scholarly journals case of porencephaly complicated by central diabetes insipidus in a dog

2021 ◽  
Vol 77 (01) ◽  
pp. 6489-2021
Author(s):  
ALI EVREN HAYDARDEDEOĞLU ◽  
EKREM ÇAĞATAY ÇOLAKOĞLU ◽  
HADI ALIHOSSEINI
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Veterinary Medicine ◽  
Diabetes Insipidus ◽  
Central Diabetes Insipidus ◽  
Mri Features ◽  
Rare Congenital Disorder ◽  
The Central Nervous System ◽  
Cerebral Cysts ◽  
Intranasal Desmopressin

Porencephaly is an extremely rare congenital disorder of the central nervous system characterized by focal cerebral cysts and cavities. Central diabetes insipidus is also a well-described condition in veterinary medicine. A 4-year-old Terrier dog was referred to the hospital with polyuria and polydipsia. Based on a diagnostic examination, porencephaly complicated by central diabetes insipidus was determined. Treatment consisted in administering intranasal desmopressin to the conjunctiva. The dog remains clinically healthy for 2 years. This case report reflects the MRI features of porencephaly and central diabetes insipidus associated with congenital porencephaly.

Increased hexokinase activity in forebrain of water-deprived and diabetes insipidus rats

1986 ◽  
Vol 251 (2) ◽  
pp. R268-R273
Author(s):  
T. L. Krukoff ◽  
W. E. Turton ◽  
F. R. Calaresu
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Diabetes Insipidus ◽  
Metabolic Activity ◽  
Body Fluid ◽  
Supraoptic Nucleus ◽  
Preoptic Area ◽  
Fluid Regulation ◽  
The Central Nervous System ◽  
Body Fluid Regulation

Metabolic studies using the 2-[14C]deoxy-D-glucose and cytochrome oxidase techniques have demonstrated changes in the activity of central sites associated with the hypothalamoneurohypophysial system in water-deprived (WD) and diabetes insipidus (DI) rats. Another method that may be used as an index of metabolic activity in discrete regions of the central nervous system is the measurement of hexokinase (HK) activity. This study describes changes in metabolic activity, as measured by HK histochemistry, in regions of the forebrain of WD and DI rats. Significant increases in HK activity measured by densitometric analysis were observed in the magnocellular component of the paraventricular nucleus of the hypothalamus, supraoptic nucleus, nucleus circularis, and neurohypophysis of WD and DI rats. In addition, increased HK activity was observed in the preoptic area and subfornical organ of DI rats. These data demonstrate that metabolic changes occur in the forebrain of WD and DI rats within structures involved in body fluid regulation. The present study also demonstrates that HK histochemistry may be used as a marker of metabolic activity in discrete regions of the central nervous system.

Primary angiitis of the central nervous system: MRI features and clinical presentation

2003 ◽  
Vol 47 (2) ◽  
pp. 127-134 ◽  
Author(s):  
Surendra Singh ◽  
Susan John ◽  
Thykkoothathil Pappy Joseph ◽  
Thilak Soloman
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Clinical Presentation ◽  
Mri Features ◽  
Primary Angiitis ◽  
The Central Nervous System

MRI features of canine hemangiosarcoma affecting the central nervous system

2021 ◽  
Author(s):  
Claudia Mallol ◽  
Rodrigo Gutierrez‐Quintana ◽  
Gawain Hammond ◽  
Daniela Schweizer‐Gorgas ◽  
Steven De Decker ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Mri Features ◽  
The Central Nervous System

scholarly journals Neurosarcoidosis Presentation as Adipsic Diabetes Insipidus Secondary to a Pituitary Stalk Lesion and Association with Anti-NMDA Receptor Antibodies

2020 ◽  
Vol 2020 ◽  
pp. 1-5 ◽  
Author(s):  
Jose Gabriel Solis ◽  
Arturo Olascoaga Lugo ◽  
Marco Antonio Rodríguez Florido ◽  
Bayron Alexander Sandoval Bonilla ◽  
Jose Malagón Rangel
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Nmda Receptor ◽  
Diabetes Insipidus ◽  
Skin Lesions ◽  
Pituitary Mass ◽  
Atypical Symptoms ◽  
The Central Nervous System ◽  
Noncaseating Granulomas ◽  
Receptor Antibodies

Sarcoidosis is a multisystemic inflammatory disease of unknown cause. It is characterized by the presence of noncaseating granuloma on a biopsy specimen. Clinical presentation varies across case report series with myriad of symptoms ranging from fever, respiratory symptoms, and skin lesions, or atypical symptoms like heart block or neurological symptoms. Hence, we report the case of a 22-year-old woman with encephalitis, a pituitary mass, and adipsic diabetes insipidus. The diagnostic approach did not end on the biopsy of the lesion, which reported noncaseating granulomas; on the contrary, it was the beginning of a path to exclude other causes of the central nervous system granulomas that ended with the diagnosis of the isolated central nervous system sarcoidosis. Also, we report the first proven association between anti-NMDA receptor antibodies and sarcoidosis.

scholarly journals Hypopituitarism and Central Diabetes Insipidus Caused by Central Nervous System Lymphoma

2018 ◽  
Vol 57 (22) ◽  
pp. 3335-3336 ◽  
Author(s):  
Yasuo Zenimaru ◽  
Mika Yamada ◽  
Jinya Suzuki ◽  
Tadashi Konoshita
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Diabetes Insipidus ◽  
Central Nervous System Lymphoma ◽  
Central Diabetes Insipidus

scholarly journals Diabetes insipidus and hypopituitarism in HIV: an unexpected cause

2017 ◽  
Vol 2017 ◽  
Author(s):  
Carlos Tavares Bello ◽  
Francisco Sousa Santos ◽  
João Sequeira Duarte ◽  
Carlos Vasconcelos
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Diabetes Insipidus ◽  
Clinical Entity ◽  
Central Diabetes Insipidus ◽  
Positive Patient ◽  
Hiv Positive ◽  
Cns Lymphoma ◽  
List Type ◽  
Cns Lymphomas

Summary Central diabetes insipidus (DI) is a rare clinical entity characterized by low circulating levels of antidiuretic hormone (ADH) presenting with polyuria and volume depletion. Pituitary surgery is the most common cause of central DI in adults. Pituitary and hypothalamic disease, particularly invasive neoplasms, rarely cause DI, being idiopathic cases responsible for the majority of non-surgical cases. HIV patients, especially those with poor virulogical control, are prone to the development of CNS neoplasms, particularly lymphomas. These neoplasms usually become manifest with mass effects and seizures. Central DI and hypopituitarism are uncommon initial manifestations of primary CNS lymphomas. The authors describe the case of 29-year-old female, HIV-positive patient whose CNS lymphoma presented with DI. Learning points: Central diabetes insipidus has multiple causes and central nervous system lymphomas are not often considered in the differential diagnosis due to their low prevalence. Accurate biochemical diagnosis should always be followed by etiological investigation. The HIV population is at risk for many neoplasms, especially CNS lymphomas. New-onset polyuria in an HIV-positive patient in the absence of focal neurological signs should raise the suspicion for a central nervous system process of neoplastic nature. This clinical entity usually constitutes a therapeutical challenge, often requiring a multidisciplinary approach for optimal outcome.

scholarly journals Central Diabetes Insipidus in a Cat with Central Nervous System B Cell Lymphoma

2011 ◽  
Vol 13 (10) ◽  
pp. 787-792 ◽  
Author(s):  
Christopher J Simpson ◽  
Caroline S Mansfield ◽  
Marjorie E Milne ◽  
Priscilla J Hodge
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Diabetes Insipidus ◽  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Central Diabetes Insipidus

scholarly journals Multifocal Multisystem Langerhans Cell Histiocytosis in an Adult Female Atypically Presenting With Multiple Abdominopelvic Abscesses

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A1040-A1041
Author(s):  
Brian Khong ◽  
Maximiliano Hyon
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Soft Tissue ◽  
Diabetes Insipidus ◽  
Adult Female ◽  
Langerhans Cell Histiocytosis ◽  
Unusual Case ◽  
Langerhans Cell ◽  
Central Diabetes Insipidus ◽  
History Of

Abstract Introduction: Langerhans Cell Histiocytosis (LCH) is a condition of malignant clonal proliferation of myeloid bone marrow cells that more commonly affects children than adults. Furthermore, its presentation remains variable ranging from single organ to multisystem involvement including bone, skin, lymph, liver, spleen, lung, and central nervous system. We report an unusual case of multisystem LCH in an adult female presenting with multiple soft tissue abscesses. Case: We report a case of a 38-year-old female with a past medical history of polysubstance abuse, type 2 diabetes, polycystic ovarian syndrome, and isolated central diabetes insipidus who had multiple hospitalizations for recurrent soft tissue abscesses treated with incision and drainage and antibiotics. Imaging studies revealed multiple osteolytic lesions involving the bilateral iliac crests, acetabulum and femur, as well as an iliopsoas abscess. Given her prior history of isolated central diabetes insipidus, the possibility of LCH as the cause was entertained. Histological evaluation performed on an inguinal soft tissue sample stained positive for CD1a and S100, and a formal diagnosis of Langerhans Cell Histiocytosis (LCH) was made. The patient was treated with chemotherapy with good results. Conclusion: This report presents a rare and unusual case of adult onset multisystem LCH involving bone, skin, lymph, and central nervous system presenting with recurrent large abdominopelvic abscesses. These abscesses may represent a rare and unrecognized form of soft tissue involvement of LCH.

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