r = 0.51, p = 0.001). Our results demonstrate that HMGB1 is a substantial constituent of thromboemboli causing large vessel occlusion stroke.

High mobility group A1 (HMGA1) protein and gene expression correlate with ER-negativity and poor outcomes in breast cancer

2019 ◽  
Vol 179 (1) ◽  
pp. 25-35 ◽  
Author(s):  
Mikhail Gorbounov ◽  
Neil M. Carleton ◽  
Rebecca J. Asch-Kendrick ◽  
Lingling Xian ◽  
Lisa Rooper ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
High Mobility ◽  
High Mobility Group ◽  
Poor Outcomes
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