scholarly journals Elucidation of the molecular signatures of renal cell carcinoma by gene expression profiling

2006 ◽  
Vol 53 (1,2) ◽  
pp. 9-19 ◽  
Author(s):  
Masayuki Takahashi ◽  
Bin T. Teh ◽  
Hiro-omi Kanayama
Keyword(s):  
Gene Expression ◽  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Gene Expression Profiling ◽  
Expression Profiling ◽  
Renal Cell ◽  
Molecular Signatures

scholarly journals Combining differential expression, chromosomal and pathway analyses for the molecular characterization of renal cell carcinoma

2012 ◽  
Vol 1 (2S) ◽  
Author(s):  
Kyle A. Furge ◽  
Karl Dykema ◽  
David Petillo ◽  
Michael Westphal ◽  
Zhongfa Zhang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Gene Expression Profiling ◽  
Cancer Cells ◽  
Expression Profiling ◽  
Renal Cell ◽  
Molecular Signatures ◽  
Genetic Makeup ◽  
Papillary Rcc

Using high-throughput gene-expression profiling technology, we can now gaina better understanding of the complex biology that is taking place in cancer cells. This complexity is largely dictated by the abnormal genetic makeup ofthe cancer cells. This abnormal genetic makeup can have profound effectson cellular activities such as cell growth, cell survival and other regulatory processes. Based on the pattern of gene expression, or molecular signatures of the tumours, we can distinguish or subclassify different types of cancers according to their cell of origin, behaviour, and the way they respond to therapeuticagents and radiation. These approaches will lead to better molecularsubclassification of tumours, the basis of personalized medicine. We have, todate, done whole-genome microarray gene-expression profiling on several hundredsof kidney tumours. We adopt a combined bioinformatic approach, based on an integrative analysis of the gene-expression data. These data are used toidentify both cytogenetic abnormalities and molecular pathways that are deregulatedin renal cell carcinoma (RCC). For example, we have identified the deregulationof the VHL-hypoxia pathway in clear-cell RCC, as previously known,and the c-Myc pathway in aggressive papillary RCC. Besides the more commonclear-cell, papillary and chromophobe RCCs, we are currently characterizingthe molecular signatures of rarer forms of renal neoplasia such ascarcinoma of the collecting ducts, mixed epithelial and stromal tumours, chromosomeXp11 translocations associated with papillary RCC, renal medullarycarcinoma, mucinous tubular and spindle-cell carcinoma, and a group of unclassified tumours. Continued development and improvement in the field of molecular profiling will better characterize cancer and provide more accurate diagnosis, prognosis and prediction of drug response.

Gene expression profiling of renal cell carcinoma: a DNA macroarray analysis

2006 ◽  
Vol 98 (1) ◽  
pp. 205-216 ◽  
Author(s):  
JON A.J. LOVISOLO ◽  
BARBARA CASATI ◽  
LIBERO CLERICI ◽  
ERMINIO MARAFANTE ◽  
ALDO V. BONO ◽  
...  
Keyword(s):  
Gene Expression ◽  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Gene Expression Profiling ◽  
Expression Profiling ◽  
Renal Cell ◽  
Macroarray Analysis

scholarly journals Microarray gene expression profiling and analysis in renal cell carcinoma

BMC Urology ◽  
2004 ◽  
Vol 4 (1) ◽  
Author(s):  
Louis S Liou ◽  
Ting Shi ◽  
Zhong-Hui Duan ◽  
Provash Sadhukhan ◽  
Sandy D Der ◽  
...  
Keyword(s):  
Gene Expression ◽  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Gene Expression Profiling ◽  
Expression Profiling ◽  
Renal Cell ◽  
Microarray Gene Expression ◽  
Microarray Gene

scholarly journals Comparative Gene Expression Profiling of Primary and Metastatic Renal Cell Carcinoma Stem Cell-Like Cancer Cells

PLoS ONE ◽  
2016 ◽  
Vol 11 (11) ◽  
pp. e0165718 ◽  
Author(s):  
Mohammed I. Khan ◽  
Anna M. Czarnecka ◽  
Sławomir Lewicki ◽  
Igor Helbrecht ◽  
Klaudia Brodaczewska ◽  
...  
Keyword(s):  
Gene Expression ◽  
Renal Cell Carcinoma ◽  
Stem Cell ◽  
Cell Carcinoma ◽  
Gene Expression Profiling ◽  
Cancer Cells ◽  
Metastatic Renal Cell Carcinoma ◽  
Expression Profiling ◽  
Renal Cell
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