scholarly journals PROTECTIVE EFFECT OF FOLIC ACID AGAINST H2O2 INDUCED-HEPATIC OXIDATIVE STRESS IN AGED RATS

2007 ◽  
Vol 15 (2) ◽  
pp. 383-394
Author(s):  
Dalia El-Nahal ◽  
Abeer El-Dakak ◽  
Mona Ahmed
Keyword(s):  
Oxidative Stress ◽  
Folic Acid ◽  
Protective Effect ◽  
Aged Rats ◽  
Hepatic Oxidative Stress

scholarly journals PROTECTIVE EFFECT OF FOLIC ACID ON OXIDATIVE STRESS INDUCED BY METHIONINE OVERLOAD IN MALE MICE

2021 ◽  
Vol 21 (Suppliment-1) ◽  
pp. 1430-1434
Author(s):  
Tuqa Sabbar Rahi ◽  
Wifaq j. albazi ◽  
Ali K. Aljarah ◽  
Alaa Hussein AL-Safy
Keyword(s):  
Oxidative Stress ◽  
Folic Acid ◽  
Protective Effect ◽  
Male Mice

scholarly journals Protective effect of caffeine and a selective A2A receptor antagonist on impairment of memory and oxidative stress of aged rats

2011 ◽  
Vol 46 (4) ◽  
pp. 309-315 ◽  
Author(s):  
Marlon Régis Leite ◽  
Ethel A. Wilhelm ◽  
Cristiano R. Jesse ◽  
Ricardo Brandão ◽  
Cristina Wayne Nogueira
Keyword(s):  
Oxidative Stress ◽  
Protective Effect ◽  
Receptor Antagonist ◽  
Aged Rats ◽  
A2a Receptor ◽  
And Oxidative Stress

The Protective Effect of Cilostazol in Genotoxicity Induced by Methotrexate in Human Cultured Lymphocytes

2020 ◽  
Vol 13 (2) ◽  
pp. 137-143
Author(s):  
Abeer M. Rababa’h ◽  
Samah A. Hussein ◽  
Omar F. Khabour ◽  
Karem H. Alzoubi
Keyword(s):  
Oxidative Stress ◽  
Folic Acid ◽  
Protective Effect ◽  
Mitotic Index ◽  
Chromosomal Damage ◽  
Proliferative Index ◽  
Proliferative Effect ◽  
Phosphodiesterase Iii Inhibitor ◽  
Phosphodiesterase Iii ◽  
Healthy Body

Background: Methotrexate is an antagonist of folic acid that has been shown to be genotoxic to healthy body cells via induction of oxidative stress. Cilostazol is a phosphodiesterase III inhibitor and a potent antioxidant drug. Objectives: To evaluate the potential protective effect of cilostazol on methotrexate genotoxicity. Results: Methotrexate significantly increased the frequency of CAs and SCEs (p < 0.0001) as compared to control cultures. This chromosomal damage induced by methotrexate was considerably decreased by pretreatment of the cells with cilostazol (P < 0.01). Moreover, the results showed that methotrexate resulted in a notable reduction (P < 0.01) in cells kinetic parameters, the mitotic index (MI) and the proliferative index (PI). Similarly, cilostazol significantly reduced the mitotic index, which could be related to the anti-proliferative effect (P < 0.01). Conclusion: Methotrexate is genotoxic, and cilostazol could prevent the methotrexate-induced chromosomal damage with no modulation of methotrexate-induced cytotoxicity.

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