scholarly journals EVALUATION OF POLYMORPHONUCLEAR LEUCOCYTE ELASTASE LEVEL AS AN EARLY DIAGNOSTIC INDICATOR IN NEONATAL SEPSIS.

2016 ◽  
Vol 4 (10) ◽  
pp. 1596-1603
Author(s):  
FaragMohammed Zalat ◽  
◽  
IsmailAbouEl-ela Ramadan ◽  
AnasAbdel-rhman Yousef ◽  
EffatHussein Assar ◽  
...  
Keyword(s):  
Neonatal Sepsis ◽  
Polymorphonuclear Leucocyte ◽  
Leucocyte Elastase ◽  
Elastase Level ◽  
Diagnostic Indicator ◽  
Early Diagnostic

scholarly journals A New Marker for Early Diagnosis in Neonatal Sepsis: Polymorphonuclear Leucocyte Elastase Levels

2013 ◽  
Vol 35 (2) ◽  
pp. 46-51
Author(s):  
Muge Ozay Payasli ◽  
Ayse Ayaz Ozkul ◽  
Selime Ayaz ◽  
Emel Ataoglu ◽  
Murat Elevli
Keyword(s):  
Early Diagnosis ◽  
Neonatal Sepsis ◽  
Polymorphonuclear Leucocyte ◽  
Leucocyte Elastase

The Promising Rule of Neutrophil CD64 As an Early Diagnostic and Prognostic Marker in Neonatal Sepsis

PEDIATRICS ◽  
2016 ◽  
Vol 137 (Supplement 3) ◽  
pp. 457A-457A
Author(s):  
Heba E. Ossman ◽  
Shreen A. El-Masry ◽  
Nour M. Abdel Aal ◽  
Amira M. Mokhtar
Keyword(s):  
Prognostic Marker ◽  
Neonatal Sepsis ◽  
Neutrophil Cd64 ◽  
Early Diagnostic

Assessment of the Use of PCR as an Early Diagnostic Indicator of Bovine Tuberculosis in Dairy Farms

2019 ◽  
Vol 09 (01) ◽  
Author(s):  
Antonia Mataragka ◽  
Virginia Fyntani ◽  
Kyriaki Sotirakoglou ◽  
Aristomenis Katsiolis ◽  
Chrysoula Dile ◽  
...  
Keyword(s):  
Bovine Tuberculosis ◽  
Dairy Farms ◽  
Diagnostic Indicator ◽  
Early Diagnostic

Central-peripheral temperature gradient: an early diagnostic sign of late-onset neonatal sepsis in very low birth weight infants

2012 ◽  
Vol 40 (5) ◽  
Author(s):  
José Luis Leante-Castellanos ◽  
José M. Lloreda-García ◽  
Ana García-González ◽  
Caridad Llopis-Baño ◽  
Carmen Fuentes-Gutiérrez ◽  
...  
Keyword(s):  
Birth Weight ◽  
Temperature Gradient ◽  
Low Birth Weight ◽  
Neonatal Sepsis ◽  
Very Low Birth Weight ◽  
Late Onset ◽  
Low Birth Weight Infants ◽  
Diagnostic Sign ◽  
Peripheral Temperature ◽  
Early Diagnostic

scholarly journals Statistical validity of interleukin-6 as a biomarker for the diagnosis of early-onset neonatal sepsis

2012 ◽  
Vol 3 (1) ◽  
pp. 5 ◽  
Author(s):  
Sriparna Basu ◽  
Shashikant Dewangan ◽  
Shampa Anupurva ◽  
Ashok Kumar
Keyword(s):  
Risk Factors ◽  
Blood Culture ◽  
Cord Blood ◽  
Interleukin 6 ◽  
Neonatal Sepsis ◽  
Early Onset ◽  
Diagnostic Marker ◽  
Statistical Validity ◽  
Sepsis Screening ◽  
Early Diagnostic

Use of empirical antibiotics in neonates with risk factors of early-onset neonatal sepsis (EOS) is a common practice. A laboratory parameter is needed to help in the accurate diagnosis of EOS to avoid unnecessary use of antibiotics. The aim of this prospective observational cohort study was to compare the statistical validity of cord blood interleukin-6 (IL-6) with conventional sepsis screening as an early diagnostic marker for EOS. Eighty-seven neonates with antenatal risk factors for sepsis were followed up for 72 h for the development of EOS. Cord blood was collected for measurement of IL-6 concentrations. Blood culture and conventional sepsis screening (total leukocyte count, absolute neutrophil count, C-reactive protein and micro-erythrocyte sedimentation rate) were sent for analysis soon after delivery. The study group comprised of symptomatic neonates with positive blood culture (n=36). An equal number of gestational-age matched asymptomatic neonates without risk factor of sepsis served as controls. Statistical validity of IL-6 was compared with sepsis screening parameters as the diagnostic marker for EOS. Gram negative organisms were the predominant cause of EOS. The most commonly isolated organism was <em>Acinetobacter baumanii</em>. The sensitivity and specificity of IL-6 with a cut-off value of 40.5 pg/mL and area under curve of 0.959 were 92.3 and 90.48%, respectively. In contrast, the sensitivity and specificity of different parameters of sepsis screening ranged from 37.5-68.75% and 47.95-57.35%, respectively. In conclusion, cord blood IL-6 can be used as a highly sensitive and specific early diagnostic marker of EOS at a cut-off concentration of 40.5 pg/mL.

A Comparison of Plasma Polymorphonuclear Leucocyte Elastase Levels in Obese and Lean Individuals

1998 ◽  
Vol 26 (5) ◽  
pp. 252-256 ◽  
Author(s):  
E Adeyemi ◽  
S Benedict ◽  
A Abdulle
Keyword(s):  
Immunosorbent Assay ◽  
Polymorphonuclear Leucocyte ◽  
The Body ◽  
Enzyme Linked Immunosorbent Assay ◽  
Healthy Controls ◽  
Elastase Activity ◽  
Tissue Remodelling ◽  
Leucocyte Elastase ◽  
Normal Controls

Increased release of polymorphonuclear leucocyte (PMNL) elastase, when the PMNLs are activated, can damage tissues in vivo. It was postulated that PMNL elastase might have a tissue-remodelling effect in the body and that obese individuals might have less PMNL elastase activity than lean individuals. To test this hypothesis, plasma PMNL elastase levels were determined in 70 obese individuals and 30 lean normal controls. The PMNL elastase levels (determined by enzyme-linked immunosorbent assay) in the obese group (median 36.2 ng/ml) did not differ significantly from those in the lean healthy controls (32.6 ng/ml; P = 0.5).

scholarly journals Procalcitonin as a diagnostic tool for bacterial neonatal sepsis

2015 ◽  
Vol 55 (5) ◽  
pp. 268
Author(s):  
Nely Nelly ◽  
Guslihan Dasa Tjipta ◽  
Hakimi Hakimi ◽  
Bugis Mardina Lubis
Keyword(s):  
Blood Culture ◽  
Diagnostic Tool ◽  
Neonatal Sepsis ◽  
Predictive Value ◽  
Gold Standard ◽  
Diagnostic Study ◽  
Bacterial Sepsis ◽  
Quick Method ◽  
Reactive Protein ◽  
Early Diagnostic

Background Bacterial sepsis is the main cause of morbidity and mortality in neonates. Early diagnosis and appropriate treatment can reduce the mortality rate. Blood culture is the gold standard for diagnosis of bacterial sepsis, but it requires 3-5 days for results. Since the disease may progress rapidly in neonates, a faster diagnostic test is needed. Measurement of procalcitonin levels may be a quick method to diagnose bacterial sepsis in neonates. Some studies found the sensitivity of procalcitonin to be between 92-100%. Objective To assess the use of procalcitonin as an early diagnostic tool for bacterial neonatal sepsis. Methods This diagnostic study was conducted from October 2011 to February 2012. Forty-three neonates in the Perinatology Unit at H. Adam Malik Hospital were suspected to have bacterial sepsis. They underwent routine blood counts, blood cultures, as well as C-reactive protein and procalcitonin measurements. Subjects were collected by consecutive sampling. The gold standard of sepsis was based on any microorganism found in blood culture. Results Of 43 neonates, 36 neonates had bacterial sepsis. We found that procalcitonin sensitivity was 100%, specificity 85.71%, positive predictive value 97.29% and negative predictive value 100%. The ROC curve showed a cut-off point of 0.929 (95%CI 0.713 to 0.953). Conclusion Procalcitonin is useful as an early diagnostic tool for bacterial neonatal sepsis.

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