PROTECTIVE AND THERAPEUTIC EFFECTS OF OLIVE OIL AND FICUS CARICA AS NATURAL ANTIOXIDANTS ON SOME BIOCHEMICAL PARAMETERS IN LIVER OF γ-IRRADIATED MALE ALBINO RATS

2014 ◽  
Vol 25 (1) ◽  
pp. 1-16 ◽  
Author(s):  
Mohamed Bashandy ◽  
Hesham Abd El- Rasheid ◽  
Hesham Hasan ◽  
Abdallah Fathya
Keyword(s):  
Olive Oil ◽  
Biochemical Parameters ◽  
Natural Antioxidants ◽  
Ficus Carica ◽  
Albino Rats ◽  
Therapeutic Effects

scholarly journals Therapeutic Effects of Viscum album Combined with Garcinia kola against CCL4 Induced Liver Injury in Albino Rats

2019 ◽  
pp. 1-8
Author(s):  
Roseline Emeji ◽  
Tamuno-Emine Davies Gabriel ◽  
Bosia Ndokiari
Keyword(s):  
Body Weight ◽  
Liver Injury ◽  
Biochemical Parameters ◽  
Viscum Album ◽  
Albino Rats ◽  
Histological Structure ◽  
Therapeutic Effects ◽  
Herbal Extracts ◽  
Garcinia Kola ◽  
Group 1

This study was aimed at evaluating the efficacy of Viscum album (mistletoe) and Garcinia kola seed (bitter kola) in treating Rat liver against CCl4-induced liver injury. Mistletoe and bitter Kola are used in traditional medicine for the treatment of various disorders, including hepatic disorders. Biochemical parameters and histological structure were assessed and used as a measure of the therapeutic potential of the herbs against CCl4 induced liver injury. The experimental animals (15 male wistar albino rats) weighing between 100-120 g were randomly divided into three (3) groups. Each group comprised 5 rats and was labeled as group 1, 2 or 3. Group 1 (negative control) animals were administered saline orally daily for 6 weeks (1 ml volume per kg body weight) while group 2 (CCl4 group) animals were administered CCl4 mixed with olive oil as vehicle in 1:1 ratio (3 ml/kg body weight). Group 3 represented the treatment group with extracts of the two herbal plants (250 mg/kg daily). The combination of the herbal extracts administered orally for 6weeks showed a significant decrease (P<0.05) in serum protein, albumin, total bilirubin and conjugated bilirubin concentrations and in serum activities of AST, ALT, ALP and GGT compared with CCl4-induced increases in concentrations or activities of the aforementioned biochemical parameters. Histological examination of the liver of CCl4–treated rats with the combined herbal extracts showed less destruction of liver architecture in comparison to the group induced with CCl4 only. The results indicated that the combination herbal extracts investigated (mistletoe and bitter kola) had therapeutic effect against CCL4-induced liver injury when used either in combination and this effect could be due to the phytochemicals present in the herbs.

Studies on oxidative stabilisation of lard by natural antioxidants recovered from olive-oil mill wastewater

2007 ◽  
Vol 100 (3) ◽  
pp. 998-1004 ◽  
Author(s):  
Antonella De Leonardis ◽  
Vincenzo Macciola ◽  
Giuseppe Lembo ◽  
Alessandra Aretini ◽  
Ahindra Nag
Keyword(s):  
Olive Oil ◽  
Natural Antioxidants ◽  
Olive Oil Mill Wastewater

Effect of leaf extracts of Carica papaya (Paw paw) and Pakia biglobosa (African locust bean) on some biochemical parameters of albino rats

2021 ◽  
Vol 1 (2) ◽  
pp. 014-021
Author(s):  
Michael Okey Enemali ◽  
Kingsley Ikechukwu Ubaoji ◽  
Chinenye Enoch Oguazu ◽  
Gambo Sunday Haruna ◽  
Kingsley Kelechi Asogwa
Keyword(s):  
Biochemical Parameters ◽  
Carica Papaya ◽  
Control Group ◽  
Albino Rats ◽  
Serum Concentrations ◽  
Leaf Extracts ◽  
Orthodox Medicine ◽  
Laboratory Methods ◽  
African Locust Bean ◽  
Made In

In spite of the advances made in orthodox medicine, there has been an increasing interest in herbal medicine. The leaves of Carica papaya and Pakia biglobosa have been reported to contain lots of beneficial medicinal compounds, hence their use in the traditional prevention, management and treatment of ailments/diseases. In this study, the effect of varied concentrations of the ethanol leaf extract of the plants on some biochemical parameters of albino rats was assessed. The phytochemical compositions of the leaves were determined using established standard laboratory methods. Fifty four male Albino rats weighing between 150g-200g were randomly distributed into nine groups of six animals each. A daily single dose of 500mg/kg, 1000mg/kg, 1500mg/kg and 2000mg/kg body weight of either of the extracts was respectively, administered to the eight test groups for fourteen days. The control group was given only feed and water. Biochemical parameters such as the serum activities of Aspartate Aminotransferase, Alanine Aminotranferase and Alkaline phosphatase as well as the serum concentrations of Bilirubin, Albumin, HCO3-, Urea, Creatinine and Na+ were assessed. Result of the analyses showed that the administration of the extracts did not significantly raise the serum activity of ALT. The decreases in serum concentrations of Urea and increase in the concentration of HCO3- were directly proportional to the concentration of the extracts. It can be deduced from this study, that 500mg, 1000mg 1500mg and 2000mg/kg bw of either C. papaya or P. biglobosa did not elicit any marked hepatotoxicological or renotoxicological effect on the experimental animals

scholarly journals Deterioration of Extra Virgin Olive Oil Caused by Different Processes

2017 ◽  
Vol 6 (5) ◽  
pp. 59 ◽  
Author(s):  
Nadia Segura ◽  
Yenny Pinchak ◽  
Natalie Merlinski ◽  
Miguel Amarillo ◽  
Camila Feller ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Oxidative Stability ◽  
Antioxidant Capacity ◽  
Olive Oil ◽  
Virgin Olive Oil ◽  
Natural Antioxidants ◽  
Extra Virgin Olive Oil ◽  
Total Phenols ◽  
Olive Oils ◽  
Useful Life

Extra virgin olive oil is recognized as a very stable oil because of its composition in fatty acids and its content in natural antioxidants (tocopherols and polyphenols). In the bibliography are works that address different aspects of this stability, from the duration of its useful life to its performance in the frying of foods. Some works also link their stability with the content of natural antioxidants. For example, Franco et al. (2014) studied the content of phenols and their antioxidant capacity in olive oils of seven different varieties. Baccouri et al. (2008) found a good correlation between the oxidative stability (measured in Rancimat) of the oils studied and the concentration of total phenols and tocopherols.

scholarly journals Effect of aspartame on biochemical and oxidative stress parameters in rat blood

2015 ◽  
Vol 67 (2) ◽  
pp. 535-545 ◽  
Author(s):  
Marko Prokic ◽  
Milica Paunovic ◽  
Milos Matic ◽  
Natasa Djordjevic ◽  
Branka Ognjanovic ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Biochemical Parameters ◽  
White Blood Cells ◽  
Lipid Peroxides ◽  
Hdl Cholesterol ◽  
Albino Rats ◽  
Total Body Mass ◽  
Antioxidative Status

Aspartame (ASP) is one of the most widely used nonnutritive sweeteners. This study investigates the chronic effects of ASP on hematological and biochemical parameters, and its effects on the oxidative/antioxidative status in the red blood cells of Wistar albino rats. Rats were provided with ASP (40 mg/kg/daily for six weeks) in drinking water. Increased food and fluid intake was observed in the ASP-treated rats. Total body mass was significantly decreased in the ASP-treated rats. Treatment with ASP caused an increase in the concentrations of glucose, cholesterol, LDL-cholesterol, and in the activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and lactate dehydrogenase (LDH), as well as a decrease in the levels of HDL-cholesterol in the serum. A significant decline in the number of white blood cells (WBC) was observed after ASP uptake. Based on the results we conclude that ASP induces oxidative stress, observed as an alteration of the glutathione redox status, which leads to increased concentrations of nitric oxide (NO) and lipid peroxides (LPO) in the red blood cells. Changes in biochemical parameters, lipid metabolism, as well as changes in the levels of oxidative stress markers and the appearance of signs of liver damage indicate that chronic use of ASP can lead to the development of hyperglycemia, hypercholesterolemia and associated diseases.

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