scholarly journals Clinical outcomes and prognostic factors of definitive radiotherapy for esophageal cancer

2019 ◽  
Vol 66 (1.2) ◽  
pp. 99-105 ◽  
Author(s):  
Chisato Tonoiso ◽  
Hitoshi Ikushima ◽  
Akiko Kubo ◽  
Takashi Kawanaka ◽  
Shunsuke Funatani ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Prognostic Factors ◽  
Clinical Outcomes ◽  
Definitive Radiotherapy

scholarly journals Prognostic factors, patterns of recurrence and toxicity for patients with esophageal cancer undergoing definitive radiotherapy or chemo-radiotherapy

2015 ◽  
Vol 56 (4) ◽  
pp. 742-749 ◽  
Author(s):  
Matthias F. Haefner ◽  
Kristin Lang ◽  
David Krug ◽  
Stefan A. Koerber ◽  
Lorenz Uhlmann ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Prognostic Factors ◽  
Definitive Radiotherapy ◽  
Patterns Of Recurrence

scholarly journals Differences in Treatment Outcomes and Prognosis between Elderly and Younger Patients Receiving Definitive Radiotherapy for Cervical Cancer

2020 ◽  
Vol 17 (12) ◽  
pp. 4510
Author(s):  
PeiYu Hou ◽  
ChenHsi Hsieh ◽  
MingChow Wei ◽  
ShengMou Hsiao ◽  
PeiWei Shueng
Keyword(s):  
Cervical Cancer ◽  
Prognostic Factors ◽  
Elderly Patients ◽  
Treatment Outcomes ◽  
Clinical Outcomes ◽  
Age Groups ◽  
Definitive Radiotherapy ◽  
Regional Control ◽  
Group 2 ◽  
Two Age Groups

The aim was to compare the clinical outcomes and prognostic factors of cervical cancer between elderly and younger women, and to explore which treatment strategy is more appropriate for elderly patients. We retrospectively reviewed patients with cervical cancer receiving definitive radiotherapy (RT) between 2007 and 2016, and divided them into two age groups: age < 70 vs. age ≥ 70. The clinical outcomes were compared between the two age groups. The median follow-up was 32.2 months. A total of 123 patients were eligible, 83 patients in group 1 (age < 70), and 40 patients in group 2 (age ≥ 70). Patients in group 2 received less intracavitary brachytherapy (ICRT) application, less total RT dose, and less concurrent chemoradiotherapy (CCRT), and tended to have more limited external beam radiotherapy (EBRT) volume. The treatment outcomes between the age groups revealed significant differences in 5-year overall survival (OS), but no differences in 5-year cancer-specific survival (CSS), 66.2% vs. 64.5%, and other loco-regional control. In multivariate analyses for all patients, the performance status, pathology with squamous cell carcinoma (SCC), International Federation of Gynecology and Obstetrics (FIGO) stage, and ICRT application were prognostic factors of CSS. The elderly patients with cervical cancer had comparable CSS and loco-regional control rates, despite receiving less comprehensive treatment. Conservative treatment strategies with RT alone could be appropriate for patients aged ≥ 70 y/o, especially for those with favorable stages or histopathology.

scholarly journals Patterns of failure and clinical outcomes of definitive radiotherapy for cervical esophageal cancer

Oncotarget ◽  
2017 ◽  
Vol 8 (13) ◽  
pp. 21852-21860 ◽  
Author(s):  
Lina Zhao ◽  
Yongchun Zhou ◽  
Yunfeng Mu ◽  
Guangjin Chai ◽  
Feng Xiao ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Clinical Outcomes ◽  
Cervical Esophageal Cancer ◽  
Patterns Of Failure ◽  
Definitive Radiotherapy

scholarly journals Outcomes and prognostic factors for patients with cervical esophageal cancer undergoing definitive radiotherapy or chemoradiotherapy

2019 ◽  
Author(s):  
Xin-xin Du ◽  
Rong Yu ◽  
Zhen-fei Wang ◽  
De-cheng Du ◽  
Qiao-yun Liu ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Radiation Therapy ◽  
Prognostic Factors ◽  
Prognostic Factor ◽  
Clinical Stage ◽  
Independent Prognostic Factor ◽  
Tumor Control ◽  
Cervical Esophageal Cancer ◽  
Free Survival ◽  
Definitive Radiotherapy

Cervical esophageal cancer (CEC) is uncommon, accounting for less than 5% of all esophageal cancers. The management of CEC is controversial. This study investigated treatment outcomes and prognostic factors of survival in CEC patients undergoing definitive radiotherapy or concurrent chemoradiotherapy (CCRT). Ninety-one CEC patients were treated by intensity-modulated radiation therapy (IMRT) and three-dimensional conformal radiation therapy (3DCRT) between July 2007 and September 2017. The mean prescription dose was 64 Gy (range 54-70 Gy) delivered as 1.8-2.2 Gy per fraction per day, 5 days a week. Out of 91 patients, 34 received concurrent cisplatin-based chemotherapy (CT) including 18 patients who also received neoadjuvant CT. Overall survival (OS), locoregional failure-free survival (LRFFS), and progression-free survival (PFS) were estimated by the Kaplan–Meier method. Prognostic factors of survival were determined in univariate (log-rank test) and multivariate (Cox proportional hazard model) analysis. Treatment-related toxicity was also assessed. Median follow-up time for all patients was 19 months. Two-year OS, LRFFS and PFS of all patients were 58.2%, 52.5% and 48.1%, respectively. Clinical stage was an independent prognostic factor for OS (HR = 2.35, 95% CI: 1.03-5.37, p = 0.042), LRFFS (HR = 3.84, 95% CI: 1.38-10.69, p = 0.011), and PFS (HR = 2.68, 95% CI: 1.11-6.45, p = 0.028). Hoarseness was an independent prognostic factor for OS (HR = 2.10, 95% CI: 1.05-4.19, p = 0.036). CCRT was independently associated with better LRFFS (HR = 0.33, 95% CI: 0.14-0.79, p = 0.012). 3DCRT and IMRT with concurrent CT is well-tolerated and may improve local tumor control in CEC patients. Advanced clinical stage and hoarseness are adverse prognostic factors for OS, LRFFS, and PFS in CEC.

scholarly journals Prognostic Factors for Patients with Esophageal Cancer Receiving Definitive Radiotherapy Alone: A Retrospective Analysis

2021 ◽  
Vol Volume 13 ◽  
pp. 3229-3234
Author(s):  
Nan Jiang ◽  
Xiao-Lin Ge ◽  
Zhao-Yue Zhang ◽  
Jia Liu ◽  
Pei-Pei Wang ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Prognostic Factors ◽  
Retrospective Analysis ◽  
Definitive Radiotherapy ◽  
Radiotherapy Alone

scholarly journals Interobserver variability in target volume delineation in definitive radiotherapy for thoracic esophageal cancer: a multi-center study from China

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Xiao Chang ◽  
Wei Deng ◽  
Xin Wang ◽  
Zongmei Zhou ◽  
Jun Yang ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Gross Tumor Volume ◽  
Tumor Volume ◽  
Interobserver Variability ◽  
Target Volume ◽  
Thoracic Esophageal Cancer ◽  
Target Volume Delineation ◽  
Cancer Centers ◽  
Definitive Radiotherapy ◽  
Volume Delineation

Abstract Purpose To investigate the interobserver variability (IOV) in target volume delineation of definitive radiotherapy for thoracic esophageal cancer (TEC) among cancer centers in China, and ultimately improve contouring consistency as much as possible to lay the foundation for multi-center prospective studies. Methods Sixteen cancer centers throughout China participated in this study. In Phase 1, three suitable cases with upper, middle, and lower TEC were chosen, and participants were asked to contour a group of gross tumor volume (GTV-T), nodal gross tumor volume (GTV-N) and clinical target volume (CTV) for each case based on their routine experience. In Phase 2, the same clinicians were instructed to follow a contouring protocol to re-contour another group of target volume. The variation of the target volume was analyzed and quantified using dice similarity coefficient (DSC). Results Sixteen clinicians provided routine volumes, whereas ten provided both routine and protocol volumes for each case. The IOV of routine GTV-N was the most striking in all cases, with the smallest DSC of 0.37 (95% CI 0.32–0.42), followed by CTV, whereas GTV-T showed high consistency. After following the protocol, the smallest DSC of GTV-N was improved to 0.64 (95% CI 0.45–0.83, P = 0.005) but the DSC of GTV-T and CTV remained constant in most cases. Conclusion Variability in target volume delineation was observed, but it could be significantly reduced and controlled using mandatory interventions.

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