Serum Unbound Bilirubin Versus Transcutaneous Bilirubin in Jaundiced Term Neonates

2020 ◽  
Vol 5 (4) ◽  
pp. 1-4
Author(s):  
M.A. ELBISHRY ◽  
A.E. Elsadek ◽  
E.G. Behiry ◽  
M.A. Hasan
Keyword(s):  
Term Neonates ◽  
Transcutaneous Bilirubin ◽  
Unbound Bilirubin

Predictability of transcutaneous bilirubinometry in late preterm and term infants at risk for pathological hyperbilirubinemia

2020 ◽  
pp. 1-7
Author(s):  
E. Dianova ◽  
J. Fogel ◽  
R.P. Verma
Keyword(s):  
At Risk ◽  
Serum Bilirubin Level ◽  
Late Preterm ◽  
Term Infants ◽  
Term Neonates ◽  
Transcutaneous Bilirubin ◽  
Immune Mediated ◽  
Positive Direct ◽  
Neonatal Population ◽  
Transcutaneous Bilirubinometry

BACKGROUND: The aim was to assess the predictability of transcutaneous bilirubinometry in late preterm and term neonates at risk for pathological hyperbilirubinemia, and to identify the neonatal population in which transcutaneous bilirubin most accurately predicts serum bilirubin level (SB, mg/dl). METHODS: The correlations between transcutaneous bilirubin (TCB, mg/dl) and SB in different neonatal population subsets; and between ΔTSB (TCB-SB) and relevant neonatal variables and clinical groups were analyzed. RESULTS: TCB correlated with SB (r = 0.82, p <  0.05) in the cohort (n = 350) and in population subsets (r = 0.81–0.9, p <  0.001). Black infants with gestational age (GA) >35 weeks and chronological age (CA) >3 days recorded strongest correlation (r = 0.9, p <  0.001) followed by Blacks, and non-Black infants with CA >3 days and GA >35 weeks. ΔTSB was positive in Blacks, and in infants with CA <3 days, or with no phototherapy. ΔTSB was negative in non-Blacks, in infants with positive direct Coombs test (DC+) or those receiving phototherapy. Black race [beta (SE) = 1.3(0.33), p <  0.001] had positive, while CA [beta (SE) =−1.74 (0.36), p <  0.001], DC + status [beta (SE) =−0.72 (0.25), p = 0.004] and receipt of phototherapy [beta (SE) =−0.84 (0.21), p <  0.001] each had negative correlation with ΔTSB. ΔTSB for Blacks was >Whites, Hispanics and Asians. CONCLUSION: SB is best predicted by TCB in Black infants with CA over 3 days and GA over 35 weeks. Variability in SB estimation by TCB is race, CA and immune mediated hemolysis specific.

scholarly journals A 6-Day-Old Newborn with Vomiting and Jaundice

2021 ◽  
Vol 6 ◽  
pp. 5-8
Author(s):  
Nkechi Okotcha ◽  
Abbie Biggers ◽  
Jonathan Martin ◽  
Raphael Mattamal
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Serum Bilirubin ◽  
Severe Form ◽  
Intestinal Malrotation ◽  
Term Neonates ◽  
Transcutaneous Bilirubin ◽  
Bilirubin Encephalopathy

Sixty percent of term neonates and 80% of preterms have jaundice within the first week of life. Jaundice can be pathologic or physiologic, indirect, or direct. Indirect jaundice can be neurotoxic at high levels. In its most severe form, this presents as acute bilirubin encephalopathy or kernicterus. Screening for jaundice using a transcutaneous bilirubin check or serum bilirubin has contributed tremendously to the reduction of kernicterus, which ranges from 0.5-1.3/100,000 births. Often, the etiology is easy to decipher. Otherwise, it may be complicated when there are several factors contributing. We present a case of a 6-day-old with jaundice and vomiting who was suffering from intestinal malrotation and a urinary tract infection.

Breast-Feeding Frequency During the First 24 Hours After Birth in Full-Term Neonates

PEDIATRICS ◽  
1990 ◽  
Vol 86 (2) ◽  
pp. 171-175 ◽  
Author(s):  
Yoshitada Yamauchi ◽  
Itsuro Yamanouchi
Keyword(s):  
Weight Loss ◽  
Breast Feeding ◽  
Full Term ◽  
Feeding Frequency ◽  
Term Neonates ◽  
Transcutaneous Bilirubin ◽  
Factors Affecting ◽  
Beneficial Effects ◽  
Breast Fed ◽  
Maximum Weight Loss

The relation between the frequency of breast-feeding and intake, weight loss, meconium passage, and bilirubin levels was studied in 140 healthy, full-term, breast-fed, Japanese neonates born vaginally without complications. Factors affecting the frequency of breast-feeding were also evaluated. Mothers nursed their neonates, on average, 4.3 ± 2.5 (SD) times (range 0 to 11) during the first 24 hours after birth, and this frequency increased significantly to 7.4 ± 3.9 times during the next 24 hours (P &lt; .001). There was a significant correlation between the frequency of breast-feeding during the first and second 24 hours after birth (r = .69, P &lt; .001). The frequency of breast-feeding during the first 24 hours correlated significantly with frequency of meconium passage (r = .37, P &lt; .01), maximum weight loss (r = -.22, P &lt; .05), breast milk intake on day 3 (r = .50, P &lt; .01) and day 5 (r = .34, P &lt; .05), transcutaneous bilirubin readings on day 6 (r = -.18, P &lt; .05), and weight loss from birth to time of discharge (day 7) (r = -.32, P &lt; .01). There was a strong dose-response relationship between feeding frequency and a decreased incidence of significant hyperbilirubinemia (transcutaneous bilirubin readings ≥23.5) on day 6. The time of birth also affected the frequency of breast-feeding during the first 24 hours. Neonates born between midnight and 6:00 AM were nursed more frequently than those born between 1:00 PM and midnight (5.1 ± 2.4 vs 3.9 ± 2.3 times, P &lt; .05). The results demonstrate that frequent suckling in the first days of life has numerous beneficial effects on the breast-fed, full-term newborn.

Relationship between transcutaneous bilirubin and circulating unbound bilirubin in jaundiced neonates

2016 ◽  
Vol 103 ◽  
pp. 235-239 ◽  
Author(s):  
Emmanuelle Letamendia-Richard ◽  
Rafik Ben Ammar ◽  
Ascanio Tridente ◽  
Daniele De Luca
Keyword(s):  
Transcutaneous Bilirubin ◽  
Unbound Bilirubin

scholarly journals The Effect of Tactile-Kinesthetic Massage on Transcutaneous Bilirubin in Term Neonates With Hyperbilirubinemia Care With Phototherapy

2016 ◽  
Vol 11 (5) ◽  
pp. 13-19
Author(s):  
Alieh Jalalodini ◽  
Manijeh Nourian ◽  
Laleh Goodarzvand ◽  
Mojgan Jahantigh ◽  
Mahdi Rezvani Amin ◽  
...  
Keyword(s):  
Term Neonates ◽  
Transcutaneous Bilirubin

scholarly journals The prevalence of neonatal jaundice and risk factors in healthy term neonates at National District Hospital in Bloemfontein

2018 ◽  
Vol 10 (1) ◽  
Author(s):  
Hanneke Brits ◽  
Jeanie Adendorff ◽  
Dyanti Huisamen ◽  
Dahne Beukes ◽  
Kristian Botha ◽  
...  
Keyword(s):  
Risk Factors ◽  
Neonatal Jaundice ◽  
District Hospital ◽  
High Serum ◽  
Normal Vaginal Delivery ◽  
Cross Sectional ◽  
Term Neonates ◽  
Transcutaneous Bilirubin ◽  
Clinical Appearance ◽  
Non Invasive

Background: Neonatal jaundice affects one in two infants globally. The jaundice is the result of an accumulation of bilirubin as foetal haemoglobin is metabolised by the immature liver. High serum levels of bilirubin result in lethargy, poor feeding and kernicterus of the infant.Aim: The main aim of this article was to determine the prevalence of neonatal jaundice and secondly to explore its risk factors in healthy term neonates.Setting: Maternity ward, National District Hospital, Bloemfontein, South Africa.Methods: In this cross-sectional study, mothers and infants were conveniently sampled after delivery and before discharge. The mothers were interviewed and their case records were reviewed for risk factors for neonatal jaundice and the clinical appearance and bilirubin levels of the infants were measured with a non-invasive transcutaneous bilirubin meter.Results: A total of 96 mother-infant pairs were included in the study. The prevalence of neonatal jaundice was 55.2%; however, only 10% of black babies who were diagnosed with jaundice appeared clinically jaundiced. Normal vaginal delivery was the only risk factor associated with neonatal jaundice. Black race and maternal smoking were not protective against neonatal jaundice as in some other studies.Conclusion: More than half (55.2%) of healthy term neonates developed neonatal jaundice. As it is difficult to clinically diagnose neonatal jaundice in darker pigmented babies, it is recommended that the bilirubin level of all babies should be checked with a non-invasive bilirubin meter before discharge from hospital or maternity unit as well as during the first clinic visit on day 3 after birth.

Accuracy of transcutaneous bilirubin measured by the BiliCare device in late preterm and term neonates

2016 ◽  
Vol 29 (22) ◽  
pp. 3641-3645 ◽  
Author(s):  
Ratchada Kitsommart ◽  
Buranee Yangthara ◽  
Punnanee Wutthigate ◽  
Bosco Paes
Keyword(s):  
Late Preterm ◽  
Term Neonates ◽  
Transcutaneous Bilirubin

scholarly journals Relationship of Transcutaneous Billirubin with Serum Billirubin in Neonates with Jaundice

2017 ◽  
Vol 4 (3) ◽  
pp. 1037
Author(s):  
Vivek Arora ◽  
Sanjay Singla ◽  
Poornima Sharma ◽  
Rameshwar Ninama ◽  
Harimohan Koli
Keyword(s):  
Mean Difference ◽  
Total Serum ◽  
P Value ◽  
Term Neonates ◽  
Transcutaneous Bilirubin ◽  
Significant Difference ◽  
Allowable Error ◽  
Preterm Babies ◽  
Time Of Admission ◽  
Relationship Of

Background: Neonatal hyperbilirubinemia is a common problem in neonates with an incidence of about 60% in term babies and 80% in preterm babies. It is the commonest cause of admission to the hospitals in the newborn period. Studies comparing the correlation between total serum bilirubin (SBR) and transcutaneous bilirubin (TcB) have yielded different results. So, we planned this study to find out relationship between TcB and SBR values.Methods: A hospital based prospective study was done during March 2016 to September 2016, in which a total of 120 newborns including term and preterm who were admitted with neonatal jaundice in NICU, Maharana Bhupal Hospital, Udaipur, Rajasthan were assessed in terms of age, sex and weight and investigated for both TcB and SBR. The sample size was calculated at a confidence interval of 90% and allowable error of 15%.Results: Out of total 120 study subjects, 59 (49%) were males and 61 (51%) were females, out of which 53 (44%) were preterm and 67 (56%) were term neonates. Mean TcB and SBR values at the time of admission has a mean difference of 2.52 mg/dl with a p-value <0.001 (significant) on the other hand TcB and SBR at 24 hr of admission has a mean difference of 1.57 with a p-value >0.001, which is non-significant. TcB and SBR at 48 and 72 hr of admission also has a mean difference which is also non- significant (p >0.001).Conclusions: From present study, we conclude that there is no significant difference between TcB and SBR values at 24, 48 and 72 hrs after starting phototherapy. The values of TcB are equally reliable as SBR values. 

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