scholarly journals Effect of controlled ventilation during assist-control ventilation on diaphragm thickness : a post hoc analysis of an observational study

2020 ◽  
Vol 67 (3.4) ◽  
pp. 332-337
Author(s):  
Taiga Itagaki ◽  
Nobuto Nakanishi ◽  
Takuya Takashima ◽  
Yoshitoyo Ueno ◽  
Natsuki Tane ◽  
...  
Keyword(s):  
Observational Study ◽  
Control Ventilation ◽  
Diaphragm Thickness ◽  
Post Hoc Analysis ◽  
Controlled Ventilation ◽  
Assist Control Ventilation ◽  
Post Hoc

Factors influencing mortality in atrial fibrillation. Post hoc analysis of an observational study in outpatients

2005 ◽  
Vol 103 (2) ◽  
pp. 140-144 ◽  
Author(s):  
Claudia Stöllberger ◽  
Maria Winkler-Dworak ◽  
Josef Finsterer ◽  
Elisabeth Hartl ◽  
Pavel Chnupa
Keyword(s):  
Atrial Fibrillation ◽  
Observational Study ◽  
Post Hoc Analysis ◽  
Factors Influencing ◽  
Post Hoc

scholarly journals Systemic Anticoagulant Effect of Low-Dose Subcutaneous Unfractionated Heparin as Determined Using Thrombelastography

2007 ◽  
Vol 35 (4) ◽  
pp. 498-504 ◽  
Author(s):  
S. J. Matzelle ◽  
N. M. Gibbs ◽  
W. Weightman ◽  
M. Sheminant ◽  
R. Rowe ◽  
...  
Keyword(s):  
Observational Study ◽  
Unfractionated Heparin ◽  
Low Dose ◽  
Anticoagulant Effect ◽  
Surgical Patients ◽  
Normal Range ◽  
Blood Samples ◽  
Post Hoc Analysis ◽  
Post Hoc ◽  
Preoperative Creatinine

In an observational study using heparinase-modified thrombelastography, we investigated the percentage of elective cardiothoracic surgical patients receiving low-dose unfractionated heparin (5000 IU 12 hourly subcutaneously) who had a demonstrable systemic heparin effect. Blood samples were obtained at induction from 40 adult elective cardiothoracic surgical patients who had received 5000 IU unfractionated heparin subcutaneously within six hours. Simultaneous kaolin and heparinase-modified thrombelastographies were run on all samples. Fourteen patients (35%; 95% CI: 20 to 50%) had a demonstrable heparin effect(defined as a kaolin thrombelastography R time >25% longer than the heparinase-modified control). Their mean±SD kaolin thrombelastography R time was 13.6±5.9 minutes (normal range 4 to 8 minutes) vs. 7.1±2.0 minutes for the heparinase-modified controls. In 10 patients the thrombelastography R times were >50% longer and in four patients >100% longer, than their respective heparinase-modified controls. In a post hoc analysis, there was little correlation between the extent of the prolongation and patient age (r=0.02), weight (r=-0.31), preoperative creatinine (r=-0.17), or time since administration of heparin (r=0.14). These results indicate that about one third of patients who have received low-dose unfractionated heparin subcutaneously within six hours have a demonstrable heparin effect. The potential for this effect should be considered if central neural blockade is planned.

scholarly journals Reliability and limits of transport-ventilators to safely ventilate severe patients in special surge situations

2020 ◽  
Author(s):  
Dominique Savary ◽  
Arnaud Lesimple ◽  
François Beloncle ◽  
François Morin ◽  
François Templier ◽  
...  
Keyword(s):  
Oxygen Pressure ◽  
Control Ventilation ◽  
Medical Systems ◽  
Test Lung ◽  
Trigger Time ◽  
Controlled Ventilation ◽  
Volume Controlled Ventilation ◽  
Assist Control Ventilation ◽  
Respiratory Conditions ◽  
Volume Controlled

AbstractBackgroundSeveral Intensive Care Units (ICU) have been overwhelmed by the surge of COVID-19 patients thus necessitating to extend ventilation capacity outside the ICU where air and oxygen pressure are not always available. Transport ventilators requiring only O2 source may be used to deliver volume-controlled ventilation.ObjectiveTo evaluate the performances of four transport ventilators compared to an ICU ventilator simulating severe respiratory conditions.Materials and methodsTwo pneumatic transport ventilators, (Oxylog 3000, Draeger; Osiris 3, Air Liquide Medical Systems) and two turbine transport ventilators (Elisee 350, ResMed; Monnal T60, Air Liquide Medical Systems) were compared to an ICU ventilator (Engström Carestation – GE Healthcare) using a Michigan training test lung. We tested each ventilator with different set volumes Vtset (350, 450, 550 ml) and different compliances (20 or 50 ml/cmH2O) and a resistance of 15 cmH2 0/L/sec based on values recently described in COVID-19 Acute Respiratory Distress Syndrome. Volume error was measured, as well as the trigger time delay during assist-control ventilation simulating spontaneous breathing activity with a P0.1 of 4 cmH20.ResultsGrouping all conditions, the volume error was 2.9 ± 2.2 % for Engström Carestation; 3.6 ± 3.9 % for Osiris 3; 2.5 ± 2.1 % for Oxylog 3000; 5.4 ± 2.7 % for Monnal T60 and 8.8 ± 4.8 % for Elisee 350. Grouping all conditions, trigger delay was 42 ± 4 ms, 65 ± 5 ms, 151 ± 14 ms, 51 ± 6 and 64 ± 5 ms for Engström Carestation, Osiris 3, Oxylog 3000, Monnal T60 and Elisee 350, respectively.ConclusionsIn special surge situations such as COVID-19 pandemic, most transport ventilators may be used to safely deliver volume-controlled ventilation in locations where only oxygen pressure supply is available with acceptable volume accuracy. Performances regarding triggering function are generally acceptable but vary across ventilators.

Nintedanib in IPF: post hoc analysis of the Italian FIBRONET observational study

2020 ◽  
Author(s):  
Venerino Poletti ◽  
Carlo Albera ◽  
Sergio Harari ◽  
Alberto Pesci ◽  
Alessandra Ori ◽  
...  
Keyword(s):  
Observational Study ◽  
Post Hoc Analysis ◽  
Post Hoc
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