scholarly journals DIFFUSION TENSOR IMAGING OF OPTIC RADIATION IN MULTIPLE SCLEROSIS: CORRELATION WITH VEP.

2018 ◽  
Vol 6 (7) ◽  
pp. 865-871
Author(s):  
AzzaElMonguiEl Mongui ◽  
Keyword(s):  
Multiple Sclerosis ◽  
Diffusion Tensor Imaging ◽  
Diffusion Tensor ◽  
Optic Radiation

scholarly journals Diffusion tensor imaging of occult injury of optic radiation following optic neuritis in multiple sclerosis

2016 ◽  
Vol 12 (4) ◽  
pp. 2505-2510 ◽  
Author(s):  
Jiafeng Chen ◽  
Lijun Zhu ◽  
He Li ◽  
Ziwen Lu ◽  
Xin Chen ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Diffusion Tensor Imaging ◽  
Optic Neuritis ◽  
Diffusion Tensor ◽  
Optic Radiation

scholarly journals Using diffusion tensor imaging and immunofluorescent assay to evaluate the pathology of multiple sclerosis

2011 ◽  
Vol 33 (3) ◽  
pp. 557-564 ◽  
Author(s):  
Lauren V. Zollinger ◽  
Tae Ho Kim ◽  
Kenneth Hill ◽  
Eun K. Jeong ◽  
John W. Rose
Keyword(s):  
Multiple Sclerosis ◽  
Diffusion Tensor Imaging ◽  
Diffusion Tensor ◽  
Immunofluorescent Assay

Exploring mania-associated white matter injury by comparison with multiple sclerosis: a diffusion tensor imaging study

2018 ◽  
Vol 281 ◽  
pp. 78-84 ◽  
Author(s):  
Niccolò Piaggio ◽  
Simona Schiavi ◽  
Matteo Martino ◽  
Giulia Bommarito ◽  
Matilde Inglese ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Diffusion Tensor ◽  
Imaging Study ◽  
White Matter Injury ◽  
Diffusion Tensor Imaging Study

scholarly journals Stereotactic diffusion tensor imaging tractography for Gamma Knife radiosurgery

2016 ◽  
Vol 125 (Supplement_1) ◽  
pp. 139-146 ◽  
Author(s):  
Cormac G. Gavin ◽  
H. Ian Sabin
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Stereotactic Radiosurgery ◽  
Treatment Planning ◽  
Vestibular Schwannoma ◽  
Diffusion Tensor ◽  
Gamma Knife Radiosurgery ◽  
Optic Radiation ◽  
Arcuate Fasciculus ◽  
Stereotactic Frame

OBJECTIVEThe integration of modern neuroimaging into treatment planning has increased the therapeutic potential and safety of stereotactic radiosurgery. The authors report their method of integrating stereotactic diffusion tensor imaging (DTI) tractography into conventional treatment planning for Gamma Knife radiosurgery (GKRS). The aim of this study was to demonstrate the feasibility of this technique and to address some of the technical limitations of previously reported techniques.METHODSTwenty patients who underwent GKRS composed the study cohort. They consisted of 1 initial test case (a patient with a vestibular schwannoma), 5 patients with arteriovenous malformations, 9 patients with cerebral metastases, 1 patient with parasagittal meningioma, and 4 patients with vestibular schwannoma. DT images were obtained at the time of standard GKRS protocol MRI (T1 and T2 weighted) for treatment, with the patient's head secured by a Leksell stereotactic frame. All studies were performed using a 1.5-T magnet with a single-channel head coil. DTI was performed with diffusion gradients in 32 directions and coregistered with the volumetric T1-weighted study. DTI postprocessing by means of commercially available software allowed tensor computation and the creation of directionally encoded color–, apparent diffusion coefficient–, and fractional anisotropy–mapped sequences. In addition, the software allowed visualized critical tracts to be exported as a structural volume and integrated into GammaPlan as an “organ at risk” during shot planning. Combined images were transferred to GammaPlan and integrated into treatment planning.RESULTSStereotactic DT images were successfully acquired in all patients, with generation of correct directionally encoded color images. Tract generation with the software was straightforward and reproducible, particularly for axial tracts such as the optic radiation and the arcuate fasciculus. Corticospinal tract visualization was hampered by some artifacts from the base of the stereotactic frame, but this was overcome by a combination of frame/MRI volume adjustment and DTI seeding parameters. Coregistration of the DTI series with the T1-weighted treatment volume at the time of imaging was essential for the generation of correct tensor data. All patients with the exception of the vestibular schwannoma cases had treatment pathology in the vicinity of eloquent tracts and/or the cortex. No new neurological deficits due to radiation were recorded at the short-term follow-up.CONCLUSIONSRecent reports in the medical literature have suggested that white matter tracts (particularly the optic radiation and arcuate fasciculus) are more vulnerable to radiation during stereotactic radiosurgery than previously thought. Integration of stereotactic tractography into GKRS represents a promising tool for preventing GKRS complications by reduction in radiation doses to functional organs at risk, including critical cortical areas and subcortical white matter tracts.

Diffusion tensor imaging in multiple sclerosis: a tool for monitoring changes in normal-appearing white matter

2004 ◽  
Vol 10 (2) ◽  
pp. 188-196 ◽  
Author(s):  
Emmanuelle Cassol ◽  
Jean-Philippe Ranjeva ◽  
Danielle Ibarrola ◽  
Claude Mékies ◽  
Claude Manelfe ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Diffusion Tensor ◽  
Lesion Load ◽  
Normal Appearing White Matter ◽  
Relapsing Remitting ◽  
One Year ◽  
Diffusion Tensor Imaging Dti

Our objectives were to determine the reproducibility of diffusion tensor imaging (DTI) in volunteers and to evaluate the ability of the method to monitor longitudinal changes occurring in the normal-appearing white matter (NAWM) of patients with multiple sclerosis (MS). DTI was performed three-mo nthly for one year in seven MS patients: three relapsing-remitting (RRMS), three secondary progressive (SPMS) and one relapsing SP. They were selected with a limited cerebral lesion load. Seven age- and sex-matched controls also underwent monthly examinations for three months. Diffusivity and anisotropy were quantified over the segmented whole supratentorial white matter, with the indices of trace (Tr) and fractional anisotropy (FA). Results obtained in volunteers show the reproducibility of the method. Patients had higher trace and lower anisotropy than matched controls (P B-0.0001). O ver the follow-up, both Tr and FA indicated a recovery after the acute phase in RRMS and a progressive shift towards abnormal values in SPMS. A lthough this result is not statistically significant, it suggests that DTI is sensitive to microscopic changes occurring in tissue of normal appearance in conventional images and could be useful for monitoring the course of the disease, even though it was unable to clearly distinguish between the various physiopathological processes involved.

The cervical spinal cord in neuromyelitis optica patients: A comparative study with multiple sclerosis using diffusion tensor imaging

2012 ◽  
Vol 81 (10) ◽  
pp. 2697-2701 ◽  
Author(s):  
Fernanda Miraldi Clemente Pessôa ◽  
Fernanda Cristina Rueda Lopes ◽  
João Victor Altamiro Costa ◽  
Soniza Vieira Alves Leon ◽  
Romeu Côrtes Domingues ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Spinal Cord ◽  
Diffusion Tensor Imaging ◽  
Comparative Study ◽  
Neuromyelitis Optica ◽  
Diffusion Tensor ◽  
Cervical Spinal Cord

scholarly journals Diffusion tensor imaging tractography reveals altered fornix in all diagnostic subtypes of multiple sclerosis

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Diana Valdés Cabrera ◽  
Robert Stobbe ◽  
Penelope Smyth ◽  
Fabrizio Giuliani ◽  
Derek Emery ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Diffusion Tensor Imaging ◽  
Diffusion Tensor ◽  
Diffusion Tensor Imaging Tractography
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