scholarly journals Skin transplantation in mice as an animal model for functional analysis of T regulatory cells.

2018 ◽  
Vol 74 (1) ◽  
pp. 6034-2018
Author(s):  
ANNA ŻYŁKO ◽  
ANNA WARDOWSKA ◽  
PIOTR TRZONKOWSKI
Keyword(s):  
Multiple Sclerosis ◽  
Allograft Rejection ◽  
T Regulatory Cells ◽  
Tolerance Induction ◽  
Skin Grafting ◽  
Immunological Tolerance ◽  
Skin Transplantation ◽  
Regulatory Cells ◽  
Immune Tolerance Induction

The role of T regulatory cells (Tregs) in transplantology has been widely studied over the years. The mouse model of skin transplantation is used as a quick and easy way to monitor the immune response of Tregs, vital for creation and maintenance of homeostasis and immunological tolerance. This model is extremely useful in the assessment of allograft rejection and immune tolerance induction dependent on Tregs. The procedure of skin transplantation is widely used not only in transplantology, but also in studies on the effectiveness of various immunosuppressive compounds and studies on autoimmune diseases, including diabetes, multiple sclerosis and albinism. The improved protocol of mouse tail skin grafting is easy to master, and its wide application gives many opportunities for new solutions in biomedical research..

scholarly journals Role of Regulatory Cells in Immune Tolerance Induction in Hemophilia A

HemaSphere ◽  
2021 ◽  
Vol 5 (5) ◽  
pp. e557
Author(s):  
Sarah J. Schep ◽  
Roger E. G. Schutgens ◽  
Kathelijn Fischer ◽  
Jan Voorberg ◽  
Marianne Boes
Keyword(s):  
Immune Tolerance ◽  
Hemophilia A ◽  
Tolerance Induction ◽  
Regulatory Cells ◽  
Immune Tolerance Induction

The Role of Immunomodulation in the Management of Factor VIII Inhibitors

Hematology ◽  
2006 ◽  
Vol 2006 (1) ◽  
pp. 421-425 ◽  
Author(s):  
David Lillicrap
Keyword(s):  
Prospective Trial ◽  
Tolerance Induction ◽  
Immunological Tolerance ◽  
Success Rates ◽  
Immune Tolerance Induction ◽  
Fviii Inhibitor ◽  
Risk Patients ◽  
Von Willebrand ◽  
Willebrand Factor

Abstract Approximately 25% of persons with hemophilia A will have their treatment complicated by the development of anti-FVIII inhibitory antibodies. This adverse event requires the use of alternative hemostatic agents to treat bleeding and the consideration of a protocol to generate immunological tolerance to FVIII. The pathogenetic factors contributing to FVIII inhibitor generation include both patient- and concentrate-related characteristics. The FVIII genotype contributes to this risk as do other, less well defined, immunogenetic factors. The role of the type of FVIII concentrate as a precipitant for inhibitor generation appears to be less influential. Immunomodulatory management of FVIII inhibitors requires sustained and repeated exposure to FVIII through a variety of intravenous immune tolerance induction (ITI) protocols. Certain pre-ITI characteristics predict for the likelihood of success, most especially the pre-ITI anti-FVIII inhibitor titer. Currently, two major areas of debate remain unresolved with relation to the optimal form of ITI schedule. The best FVIII dose to generate FVIII tolerance is under investigation in an international prospective trial, while the issue of whether von Willebrand factor–containing concentrates may provide more powerful tolerizing effects remains open for further discussion. With a variety of ITI protocols, success rates of approximately 80% have been achieved with good-risk patients. In those that fail initial attempts at ITI, additional treatments using agents such rituximab are now being explored with further evidence of success in 60–80% of these salvage patients. Finally, several pre-clinical studies of innovative approaches to achieving FVIII tolerance suggest that combinations of immunomodulatory therapy may be of benefit in the future.

scholarly journals Immune response to enzyme replacement therapies in lysosomal storage diseases and the role of immune tolerance induction

2016 ◽  
Vol 117 (2) ◽  
pp. 66-83 ◽  
Author(s):  
Priya S. Kishnani ◽  
Patricia I. Dickson ◽  
Laurie Muldowney ◽  
Jessica J. Lee ◽  
Amy Rosenberg ◽  
...  
Keyword(s):  
Immune Response ◽  
Immune Tolerance ◽  
Tolerance Induction ◽  
Lysosomal Storage Diseases ◽  
Lysosomal Storage ◽  
Immune Tolerance Induction ◽  
Storage Diseases ◽  
Enzyme Replacement

scholarly journals Immune Disorders in Hashimoto’s Thyroiditis: What Do We Know So Far?

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Aleksandra Pyzik ◽  
Ewelina Grywalska ◽  
Beata Matyjaszek-Matuszek ◽  
Jacek Roliński
Keyword(s):  
Hashimoto’S Thyroiditis ◽  
T Regulatory Cells ◽  
Hashimoto Thyroiditis ◽  
Hashimoto's Thyroiditis ◽  
Regulatory Cells ◽  
Review Of Literature ◽  
Immune Disorders ◽  
Cd4 Cells ◽  
Immune Defect

This review of literature attempts to identify the factors that are involved in the pathogenesis of Hashimoto thyroiditis, an immune defect in an individual with genetic susceptibility accompanied with environmental factors. The frequency of Hashimoto’s disease is a growing trend and among Caucasians it is estimated at approximately 5%. The dysfunction of the gland may be clinically evident (0.1–2% of the population) or subclinical (10–15%). The pathology is diagnosed five to ten times more often in women than men and its incidence increases with the age (the peak of the number of cases is between 45 and 65); however, it can also be diagnosed in children. The pathogenesis of Hashimoto’s thyroiditis is still not fully comprehended. In the etiology of Hashimoto thyroiditis excessively stimulated T CD4+ cells are known to play the most important role. Recent research has demonstrated an increasing role of newly discovered cells such as Th17 (CD4+IL-17+) or T regulatory cells (CD4+CD25+highFoxP3+) in the induction of autoimmune disorders. The process of programmed cell death also plays an equally important role in the pathogenesis and the development of hypothyroidism.

scholarly journals Pregnancy Epigenetic Signature in T Helper 17 and T Regulatory Cells in Multiple Sclerosis

2019 ◽  
Vol 9 ◽  
Author(s):  
Andrea Iannello ◽  
Simona Rolla ◽  
Alessandro Maglione ◽  
Giulio Ferrero ◽  
Valentina Bardina ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
T Regulatory Cells ◽  
Regulatory Cells ◽  
T Helper ◽  
T Helper 17

Interleukin-5 Therapy Prevents Chronic Allograft Rejection By Induction of T Regulatory Cells.

2014 ◽  
Vol 98 ◽  
pp. 403
Author(s):  
S. Hodgkinson ◽  
R. Hall ◽  
G. Tran ◽  
C. Robinson ◽  
C. Wang ◽  
...  
Keyword(s):  
Allograft Rejection ◽  
T Regulatory Cells ◽  
Regulatory Cells ◽  
Interleukin 5 ◽  
Chronic Allograft Rejection

The Critical Role of Induced CD4+ FoxP3+ Regulatory Cells in Suppression of Interleukin-17 Production and Attenuation of Mouse Orthotopic Lung Allograft Rejection

2015 ◽  
Vol 99 (7) ◽  
pp. 1356-1364 ◽  
Author(s):  
Wenyong Zhou ◽  
Xiaohui Zhou ◽  
Saren Gaowa ◽  
Qingshu Meng ◽  
Zhenzhen Zhan ◽  
...  
Keyword(s):  
Allograft Rejection ◽  
Critical Role ◽  
Interleukin 17 ◽  
Regulatory Cells
Sign in / Sign up

Export Citation Format

Share Document