scholarly journals The Cytoplasmic Region of Plasmodium falciparum SURFIN4.2 Is Required for Transport from Maurer’s Clefts to the Red Blood Cell Surface

2015 ◽  
Vol 43 (4) ◽  
pp. 265-272 ◽  
Author(s):  
Wataru Kagaya ◽  
Shinya Miyazaki ◽  
Kazuhide Yahata ◽  
Nobuo Ohta ◽  
Osamu Kaneko
Keyword(s):  
Plasmodium Falciparum ◽  
Cell Surface ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Cytoplasmic Region ◽  
Maurer's Clefts

scholarly journals Virulence determinant, PTP7, controls vesicle budding from the Maurer’s clefts, adhesin protein trafficking and host cell remodeling in Plasmodium falciparum

2021 ◽  
Author(s):  
Olivia M. S. Carmo ◽  
Gerald J Shami ◽  
Dezerae Cox ◽  
Boyin Liu ◽  
Adam J Blanch ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Cell Surface ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Protein Trafficking ◽  
Low Complexity ◽  
Vesicle Budding ◽  
Cell Remodeling ◽  
Virulence Protein ◽  
Maurer's Clefts

Presentation of the variant antigen, Plasmodium falciparum erythrocyte membrane protein 1 (EMP1), at knob-like protrusions on the surface of infected red blood cells, underpins P. falciparum malaria pathogenicity. Here we describe a protein PF3D7_0301700 (PTP7), that functions at the nexus between the intermediate trafficking organelle, the Maurer’s cleft, and the red blood cell surface. Genetic disruption of PTP7 leads to accumulation of vesicles at the Maurer’s clefts, grossly aberrant knob morphology, and failure to deliver EMP1 to the red blood cell surface.  We show that an expanded low complexity sequence in the C-terminal region of PTP7, found only in the Laverania clade of Plasmodium , is critical for efficient virulence protein trafficking.

scholarly journals Antibodies in children with malaria to PfEMP1, RIFIN and SURFIN expressed at the Plasmodium falciparum parasitized red blood cell surface

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Maria del Pilar Quintana ◽  
Jun-Hong Ch’ng ◽  
Kirsten Moll ◽  
Arash Zandian ◽  
Peter Nilsson ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Cell Surface ◽  
Blood Cell ◽  
Red Blood Cell

scholarly journals PEXEL-independent trafficking of Plasmodium falciparum SURFIN4.2 to the parasite-infected red blood cell and Maurer's clefts

2011 ◽  
Vol 60 (3) ◽  
pp. 313-320 ◽  
Author(s):  
Jean Semé Fils Alexandre ◽  
Kazuhide Yahata ◽  
Satoru Kawai ◽  
Motomi Torii ◽  
Osamu Kaneko
Keyword(s):  
Plasmodium Falciparum ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Maurer's Clefts

scholarly journals Plasmodium falciparum SURFIN4.1 forms an intermediate complex with PTEX components and Pf113 during export to the red blood cell

2021 ◽  
Vol 83 ◽  
pp. 102358
Author(s):  
Shinya Miyazaki ◽  
Ben-Yeddy Abel Chitama ◽  
Wataru Kagaya ◽  
Amuza Byaruhanga Lucky ◽  
Xiaotong Zhu ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Intermediate Complex

The RhopH complex is transferred to the host cell cytoplasm following red blood cell invasion by Plasmodium falciparum

2008 ◽  
Vol 160 (2) ◽  
pp. 81-89 ◽  
Author(s):  
Laetitia Vincensini ◽  
Gamou Fall ◽  
Laurence Berry ◽  
Thierry Blisnick ◽  
Catherine Braun Breton
Keyword(s):  
Plasmodium Falciparum ◽  
Blood Cell ◽  
Host Cell ◽  
Cell Invasion ◽  
Red Blood Cell ◽  
Cell Cytoplasm ◽  
Host Cell Cytoplasm

scholarly journals EFFECT OF ARABICA AND CANEPHORA COFFEE BEAN EXTRACTS TOWARDS MODIFICATION OF RED BLOOD CELL SURFACE ANTIGENS

2018 ◽  
Vol 9 (5) ◽  
pp. 91-95 ◽  
Author(s):  
Praveen Kumar Vemuri ◽  
Sanjay Madala ◽  
Vijaya Lakshmi Bodiga ◽  
Suryanarayana Veeravalli ◽  
Nithin Chand Kurra
Keyword(s):  
Cell Surface ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Surface Antigens ◽  
Coffee Bean ◽  
Cell Surface Antigens

scholarly journals Plasmodium falciparum erythrocyte-binding antigen 175 triggers a biophysical change in the red blood cell that facilitates invasion

2017 ◽  
Vol 114 (16) ◽  
pp. 4225-4230 ◽  
Author(s):  
Marion Koch ◽  
Katherine E. Wright ◽  
Oliver Otto ◽  
Maik Herbig ◽  
Nichole D. Salinas ◽  
...  
Keyword(s):  
Cell Surface ◽  
Blood Cell ◽  
Signaling Pathways ◽  
Red Blood Cell ◽  
Malaria Parasite ◽  
Red Cell ◽  
Biophysical Properties ◽  
Parasite Invasion ◽  
Bending Modulus ◽  
Erythrocyte Binding

Invasion of the red blood cell (RBC) by the Plasmodium parasite defines the start of malaria disease pathogenesis. To date, experimental investigations into invasion have focused predominantly on the role of parasite adhesins or signaling pathways and the identity of binding receptors on the red cell surface. A potential role for signaling pathways within the erythrocyte, which might alter red cell biophysical properties to facilitate invasion, has largely been ignored. The parasite erythrocyte-binding antigen 175 (EBA175), a protein required for entry in most parasite strains, plays a key role by binding to glycophorin A (GPA) on the red cell surface, although the function of this binding interaction is unknown. Here, using real-time deformability cytometry and flicker spectroscopy to define biophysical properties of the erythrocyte, we show that EBA175 binding to GPA leads to an increase in the cytoskeletal tension of the red cell and a reduction in the bending modulus of the cell’s membrane. We isolate the changes in the cytoskeleton and membrane and show that reduction in the bending modulus is directly correlated with parasite invasion efficiency. These data strongly imply that the malaria parasite primes the erythrocyte surface through its binding antigens, altering the biophysical nature of the target cell and thus reducing a critical energy barrier to invasion. This finding would constitute a major change in our concept of malaria parasite invasion, suggesting it is, in fact, a balance between parasite and host cell physical forces working together to facilitate entry.

Simultaneous Camouflage of Major and Minor Antigens on Red Blood Cell Surface With Activated mPEGs

2014 ◽  
Vol 12 (2) ◽  
Author(s):  
Zahra Gholami ◽  
Sameereh Hashemi Najafabadi ◽  
Masoud Soleimani
Keyword(s):  
Cell Surface ◽  
Blood Cell ◽  
Red Blood Cell
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