scholarly journals Gait and posture assessments of a patient treated with deep brain stimulation in dystonia using three-dimensional motion analysis systems

2011 ◽  
Vol 58 (3,4) ◽  
pp. 264-272 ◽  
Author(s):  
Shigetaka Nakao ◽  
Koji Komatsu ◽  
Waka Sakai ◽  
Michiharu Kashihara ◽  
Yuki Masuda ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Motion Analysis ◽  
Brain Stimulation ◽  
Three Dimensional ◽  
Deep Brain

scholarly journals Towards Tracking of Deep Brain Stimulation Electrodes Using an Integrated Magnetometer

Sensors ◽  
2021 ◽  
Vol 21 (8) ◽  
pp. 2670
Author(s):  
Thomas Quirin ◽  
Corentin Féry ◽  
Dorian Vogel ◽  
Céline Vergne ◽  
Mathieu Sarracanie ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Mean Absolute Error ◽  
Tracking System ◽  
Three Dimensional ◽  
Absolute Error ◽  
Magnetic Tracking ◽  
Magnetic Camera ◽  
Magnetic Resonance Imaging Mri ◽  
Deep Brain

This paper presents a tracking system using magnetometers, possibly integrable in a deep brain stimulation (DBS) electrode. DBS is a treatment for movement disorders where the position of the implant is of prime importance. Positioning challenges during the surgery could be addressed thanks to a magnetic tracking. The system proposed in this paper, complementary to existing procedures, has been designed to bridge preoperative clinical imaging with DBS surgery, allowing the surgeon to increase his/her control on the implantation trajectory. Here the magnetic source required for tracking consists of three coils, and is experimentally mapped. This mapping has been performed with an in-house three-dimensional magnetic camera. The system demonstrates how magnetometers integrated directly at the tip of a DBS electrode, might improve treatment by monitoring the position during and after the surgery. The three-dimensional operation without line of sight has been demonstrated using a reference obtained with magnetic resonance imaging (MRI) of a simplified brain model. We observed experimentally a mean absolute error of 1.35 mm and an Euclidean error of 3.07 mm. Several areas of improvement to target errors below 1 mm are also discussed.

Database of MNI stereotactic coordinates for deep brain stimulation targets in neuropsychiatric disorders

2011 ◽  
Vol 26 (S2) ◽  
pp. 1149-1149
Author(s):  
U. Moser ◽  
M. Savli ◽  
R. Lanzenberger ◽  
S. Kasper
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Functional Neuroimaging ◽  
Case Reports ◽  
Three Dimensional ◽  
Compulsive Disorder ◽  
Neuroimaging Data ◽  
Specific Disorders ◽  
Image Position ◽  
Deep Brain

IntroductionDeep brain stimulation (DBS) is a promising therapy option for otherwise treatment-resistant neuropsychiatrie disorders, especially in obsessive-compulsive disorder (OCD), major depression (TRD) and Tourette's Syndrome (TS).ObjectiveThe brain coordinates of the DBS targets are mainly reported using measurements in original, unnormalized brains. In the neuroimaging community stereotactic data are mainly indicated in the standardized Montreal Neurological Institute (MNI) space, i.e. a three-dimensional proportional grid system.AimsImproved comparability between targets in DBS studies and molecular and functional neuroimaging data from PET, SPECT, MRI, fMRI, mostly published with stereotactic data.MethodsA comprehensive and systematic literature search for published DBS case reports or studies in TRD, OCD and TS was performed. We extracted the tip positions of electrode leads as provided in the publications or by the authors, and transferred individual coordinates to the standard brain in the MNI space.Results46 publications fulfilled the inclusion criteria. The main targets for the specific disorders and one or two examples of their calculated MNI coordinates are indicated in the table:[MNI coordinates of the main DBS targets]ConclusionsWe provide DBS data of neuropsychiatrie disorders in the MNI space, improving the comparability to molecular, functional and structural neuroimaging data.

scholarly journals Quantifying the Neural Elements Activated and Inhibited by Globus Pallidus Deep Brain Stimulation

2008 ◽  
Vol 100 (5) ◽  
pp. 2549-2563 ◽  
Author(s):  
Matthew D. Johnson ◽  
Cameron C. McIntyre
Keyword(s):  
Deep Brain Stimulation ◽  
Globus Pallidus ◽  
Brain Stimulation ◽  
Network Effects ◽  
Relative Proportion ◽  
Three Dimensional ◽  
Electrode Placement ◽  
Stimulation Parameter ◽  
Pars Interna ◽  
Deep Brain

Deep brain stimulation (DBS) of the globus pallidus pars interna (GPi) is an effective therapy option for controlling the motor symptoms of medication-refractory Parkinson's disease and dystonia. Despite the clinical successes of GPi DBS, the precise therapeutic mechanisms are unclear and questions remain on the optimal electrode placement and stimulation parameter selection strategies. In this study, we developed a three-dimensional computational model of GPi-DBS in nonhuman primates to investigate how membrane channel dynamics, synaptic inputs, and axonal collateralization contribute to the neural responses generated during stimulation. We focused our analysis on three general neural elements that surround GPi-DBS electrodes: GPi somatodendritic segments, GPi efferent axons, and globus pallidus pars externa (GPe) fibers of passage. During high-frequency electrical stimulation (136 Hz), somatic activity in the GPi showed interpulse excitatory phases at 1–3 and 4–5.5 ms. When including stimulation-induced GABAA and AMPA receptor dynamics into the model, the somatic firing patterns continued to be entrained to the stimulation, but the overall firing rate was reduced (78.7 to 25.0 Hz, P < 0.001). In contrast, axonal output from GPi neurons remained largely time-locked to each pulse of the stimulation train. Similar entrainment was also observed in GPe efferents, a majority of which have been shown to project through GPi en route to the subthalamic nucleus. The models suggest that pallidal DBS may have broader network effects than previously realized and the modes of therapy may depend on the relative proportion of GPi and/or GPe efferents that are directly affected by the stimulation.

Computational Analysis of Subthalamic Nucleus and Lenticular Fasciculus Activation During Therapeutic Deep Brain Stimulation

2006 ◽  
Vol 96 (3) ◽  
pp. 1569-1580 ◽  
Author(s):  
Svjetlana Miocinovic ◽  
Martin Parent ◽  
Christopher R. Butson ◽  
Philip J. Hahn ◽  
Gary S. Russo ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Subthalamic Nucleus ◽  
Brain Stimulation ◽  
Three Dimensional ◽  
Internal Capsule ◽  
Element Model ◽  
Projection Neurons ◽  
Anatomical Model ◽  
Stn Dbs ◽  
Deep Brain

The subthalamic nucleus (STN) is the most common target for the treatment of Parkinson’s disease (PD) with deep brain stimulation (DBS). DBS of the globus pallidus internus (GPi) is also effective in the treatment of PD. The output fibers of the GPi that form the lenticular fasciculus pass in close proximity to STN DBS electrodes. In turn, both STN projection neurons and GPi fibers of passage represent possible therapeutic targets of DBS in the STN region. We built a comprehensive computational model of STN DBS in parkinsonian macaques to study the effects of stimulation in a controlled environment. The model consisted of three fundamental components: 1) a three-dimensional (3D) anatomical model of the macaque basal ganglia, 2) a finite element model of the DBS electrode and electric field transmitted to the tissue medium, and 3) multicompartment biophysical models of STN projection neurons, GPi fibers of passage, and internal capsule fibers of passage. Populations of neurons were positioned within the 3D anatomical model. Neurons were stimulated with electrode positions and stimulation parameters defined as clinically effective in two parkinsonian monkeys. The model predicted axonal activation of STN neurons and GPi fibers during STN DBS. Model predictions regarding the degree of GPi fiber activation matched well with experimental recordings in both monkeys. Only axonal activation of the STN neurons showed a statistically significant increase in both monkeys when comparing clinically effective and ineffective stimulation. Nonetheless, both neural targets may play important roles in the therapeutic mechanisms of STN DBS.

Development and Characterization of Multisite Three-Dimensional Microprobes for Deep Brain Stimulation and Recording

2011 ◽  
Vol 20 (5) ◽  
pp. 1109-1118 ◽  
Author(s):  
Arash A. Fomani ◽  
Raafat R. Mansour ◽  
Carlos M. Florez-Quenguan ◽  
Peter L. Carlen
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Three Dimensional ◽  
Deep Brain

Postoperative Displacement of Deep Brain Stimulation Electrodes Related to Lead-Anchoring Technique

Neurosurgery ◽  
2013 ◽  
Vol 73 (4) ◽  
pp. 681-688 ◽  
Author(s):  
M. Fiorella Contarino ◽  
Maarten Bot ◽  
Johannes D. Speelman ◽  
Rob M. A. de Bie ◽  
Marina A. Tijssen ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Three Dimensional ◽  
Fixation Method ◽  
Compulsive Disorder ◽  
Long Term Follow Up ◽  
Electrode Displacement ◽  
Deep Brain

Abstract BACKGROUND: Displacement of deep brain stimulation (DBS) electrodes may occur after surgery, especially due to large subdural air collections, but other factors might contribute. OBJECTIVE: To investigate factors potentially contributing to postoperative electrode displacement, in particular, different lead-anchoring techniques. METHODS: We retrospectively analyzed 55 patients (106 electrodes) with Parkinson disease, dystonia, tremor, and obsessive-compulsive disorder in whom early postoperative and long-term follow-up computed tomography (CT) was performed. Electrodes were anchored with a titanium microplate or with a commercially available plastic cap system. Two independent examiners determined the stereotactic coordinates of the deepest DBS contact on early postoperative and long-term follow-up CT. The influence of age, surgery duration, subdural air volume, use of microrecordings, fixation method, follow-up time, and side operated on first was assessed. RESULTS: Subdural air collections measured on average 4.3 ± 6.2 cm3. Three-dimensional (3-D) electrode displacement and displacement in the X, Y, and Z axes significantly correlated only with the anchoring method, with larger displacement for microplate-anchored electrodes. The average 3-D displacement for microplate-anchored electrodes was 2.3 ± 2.0 mm vs 1.5 ± 0.6 mm for electrodes anchored with the plastic cap (P = .030). Fifty percent of the microplate-anchored electrodes showed 2-mm or greater (potentially relevant) 3-D displacement vs only 25% of the plastic cap–anchored electrodes (P &lt; .01). CONCLUSION: The commercially available plastic cap system is more efficient in preventing postoperative DBS electrode displacement than titanium microplates. A reliability analysis of the electrode fixation is warranted when alternative anchoring methods are used.

Three-dimensional localization of cortical electrodes in deep brain stimulation surgery from intraoperative fluoroscopy

NeuroImage ◽  
2016 ◽  
Vol 125 ◽  
pp. 515-521 ◽  
Author(s):  
Michael J. Randazzo ◽  
Efstathios D. Kondylis ◽  
Ahmad Alhourani ◽  
Thomas A. Wozny ◽  
Witold J. Lipski ◽  
...  
Keyword(s):  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Three Dimensional ◽  
Intraoperative Fluoroscopy ◽  
Deep Brain Stimulation Surgery ◽  
Deep Brain
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