Ocular delivery of flurbiprofen from ophthalmic liposomes dispersed in thermosensitive gel

2000 ◽  
Vol 23 (2) ◽  
pp. 165-175
Author(s):  
A. Abd-Elmageed ◽  
F. Yamashita ◽  
M. Hashida
Keyword(s):  
Ocular Delivery ◽  
Thermosensitive Gel

Characterization of a new ocular delivery system based on a dispersion of liposomes in a thermosensitive gel

1998 ◽  
Vol 162 (1-2) ◽  
pp. 119-127 ◽  
Author(s):  
Amélie Bochot ◽  
Elias Fattal ◽  
Jean Louis Grossiord ◽  
Francis Puisieux ◽  
Patrick Couvreur
Keyword(s):  
Delivery System ◽  
Ocular Delivery ◽  
Thermosensitive Gel ◽  
Ocular Delivery System

Novel PH-Thermosensitive Gel Adsorbents for Phosphoric Acid

2008 ◽  
Author(s):  
Takehiko Gotoh ◽  
Takuya Arase ◽  
S. Sakohara
Keyword(s):  
Phosphoric Acid ◽  
Thermosensitive Gel

Moxifloxacin Hydrochloride-Loaded Eudragit® RL 100 and Kollidon® SR Based Nanoparticles: Formulation, In vitro Characterization and Cytotoxicity.

2020 ◽  
Vol 23 ◽  
Author(s):  
Gülsel Yurtdaş Kırımlıoğlu ◽  
Sinan Özer ◽  
Gülay Büyükköroğlu ◽  
Yasemin Yazan
Keyword(s):  
Particle Size ◽  
Zeta Potential ◽  
Spray Drying ◽  
Prolonged Release ◽  
Ocular Delivery ◽  
Corneal Permeability ◽  
Release Pattern ◽  
In Vitro Characterization ◽  
Ocular Bioavailability

Background: Considering the low ocular bioavailability of conventional formulations used for ocular bacterial infection treatment, there’s a need for designing efficient novel drug delivery systems that may enhance of precorneal retention time and corneal permeability. Aim and Objective: The current research focuses on developing nanosized and non-toxic Eudragit® RL 100 and Kollidon® SR nanoparticles loaded with moxifloxacin hydrochloride (MOX) for its prolonged release to be promising for effective ocular delivery. Methods: In this study, MOX was incorporation was carried out by spray drying method aiming ocular delivery. In vitro characteristics were evaluated in detail with different methods. Results: MOX was successfully incorporated into Eudragit® RL 100 and Kollidon® SR polymeric nanoparticles by spray-drying process. Particle size, zeta potential, entrapment efficiency, particle morphology, thermal, FTIR, XRD and NMR analyses and MOX quantification using HPLC method were carried out to evaluate the nanoparticles prepared. MOX loaded nanoparticles demonstrated nanosized and spherical shape while in vitro release studies demonstrated modified release pattern which followed Korsmeyer-Peppas kinetic model. Following successful incorporation of MOX into the nanoparticles, the formulation (MOX: Eudragit® RL 100, 1:5) (ERL-MOX 2) was selected for further studies by the reason of its better characteristics like cationic zeta potential, smaller particle size, narrow size distribution and more uniform prolonged release pattern. Moreover, ERL-MOX 2 formulation remained stable for 3 months and demonstrated higher cell viability values for MOX. Conclusion: In vitro characterization analyses showed that non-toxic, nano-sized and cationic ERLMOX 2 formulation has the potential of enhancing ocular bioavailability.

Quercetin delivery to porcine cornea and sclera by solid lipid nanoparticles and nanoemulsion

RSC Advances ◽  
2015 ◽  
Vol 5 (122) ◽  
pp. 100923-100933 ◽  
Author(s):  
Chi-Hsien Liu ◽  
Yun-Chun Huang ◽  
Jhe-Wei Jhang ◽  
Yu-Hong Liu ◽  
Wei-Chi Wu
Keyword(s):  
Solid Lipid Nanoparticles ◽  
Lipid Nanoparticles ◽  
Ocular Delivery ◽  
Solid Lipid ◽  
Porcine Cornea

Two potential nanocarriers including nanoemulsions and solid lipid nanoparticles have been demonstrated as vehicles for quercetin encapsulation and ocular delivery.

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