scholarly journals PROGNOSTIC VALUE OF THE EXPRESSION OF ENDOGENOUS HYPOXIA ASSOCIATED PROTEINS HYPOXIA INDUCIBLE FACTOR-1 ALPHA (HIF-1Α) AND CARBONIC ANHYDRASE ISOFORM 9 (CAIX) EXPRESSIONS IN BREAST CARCINOMA.

2018 ◽  
Vol 6 (2) ◽  
pp. 950-969
Author(s):  
OlaA Harb ◽  
◽  
Ibtesam Elhasadi ◽  
AmalMA Adim ◽  
WardaM Said ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Carbonic Anhydrase ◽  
Prognostic Value ◽  
Hypoxia Inducible Factor ◽  
Hypoxia Inducible Factor 1 ◽  
Associated Proteins

DEC1 (STRA13) protein expression relates to hypoxia- inducible factor 1-alpha and carbonic anhydrase-9 overexpression in non-small cell lung cancer

2003 ◽  
Vol 200 (2) ◽  
pp. 222-228 ◽  
Author(s):  
Alexandra Giatromanolaki ◽  
Michael I Koukourakis ◽  
Efthimios Sivridis ◽  
Helen Turley ◽  
Charles C Wykoff ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Carbonic Anhydrase ◽  
Protein Expression ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Hypoxia Inducible Factor ◽  
Small Cell ◽  
Small Cell Lung ◽  
Hypoxia Inducible Factor 1 ◽  
Carbonic Anhydrase 9

scholarly journals Carbonic Anhydrase Inhibitors Targeting Metabolism and Tumor Microenvironment

Metabolites ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 412 ◽  
Author(s):  
Andrea Angeli ◽  
Fabrizio Carta ◽  
Alessio Nocentini ◽  
Jean-Yves Winum ◽  
Raivis Zalubovskis ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Carbonic Anhydrase ◽  
Drug Targets ◽  
Ph Regulation ◽  
Hypoxia Inducible Factor ◽  
Lead Compounds ◽  
Hypoxia Inducible Factor 1 ◽  
Ca Ix ◽  
Activation Of Transcription ◽  
Hif Pathway

The tumor microenvironment is crucial for the growth of cancer cells, triggering particular biochemical and physiological changes, which frequently influence the outcome of anticancer therapies. The biochemical rationale behind many of these phenomena resides in the activation of transcription factors such as hypoxia-inducible factor 1 and 2 (HIF-1/2). In turn, the HIF pathway activates a number of genes including those involved in glucose metabolism, angiogenesis, and pH regulation. Several carbonic anhydrase (CA, EC 4.2.1.1) isoforms, such as CA IX and XII, actively participate in these processes and were validated as antitumor/antimetastatic drug targets. Here, we review the field of CA inhibitors (CAIs), which selectively inhibit the cancer-associated CA isoforms. Particular focus was on the identification of lead compounds and various inhibitor classes, and the measurement of CA inhibitory on-/off-target effects. In addition, the preclinical data that resulted in the identification of SLC-0111, a sulfonamide in Phase Ib/II clinical trials for the treatment of hypoxic, advanced solid tumors, are detailed.

Carbonic anhydrase IX and hypoxia-inducible factor 1 attenuate cardiac dysfunction after myocardial infarction

2021 ◽  
Author(s):  
Mariela Beatriz Nolly ◽  
Lorena Alejandra Vargas ◽  
María Verónica Correa ◽  
Juan Manuel Lofeudo ◽  
Andrés Oscar Pinilla ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Carbonic Anhydrase ◽  
Cardiac Dysfunction ◽  
Hypoxia Inducible Factor ◽  
Carbonic Anhydrase Ix ◽  
Hypoxia Inducible Factor 1

scholarly journals Levels of hypoxia-inducible factor-1? independently predict prognosis in patients with lymph node negative breast carcinoma

Cancer ◽  
2003 ◽  
Vol 97 (6) ◽  
pp. 1573-1581 ◽  
Author(s):  
Reinhard Bos ◽  
Petra van der Groep ◽  
Astrid E. Greijer ◽  
Avi Shvarts ◽  
Sybren Meijer ◽  
...  
Keyword(s):  
Lymph Node ◽  
Breast Carcinoma ◽  
Hypoxia Inducible Factor ◽  
Node Negative ◽  
Hypoxia Inducible Factor 1

scholarly journals Prognostic value of hypoxia-inducible factor-1 alpha and prolyl 4-hydroxylase beta polypeptide overexpression in gastric cancer

2018 ◽  
Vol 24 (22) ◽  
pp. 2381-2391 ◽  
Author(s):  
Jun Zhang ◽  
Yue Wu ◽  
Yu-Hang Lin ◽  
Shuai Guo ◽  
Pei-Fang Ning ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Prognostic Value ◽  
Hypoxia Inducible Factor ◽  
Hypoxia Inducible Factor 1
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