scholarly journals Relationship between age-related decreases in serum 25-hydroxyvitamin D levels and skeletal muscle mass in Japanese women

2020 ◽  
Vol 67 (1.2) ◽  
pp. 151-157 ◽  
Author(s):  
Michiko Sato ◽  
Teruhiro Morishita ◽  
Takafumi Katayama ◽  
Shigeko Satomura ◽  
Hiroko Okuno ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Mass ◽  
Skeletal Muscle Mass ◽  
Japanese Women ◽  
Hydroxyvitamin D ◽  
Age Related ◽  
25 Hydroxyvitamin D

scholarly journals Relation of serum 25-hydroxyvitamin D status with skeletal muscle mass by sex and age group among Korean adults

2015 ◽  
Vol 114 (11) ◽  
pp. 1838-1844 ◽  
Author(s):  
Min Jung Ko ◽  
Sungha Yun ◽  
Kyungwon Oh ◽  
Kirang Kim
Keyword(s):  
Skeletal Muscle ◽  
Muscle Mass ◽  
Skeletal Muscle Mass ◽  
Age Groups ◽  
Mean Value ◽  
High Serum ◽  
Cross Sectional ◽  
Mean Values ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D

AbstractThe objective of this study was to examine whether high serum 25-hydroxyvitamin D (25(OH)D) concentration was associated with high skeletal muscle mass, taking into account the effects of sex and age among the participants of the Korea National Health and Nutrition Examination Survey (KNHANES) aged 40 years or older. This was a cross-sectional study using data from the 2009 to 2010 KNHANES; a total of 8406 subjects (3671 men and 4735 women) were included. The appendicular skeletal muscle mass index (ASMMI, kg/m2) was estimated to measure the skeletal muscle mass. Hypovitaminosis was classified when the level of serum 25(OH)D was <20 ng/ml. The general linear model adjusted for confounding factors was used to determine differences in means of ASMMI by 25(OH)D status. The mean values of ASMMI were higher for men when compared with women. Women had a greater proportion of hypovitaminosis (71·1 %) compared with men (53·2 %). After adjusting for multiple factors, men were seen to have significant differences in ASMMI based on 25(OH)D status regardless of age, showing a lower mean value of ASSMI in those with hypovitaminosis. However, there was no difference in ASMMI by 25(OH)D status among women in both younger and older age groups. In conclusion, we found that there might be a positive relationship between 25(OH)D and skeletal muscle mass in men, indicating that interventions to improve 25(OH)D levels that are aimed at increasing muscle mass could be beneficial for men with more rapid decreased rate of skeletal muscle mass.

scholarly journals Molecular Mechanism and Pathogenesis of Sarcopenia: An Overview

2021 ◽  
Vol 22 (6) ◽  
pp. 3032
Author(s):  
Anna Picca ◽  
Riccardo Calvani
Keyword(s):  
Skeletal Muscle ◽  
Molecular Mechanism ◽  
Muscle Mass ◽  
Skeletal Muscle Mass ◽  
Strength Function ◽  
Age Related

Sarcopenia involves a progressive age‐related decline of skeletal muscle mass and strength/function [...]

scholarly journals NEUROMUSCULAR CHANGES WITH AGING AND SARCOPENIA

2018 ◽  
pp. 1-3
Author(s):  
B.C. Clark
Keyword(s):  
Skeletal Muscle ◽  
Muscle Mass ◽  
Muscle Function ◽  
Skeletal Muscle Mass ◽  
The Past ◽  
Conceptual Definition ◽  
Age Related ◽  
Per Se ◽  
Definition Of ◽  
And Function

Sarcopenia was originally conceptualized as the age-related loss of skeletal muscle mass. Over the ensuing decades, the conceptual definition of sarcopenia has changed to represent a condition in older adults that is characterized by declining muscle mass and function, with “function” most commonly conceived as muscle weakness and/or impaired physical performance (e.g., slow gait speed). Findings over the past 15-years, however, have demonstrated that changes in grip and leg extensor strength are not primarily due to muscle atrophy per se, and that to a large extent, are reflective of declines in the integrity of the nervous system. This article briefly summarizes findings relating to the complex neuromuscular mechanisms that contribute to reductions in muscle function associated with advancing age, and the implications of these findings on the development of effective therapies.

Hurrah for the increasing longevity: feasible strategies to counteract age-related loss of skeletal muscle mass

2015 ◽  
Vol 25 (1) ◽  
pp. 1-2 ◽  
Author(s):  
L. Holm ◽  
A. P. Jespersen ◽  
D. S. Nielsen ◽  
M. B. Frøst ◽  
S. Reitelseder ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Mass ◽  
Skeletal Muscle Mass ◽  
Age Related

Aging, exercise, and muscle protein metabolism

2009 ◽  
Vol 106 (6) ◽  
pp. 2040-2048 ◽  
Author(s):  
René Koopman ◽  
Luc J. C. van Loon
Keyword(s):  
Physical Activity ◽  
Skeletal Muscle ◽  
Protein Synthesis ◽  
Food Intake ◽  
Muscle Mass ◽  
Skeletal Muscle Mass ◽  
Muscle Protein ◽  
Muscle Protein Synthesis ◽  
The Elderly ◽  
Age Related

Aging is accompanied by a progressive loss of skeletal muscle mass and strength, leading to the loss of functional capacity and an increased risk of developing chronic metabolic disease. The age-related loss of skeletal muscle mass is attributed to a disruption in the regulation of skeletal muscle protein turnover, resulting in an imbalance between muscle protein synthesis and degradation. As basal (fasting) muscle protein synthesis rates do not seem to differ substantially between the young and elderly, many research groups have started to focus on the muscle protein synthetic response to the main anabolic stimuli, i.e., food intake and physical activity. Recent studies suggest that the muscle protein synthetic response to food intake is blunted in the elderly. The latter is now believed to represent a key factor responsible for the age-related decline in skeletal muscle mass. Physical activity and/or exercise stimulate postexercise muscle protein accretion in both the young and elderly. However, the latter largely depends on the timed administration of amino acids and/or protein before, during, and/or after exercise. Prolonged resistance type exercise training represents an effective therapeutic strategy to augment skeletal muscle mass and improve functional performance in the elderly. The latter shows that the ability of the muscle protein synthetic machinery to respond to anabolic stimuli is preserved up to very old age. Research is warranted to elucidate the interaction between nutrition, exercise, and the skeletal muscle adaptive response. The latter is needed to define more effective strategies that will maximize the therapeutic benefits of lifestyle intervention in the elderly.

scholarly journals Clinical Characteristics of Geriatric Patients With Non-Specific Chronic Low Back Pain

2021 ◽  
Author(s):  
Yoshihito Sakai ◽  
Norimitsu Wakao ◽  
Hiroki Matsui ◽  
Tsuyoshi Watanabe ◽  
Hiroki Iida ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Mass ◽  
Skeletal Muscle Mass ◽  
Geriatric Patients ◽  
Whole Body ◽  
Composition Analysis ◽  
Sagittal Vertical Axis ◽  
Distribution Width ◽  
Age Related ◽  
Lumbar Degeneration

Abstract Although the prevalence and the associated burden of LBP increase with age, research on LBP has primarily focused on young people and adults, and little attention has been given to the elderly population. Chronic inflammation is well-known as senescence associated secretory phenotype (SASP), which produces numerous proinflammatory cytokines leading to age-related inflammation. We enrolled 203 patients with an average age of 79.0 years, with non-specific CLBP; the patients were compared with age- and sex-matched controls without CLBP using a propensity score-matched analysis. We performed laboratory analysis, radiographic evaluations for global spinal parameter and lumbar degeneration assessment, and body composition analysis using whole-body dual-energy X-ray absorptiometry. We observed a higher red blood cell distribution width (RDW), as well as a lower skeletal muscle mass index and a higher fat mass in patients with CLBP. Moreover, patients with geriatric CLBP had significantly lower lumbar lordosis, and higher sagittal vertical axis was correlated with lower muscle mass in the extremities and trunk, independent of lumbar degeneration. Geriatric CLBP is associated with senescence. RDW, which is an index of aging, was high among elderly patients with CLBP. Furthermore, geriatric patients with CLBP often have age-related skeletal muscle mass reduction and spinal sagittal malalignment.

scholarly journals Association between low muscle mass and metabolic syndrome in elderly Japanese women

PLoS ONE ◽  
2020 ◽  
Vol 15 (12) ◽  
pp. e0243242
Author(s):  
Kazushi Nomura ◽  
Masato Eto ◽  
Sumito Ogawa ◽  
Taro Kojima ◽  
Katsuya Iijima ◽  
...  
Keyword(s):  
Risk Factors ◽  
Skeletal Muscle ◽  
Metabolic Syndrome ◽  
Body Composition ◽  
Cardiovascular Risk ◽  
Muscle Mass ◽  
Skeletal Muscle Mass ◽  
Negative Relationship ◽  
Japanese Women ◽  
Older Adulthood

Metabolic syndrome (MetS) is an important predictor of mortality in older adulthood, but it is not reliably related to measures of body composition such as body mass index in older adults, as opposed to those in earlier life stages. Previous research suggests that skeletal muscle mass is related to cardiovascular risk in older adulthood, but it is difficult to measure muscle mass accurately and independently of body fat. This study aimed to examine the relationship between body composition and cardiovascular risk factors among women in older adulthood. A cross-sectional observational clinical study was conducted at a single medical clinic in Tokyo, Japan. Participants included 90 healthy Japanese women aged 65 years and older. MetS risk factors were assessed. Appendicular skeletal muscle mass (ASM) was assessed using dual-emission X-ray absorptiometry. Visceral fat area (VFA) was measured using computed tomography. VFA positively correlated with ASM and MetS, whereas ASM and MetS did not correlate with each other. Using VFA and ASM data in a MetS multiple linear regression model, the association between VFA and MetS remained positive, whereas a significant negative relationship emerged between ASM and MetS. Lower muscle mass was independently associated with higher cardiovascular risk after controlling for VFA. Clinical interventions to reduce muscle loss in older adulthood may be beneficial for reducing the risk of MetS and improving cardiovascular health.

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