scholarly journals Trial for Preparation of Combined Equine Influenza virus, Equine Herpesvirus-1 and Tetanus Toxoid Vaccine

2018 ◽  
Vol 34 (1) ◽  
pp. 106-116
Author(s):  
Mohamed bayoumi ◽  
Abdelmoneim Moustafa ◽  
Nashwa Madkour ◽  
Abdelfattah Selim ◽  
Wafaa Abdelazez
Keyword(s):  
Influenza Virus ◽  
Tetanus Toxoid ◽  
Equine Herpesvirus ◽  
Equine Influenza Virus ◽  
Equine Herpesvirus 1 ◽  
Equine Influenza ◽  
Herpesvirus 1

scholarly journals Trials For Preparation Of Combined Vaccine Of Equine Influenza, Equine Herpesvirus–1, Rabies Virus And Tetanus Toxoid

2021 ◽  
Vol 6 (1) ◽  
pp. 38-44
Author(s):  
Safaa A. Warda ◽  
wafaa abdelaziz ◽  
Eman M. Ebied ◽  
Nashwa K. Madkour ◽  
Hala El Sawy ◽  
...  
Keyword(s):  
Rabies Virus ◽  
Tetanus Toxoid ◽  
Equine Herpesvirus ◽  
Equine Herpesvirus 1 ◽  
Equine Influenza ◽  
Herpesvirus 1 ◽  
Combined Vaccine

scholarly journals Field Evaluation of the prepared combined equine influenza, equine herpesvirus-1 and tetanus toxoid vaccine in horses

2018 ◽  
Vol 34 (1) ◽  
pp. 289-299
Author(s):  
Mohamed Bayoumi ◽  
Abdelfattah Selim ◽  
Abdelmoneim Moustafa ◽  
Nashwa Madkour ◽  
H El-Helw
Keyword(s):  
Tetanus Toxoid ◽  
Field Evaluation ◽  
Equine Herpesvirus ◽  
Equine Herpesvirus 1 ◽  
Equine Influenza ◽  
Herpesvirus 1

An equine herpesvirus 1 (EHV-1) vectored H1 vaccine protects against challenge with swine-origin influenza virus H1N1

2011 ◽  
Vol 154 (1-2) ◽  
pp. 113-123 ◽  
Author(s):  
Abdelrahman Said ◽  
Armando Damiani ◽  
Guanggang Ma ◽  
Donata Kalthoff ◽  
Martin Beer ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Equine Herpesvirus ◽  
Virus H1n1 ◽  
Equine Herpesvirus 1 ◽  
Herpesvirus 1

scholarly journals A Live-Attenuated Equine Influenza Vaccine Stimulates Innate Immunity in Equine Respiratory Epithelial Cell Cultures That Could Provide Protection From Equine Herpesvirus 1

2021 ◽  
Vol 8 ◽  
Author(s):  
Lila M. Zarski ◽  
Wendy E. Vaala ◽  
D. Craig Barnett ◽  
Fairfield T. Bain ◽  
Gisela Soboll Hussey
Keyword(s):  
Innate Immunity ◽  
Influenza Vaccine ◽  
Equine Herpesvirus ◽  
Equine Herpesvirus 1 ◽  
Equine Influenza ◽  
Antiviral Responses ◽  
Herpesvirus 1 ◽  
Antiviral Innate Immunity ◽  
Respiratory Epithelial

Equine herpesvirus 1 (EHV-1) ubiquitously infects horses worldwide and causes respiratory disease, abortion, and equine herpesvirus myeloencephalopathy. Protection against EHV-1 disease is elusive due to establishment of latency and immune-modulatory features of the virus. These include the modulation of interferons, cytokines, chemokines, antigen presentation, and cellular immunity. Because the modulation of immunity likely occurs at the site of first infection—the respiratory epithelium, we hypothesized that the mucosal influenza vaccine Flu Avert® I.N. (Flu Avert), which is known to stimulate strong antiviral responses, will enhance antiviral innate immunity, and that these responses would also provide protection from EHV-1 infection. To test our hypothesis, primary equine respiratory epithelial cells (ERECs) were treated with Flu Avert, and innate immunity was evaluated for 10 days following treatment. The timing of Flu Avert treatment was also evaluated for optimal effectiveness to reduce EHV-1 replication by modulating early immune responses to EHV-1. The induction of interferons, cytokine and chemokine mRNA expression, and protein secretion was evaluated by high-throughput qPCR and multiplex protein analysis. Intracellular and extracellular EHV-1 titers were determined by qPCR. Flu Avert treatment resulted in the modulation of IL-8, CCL2, and CXCL9 starting at days 5 and 6 post-treatment. Coinciding with the timing of optimal chemokine induction, our data also suggested the same timing for reduction of EHV-1 replication. In combination, our results suggest that Flu Avert may be effective at counteracting some of the immune-modulatory properties of EHV-1 at the airway epithelium and the peak for this response occurs 5–8 days post-Flu Avert treatment. Future in vivo studies are needed to investigate Flu Avert as a prophylactic in situations where EHV-1 exposure may occur.

A vectored equine herpesvirus type 1 (EHV-1) vaccine elicits protective immune responses against EHV-1 and H3N8 equine influenza virus

Vaccine ◽  
2010 ◽  
Vol 28 (4) ◽  
pp. 1048-1055 ◽  
Author(s):  
Gerlinde R. Van de Walle ◽  
Maeva A. May ◽  
Sarah T. Peters ◽  
Stephan M. Metzger ◽  
Cristina T. Rosas ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Immune Responses ◽  
Equine Herpesvirus ◽  
Equine Influenza Virus ◽  
Herpesvirus Type ◽  
Equine Influenza ◽  
Equine Herpesvirus Type ◽  
Equine Herpesvirus Type 1
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