scholarly journals In Vitro Study of Anticancer Effect of N Acetyl Cysteine –Metal Complexes as New Target Drugs on Human Cancer Cell Lines

2018 ◽  
Vol 34 (3) ◽  
pp. 206-217
Author(s):  
Omayma A. R. AbouZaid ◽  
Eman Noaman ◽  
Shaimaa abdelAti ◽  
Gehad Mohamed
Keyword(s):  
Metal Complexes ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
In Vitro Study ◽  
Cancer Cell Lines ◽  
Human Cancer Cell ◽  
Anticancer Effect ◽  
Human Cancer Cell Lines

scholarly journals PP118—In vitro study of sonodynamic and photodynamic treatment on human cancer cell lines

2013 ◽  
Vol 35 (8) ◽  
pp. e51-e52 ◽  
Author(s):  
F. Foglietta ◽  
R. Canaparo ◽  
A. Francovich ◽  
P. Civera ◽  
L. Serpe
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
In Vitro Study ◽  
Cancer Cell Lines ◽  
Vitro Study ◽  
Human Cancer Cell ◽  
Photodynamic Treatment ◽  
Human Cancer Cell Lines

Synergistic anticancer activity of curcumin and catechin: An in vitro study using human cancer cell lines

2011 ◽  
Vol 75 (2) ◽  
pp. 112-116 ◽  
Author(s):  
R. Manikandan ◽  
M. Beulaja ◽  
C. Arulvasu ◽  
S. Sellamuthu ◽  
D. Dinesh ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
In Vitro Study ◽  
Cancer Cell Lines ◽  
Vitro Study ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines

scholarly journals Discovery of New Pyrazolopyridine, Furopyridine, and Pyridine Derivatives as CDK2 Inhibitors: Design, Synthesis, Docking Studies, and Anti-Proliferative Activity

Molecules ◽  
2021 ◽  
Vol 26 (13) ◽  
pp. 3923
Author(s):  
Adel A.-H. Abdel-Rahman ◽  
Amira K. F. Shaban ◽  
Ibrahim F. Nassar ◽  
Dina S. EL-Kady ◽  
Nasser S. M. Ismail ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Human Cancer Cell ◽  
Molecular Docking Study ◽  
Human Cancer Cell Lines ◽  
Hct 116 ◽  
Mcf 7

New pyridine, pyrazoloyridine, and furopyridine derivatives substituted with naphthyl and thienyl moieties were designed and synthesized starting from 6-(naphthalen-2-yl)-2-oxo-4-(thiophen-2-yl)-1,2-dihydropyridine-3-carbonitrile (1). The chloro, methoxy, cholroacetoxy, imidazolyl, azide, and arylamino derivatives were prepared to obtain the pyridine-−C2 functionalized derivatives. The derived pyrazolpyridine-N-glycosides were synthesized via heterocyclization of the C2-thioxopyridine derivative followed by glycosylation using glucose and galactose. The furopyridine derivative 14 and the tricyclic pyrido[3′,2′:4,5]furo[3,2-d]pyrimidine 15 were prepared via heterocyclization of the ester derivative followed by a reaction with formamide. The newly synthesized compounds were evaluated for their ability to in vitro inhibit the CDK2 enzyme. In addition, the cytotoxicity of the compounds was tested against four different human cancer cell lines (HCT-116, MCF-7, HepG2, and A549). The CDK2/cyclin A2 enzyme inhibitory results revealed that pyridone 1, 2-chloro-6-(naphthalen-2-yl)-4-(thiophen-2-yl)nicotinonitrile (4), 6-(naphthalen-2-yl)-4-(thiophen-2-yl)-1H-pyrazolo[3,4-b]pyridin-3-amine (8), S-(3-cyano-6-(naphthaen-2-yl)-4-(thiophen-2-yl)pyridin-2-yl) 2-chloroethanethioate (11), and ethyl 3-amino-6-(naphthalen-2-yl)-4-(thiophen-2-yl)furo[2,3-b]pyridine-2-carboxylate (14) are among the most active inhibitors with IC50 values of 0.57, 0.24, 0.65, 0.50, and 0.93 µM, respectively, compared to roscovitine (IC50 0.394 μM). Most compounds showed significant inhibition on different human cancer cell lines (HCT-116, MCF-7, HepG2, and A549) with IC50 ranges of 31.3–49.0, 19.3–55.5, 22.7–44.8, and 36.8–70.7 μM, respectively compared to doxorubicin (IC50 40.0, 64.8, 24.7 and 58.1 µM, respectively). Furthermore, a molecular docking study suggests that most of the target compounds have a similar binding mode as a reference compound in the active site of the CDK2 enzyme. The structural requirements controlling the CDK2 inhibitory activity were determined through the generation of a statistically significant 2D-QSAR model.

scholarly journals Fucoidan, a major component of brown seaweed, prohibits the growth of human cancer cell lines in vitro

2008 ◽  
Author(s):  
Suguru Fukahori ◽  
Hirohisa Yano ◽  
Jun Akiba ◽  
Sachiko Ogasawara ◽  
Seiya Momosaki ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
Brown Seaweed ◽  
Cancer Cell Lines ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines
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