scholarly journals The Potential Protective Effect of Spirulina Platensis against Mycotoxin Induced Oxidative Stress and Liver Damage in Rats

2018 ◽  
Vol 35 (2) ◽  
pp. 375-383
Author(s):  
S.A Hussein ◽  
O.M Abd el-hamid ◽  
O.S El-tawil ◽  
E.S Laz ◽  
W.M Taha
Keyword(s):  
Oxidative Stress ◽  
Protective Effect ◽  
Liver Damage ◽  
Spirulina Platensis

scholarly journals Protective Action of Antioxidants on Hepatic Damage Induced by Griseofulvin

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
M. del C. Martinez ◽  
S. G. Afonso ◽  
A. M. Buzaleh ◽  
A. Batlle
Keyword(s):  
Oxidative Stress ◽  
Protective Effect ◽  
Liver Damage ◽  
Protective Action ◽  
Protoporphyrin Ix ◽  
Antioxidant Defense System ◽  
Cellular Damage ◽  
Antioxidant Compounds ◽  
Stress Markers ◽  
Heme Regulation

Erythropoietic protoporphyria (EPP) is a disease associated with ferrochelatase deficiency and characterized by the accumulation of protoporphyrin IX (PROTO IX) in erythrocytes, liver, and skin. In some cases, a severe hepatic failure and cholestasis were observed. Griseofulvin (Gris) develops an experimental EPP with hepatic manifestations in mice such as PROTO IX accumulation followed by cellular damage as wells as necrotic and inflammatory processes. The antioxidant defense system was also altered. The aim was to evaluate the possible protective effect of different antioxidant compounds: trolox (Tx), ascorbic acid (Asc), the combination Tx and Asc, melatonin (Mel), and the polyphenols: ellagic acid, quercetin, chlorogenic acid, caffeic acid, gallic acid, and ferulic acid on liver damage and oxidative stress markers in a mouse model of EPP. Coadministration of Gris with Tx, Asc, and its combination, or Mel mainly affected heme biosynthetic pathway, resulting in a decrease in ALA-S activity which was increased by Gris, while the tested polyphenols exerted a protective effect on oxidative stress, decreasing lipid peroxidation and the activity of some antioxidant enzymes. In conclusion, antioxidant compounds can only protect partially against the liver damage induced by Gris, reducing oxidative stress or acting on heme regulation.

scholarly journals Protective effect of a phytocompound on oxidative stress and DNA fragmentation against paracetamol-induced liver damage

2009 ◽  
Vol 8 (1) ◽  
pp. 50-56 ◽  
Author(s):  
Francesco Marotta ◽  
Hariom Yadav ◽  
Upendra Gumaste ◽  
A.m.r. Helmy ◽  
Shalini Jain ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Protective Effect ◽  
Dna Fragmentation ◽  
Liver Damage

Protective effect of Indian honey on acetaminophen induced oxidative stress and liver toxicity in rat

Biologia ◽  
2009 ◽  
Vol 64 (6) ◽  
Author(s):  
Ayyavu Mahesh ◽  
Jabbith Shaheetha ◽  
Devarajan Thangadurai ◽  
Dowlathabad Muralidhara Rao
Keyword(s):  
Oxidative Stress ◽  
Protective Effect ◽  
Liver Damage ◽  
Total Bilirubin ◽  
Liver Toxicity ◽  
Total Bilirubin Level ◽  
Serum Levels ◽  
Hepatoprotective Activity ◽  
Natural Medicine ◽  
Enzyme Markers

AbstractThe present study was undertaken to investigate the protective effect of Indian honey on acetaminophen induced oxidative stress and liver damage in rat. Honey serves as a source of natural medicine, which is effective to reducing the risk of heart disease, liver toxicity and inflammatory processes. The hepatoprotective activity of the Indian honey was determined by assessing levels of Serum transaminases, ALP and total bilirubin. Finally, the effects of the test substances on the antioxidant enzymes of the liver were also studied by assessing changes in the level of reduced glutathione, glutathione peroxidase, catalase and superoxide dismutase. Serum transaminase, ALP and total bilirubin level were significantly elevated and the antioxidant status in liver such as activities of SOD, CAT, GPx and the levels of GSH were declined significantly in APAP alone treated animals. Pretreatment with honey and silymarin prior to the administration of APAP significantly prevented the increase in the serum levels of hepatic enzyme markers and reduced oxidative stress. The histopathological evaluation of the livers also revealed that honey reduced the incidence of liver lesions induced by APAP. Results suggest that the Indian honey protects liver against oxidative damage and it could be used as an effective hepatoprotector against APAP induced liver damage.

Antioxidant Activity and Protective Effect against Oxidative Stress on Hippocampal HT22 Cells of Tea Seed Oil

2018 ◽  
Vol 24 (1) ◽  
pp. 53-59
Author(s):  
Jong Min Kim ◽  
Seon Kyeong Park ◽  
Jin Yong Kang ◽  
Seong-kyeong Bae ◽  
Ga-Hee Jeong ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Activity ◽  
Protective Effect ◽  
Seed Oil ◽  
Ht22 Cells ◽  
Tea Seed Oil

Protective effect of DJ-1 against oxidative stress: an advance

2012 ◽  
Vol 32 (1) ◽  
pp. 88-91
Author(s):  
Zhi-yong WANG ◽  
Ling-zhen TANG ◽  
Tian-wen GAO
Keyword(s):  
Oxidative Stress ◽  
Protective Effect

Protective Effect of Swertiamarin on Myocardial Injury Through Activation of Nrf2/HO-1 Pathway in Heart Failure Model of Rats

2020 ◽  
Vol 18 (3) ◽  
pp. 260-265
Author(s):  
Xu Lin ◽  
Zheng Xiaojun ◽  
Lv Heng ◽  
Mo Yipeng ◽  
Tong Hong
Keyword(s):  
Oxidative Stress ◽  
Heart Failure ◽  
Ejection Fraction ◽  
Protective Effect ◽  
Infarct Size ◽  
Rat Model ◽  
Left Ventricular ◽  
Related Factor ◽  
Nuclear Factor ◽  
Internal Dimension

The purpose of this study was to evaluate the protective effect of swertiamarin on heart failure. To this end, a rat model of heart failure was established via left coronary artery ligation. Infarct size of heart tissues was determined using triphenyl tetrazolium chloride staining. Echocardiography was performed to evaluate cardiac function by the determination of ejection fraction, left ventricular internal dimension in diastole and left ventricular internal dimension in systole. The effect of swertiamarin on oxidative stress was evaluated via enzyme-linked immunosorbent assay. The mechanism was evaluated using western blot. Administration of swertiamarin reduced the infarct size of heart tissues in rat models with heart failure. Moreover, swertiamarin treatment ameliorated the cardiac function, increased ejection fraction and fractional shortening, decreased left ventricular internal dimension in diastole and left ventricular internal dimension in systole. Swertiamarin improved oxidative stress with reduced malondialdehyde, while increased superoxide dismutase, glutathione, and GSH peroxidase. Furthermore, nuclear-factor erythroid 2-related factor 2, heme oxygenase and NAD(P)H dehydrogenase (quinone 1) were elevated by swertiamarin treatment in heart tissues of rat model with heart failure. Swertiamarin alleviated heart failure through suppression of oxidative stress response via nuclear-factor erythroid 2-related factor 2/heme oxygenase-1 pathway providing a novel therapeutic strategy for heart failure.

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