scholarly journals PROTECTIVE ROLE OF MELATONIN ON SOME BIOCHEMICAL ASPECTS OF NICOTINE ADMINISTRATION ON BRAIN OVARIECTOMIZED FEMALE RATS

2008 ◽  
Vol 19 (Issue 1-C) ◽  
pp. 1-13
Author(s):  
AMIRA MERSAL
Keyword(s):  
Protective Role ◽  
Female Rats ◽  
Nicotine Administration

scholarly journals The Effect of a Mediterranean Meal on Sprague Dawley Rats DMBA-Induced Mammary Tumors

2010 ◽  
Vol 3 ◽  
pp. CGM.S5894
Author(s):  
Paula C. Pereira ◽  
A. Filipa Vicente ◽  
Maria F. Mesquita ◽  
Antonio S. Cabrita
Keyword(s):  
Experimental Studies ◽  
Protective Role ◽  
Female Rats ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Total Cancer ◽  
Group A ◽  
Histopathologic Analysis ◽  
Group B

The present study intents to find a possible protective role of a Mediterranean type meal on mammary carcinogenesis. Several factors have been associated with breast cancer risk, genetics and environment are the most pointed out in epidemiologic and experimental studies. Diet is an environmental factor that can promote or prevent disease, being responsible for almost 35% of total cancer cases. A total of 72 female rats 50 days old were randomly divided in three groups of 24 rats and housed 4 in each plastic cage in a holding room under constant conditions of 22 ± 2 °C, 55 ± 10% humidity and a 12 h light/dark cycle. All the animals were submitted to the administration of 20 mg of 7, 12 dimethylbenzanthracene (DMBA) in olive oil, by gavages, except group A. The same defined standard food was provided for all the animals in group A and B, supplemented with a Mediterranean meal in group C. All the animals were sacrificed by the end of 150 days. Total carcinoma number did not differ significantly between Groups B and C and there were not found any neoplastic lesions in Group A. Most tumors showed a mixed architectural pattern, with cribriform and papillary areas, comedocarcinoma and necrosis was only seen in Group B. Histopathologic analysis showed that Group C tumors had lower mitotic activity and Pattern Grades, but higher Nuclear Grades. Mediterranean diet type meal showed lower Pattern Grades and lower Mitotic count in spite of that a higher nuclear pleomorphism was also found. Even so, tumors from Group C were better differentiated which can indicate lower malignancy.

Protective role of tannin-rich fraction of Camellia sinensis in tissue arsenic burden in Sprague Dawley rats

2010 ◽  
Vol 29 (9) ◽  
pp. 705-719 ◽  
Author(s):  
C. Chandronitha ◽  
S. Ananthi ◽  
G. Ramakrishnan ◽  
R. Lakshmisundaram ◽  
V. Gayathri ◽  
...  
Keyword(s):  
Green Tea ◽  
Camellia Sinensis ◽  
Sodium Arsenite ◽  
Defense Mechanism ◽  
Aminolevulinic Acid ◽  
Protective Role ◽  
Female Rats ◽  
Tbars Level ◽  
Sprague Dawley

The protective effect of green tea (Camellia sinensis) was tested against arsenic-induced toxicity. However, the possible role of tannins in green tea in alleviating hepatic and renal oxidative injury has also been studied. Administration of sodium arsenite (100 mg/kg/day) for 28 days in Sprague Dawley female rats resulted in significant reduction of biochemical parameters such as delta-aminolevulinic acid dehydratase (ALAD), reduced glutathione (GSH), glutathione peroxidase (GPx), superoxide dismutase (SOD) and elevation of thiobarbituric acid reactive substances (TBARS) and the index of nitrite/nitrate (NOx) levels. The tissue arsenic burden was increased after arsenic exposure for a period of 28 days. Green tea crude fraction (GTC) co-treated with sodium arsenite for 28 days caused significant (p < .01) elevation of ALAD, GSH, GPx, SOD, and nitrate/nitrite levels and reduction of the TBARS level and tissue burden when compared to detannified green tea fraction (GTDT)-treated groups. The protective role of tannin-rich fraction of C. sinensis when compared to the detannified fraction was also confirmed by histological examinations. The greater activity of GTC than that of detannified green tea fraction correlates with the higher content of tannins in green tea. Overall, these results indicate that the tannin-rich green tea could have improved the defense mechanism against arsenic-induced oxidative stress and reduced the tissue arsenic burden.

scholarly journals Dextrose Hydration May Promote Cisplatin-induced Nephrotoxicity in Rats: Gender-related Difference

2019 ◽  
Vol 11 (2) ◽  
pp. 136-44
Author(s):  
Farzaneh Karimi ◽  
Sayyedehnikta Kasaei ◽  
Azar Baradaran ◽  
Farzaneh Ashrafi ◽  
Ardeshir Talebi ◽  
...  
Keyword(s):  
Kidney Tissue ◽  
Serum Levels ◽  
Protective Role ◽  
Female Rats ◽  
Male And Female ◽  
Cisplatin Nephrotoxicity ◽  
Male And Female Rats ◽  
Before And After ◽  
Different Doses

BACKGROUNDS: Cisplatin (CP) as an anticancer drug may affect the plasma glucose level while diabetic subjects are protected against CP-induced nephrotoxicity. In the current study, the role of dextrose hydration during CP therapy on CP-induced nephrotoxicity was evaluated.METHODS: Sixty-nine male and female rats were divided into 12 groups. The rats were hydrated with 15 mL/kg vehicle or different doses of 2%, 10% and 20% dextrose before and after 7.5 mg/kg CP administration. One week later, the biochemical and kidney function markers, and histology finding were determined.RESULTS: All the animals co-treated with CP and 20% dextrose, were dead during one week of the experiment. Administration of CP alone increased kidney tissue damage score (KTDS) and kidney weight (KW). It also elevated the blood urea nitrogen (BUN) and BUN-creatineine ratio (BUN/Cr) levels in the serum. In addition, CP decreased body weight and creatinine (Cr) clearance (ClCr) significantly in both male and female rats (p<0.05). However, 2% and 10% dextrose did not alter the mentioned parameters in male, but 10% dextrose supplement increased the serum levels of BUN, Cr and BUN/Cr ratio, KW and KTDS significantly in female rats (p<0.05).CONCLUSION: Our data suggest that not only do not support the nephro-protective role of dextrose hydration during CP therapy, the dextrose hydration can act as risk factor to promote CP-induced nephrotoxicity in female rats. Prohibition of high carbohydrate (glucose) diet during CP therapy is recommended.KEYWORDS: cisplatin, nephrotoxicity, dextrose, rat, gender

scholarly journals Protective role of 17β-estradiol treatment in renal injury on female rats submitted to brain death

2021 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Roberto Armstrong-Jr ◽  
Fernanda Yamamoto Ricardo-da-Silva ◽  
Marina Vidal-dos-Santos ◽  
Cristiano de Jesus Correia ◽  
Lucas Ferreira Anunciação ◽  
...  
Keyword(s):  
Brain Death ◽  
Renal Injury ◽  
Protective Role ◽  
Female Rats ◽  
Estradiol Treatment ◽  
17Β Estradiol
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