scholarly journals Prospective Clinical Evaluation of Intra-Articular Injection of Tin-117m (117mSn) Radiosynoviorthesis Agent for Management of Naturally Occurring Elbow Osteoarthritis in Dogs: A Pilot Study

2021 ◽  
Vol Volume 12 ◽  
pp. 117-128
Author(s):  
Karanvir S Aulakh ◽  
Mandi J Lopez ◽  
Caleb Hudson ◽  
Lorrie Gaschen ◽  
Michelle Fabiani ◽  
...  
Keyword(s):  
Pilot Study ◽  
Clinical Evaluation ◽  
Naturally Occurring ◽  
Elbow Osteoarthritis

scholarly journals Sleep during naturally occurring respiratory infections: A pilot study

2019 ◽  
Vol 79 ◽  
pp. 236-243 ◽  
Author(s):  
Julie Lasselin ◽  
Michael Ingre ◽  
Christina Regenbogen ◽  
Mats J. Olsson ◽  
Maria Garke ◽  
...  
Keyword(s):  
Pilot Study ◽  
Respiratory Infections ◽  
Naturally Occurring

EVALUATING CYCLIC PELVIC MOVEMENT IN PATIENTS WITH ACETABULAR LABRAL TEARS: A CASE-CONTROLLED PILOT STUDY

2014 ◽  
Vol 17 (03) ◽  
pp. 1450013
Author(s):  
Martin L. Tanaka ◽  
Allston J. Stubbs ◽  
David C. Holst ◽  
Benjamin L. Long
Keyword(s):  
Pilot Study ◽  
Physical Examination ◽  
Clinical Evaluation ◽  
Bilateral Symmetry ◽  
Radiographic Imaging ◽  
Common Cause ◽  
Specific Diagnosis ◽  
Labral Tears ◽  
Pelvic Movement ◽  
Examination Techniques

Acetabular labral tears are a common cause of hip pain, but specific diagnosis can be difficult due to limitations in current physical examination techniques and radiographic imaging. Pelvic dynamics were captured in 18 participants (10 labral tear patients) who performed single leg squats and stance exercises. Comparisons were made between the pathologic and non-pathologic legs of patients and between patients and controls. The analysis of bilateral symmetry showed significant differences in most parameters implying unique patient compensatory dynamics. Bilateral symmetry was found to be significant in detecting differences in movement patterns and may become a useful tool for clinical evaluation.

Clinical Evaluation of Efficacy and Tolerability of HMC05 in Healthy Subjects with Normal and High-Normal Blood Pressure: A Pilot Study

Planta Medica ◽  
2010 ◽  
Vol 77 (03) ◽  
pp. 221-225
Author(s):  
Hae Lee ◽  
Mi-sun Lim ◽  
Sook Seong ◽  
Jeonghyeon Park ◽  
Joomi Lee ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Pilot Study ◽  
Clinical Evaluation ◽  
Healthy Subjects ◽  
Normal Blood ◽  
Normal Blood Pressure

scholarly journals Production and clinical evaluation of breast lesion skin markers for automated three-dimensional ultrasonography of the breast: a pilot study

2020 ◽  
Vol 30 (6) ◽  
pp. 3356-3362
Author(s):  
Leon de Jong ◽  
Marcel K. Welleweerd ◽  
Jan C.M. van Zelst ◽  
Francoise J. Siepel ◽  
Stefano Stramigioli ◽  
...  
Keyword(s):  
Pilot Study ◽  
Clinical Evaluation ◽  
Breast Lesion ◽  
Three Dimensional ◽  
Lesion Skin

Evaluation of Intravenously Delivered Allogeneic Mesenchymal Stem Cells for Treatment of Elbow Osteoarthritis in Dogs: A Pilot Study

2019 ◽  
Vol 32 (03) ◽  
pp. 173-181 ◽  
Author(s):  
Anastasia Olsen ◽  
Valerie Johnson ◽  
Tracy Webb ◽  
Kelly Santangelo ◽  
Steven Dow ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Synovial Fluid ◽  
Outcome Measures ◽  
Post Treatment ◽  
Joint Fluid ◽  
Clinical Effects ◽  
Vertical Force ◽  
Naturally Occurring ◽  
Elbow Osteoarthritis

Objectives The aim of this study was to evaluate the safety and collect pilot data measuring clinical effects of intravenously administered, adipose-derived, culture-expanded, allogeneic mesenchymal stem cells in dogs with elbow osteoarthritis. Materials and Methods Dogs (n = 13) with naturally occurring elbow osteoarthritis received three intravenous doses of allogeneic canine mesenchymal stem cells via an open-label clinical trial. Primary outcome measures collected over a 6-month study period included objective gait analysis, accelerometry, owner questionnaires and joint fluid analysis. Results No acute adverse events were observed following repeated intravenous treatment with allogeneic mesenchymal stem cells. A significant improvement in mean client-specific outcome measure (CSOM) activity score and CSOM behaviour score was observed when pre-treatment values were compared with post-treatment values (day >28). In contrast, mean peak vertical force significantly decreased from baseline to post-treatment (>day 28). Weekly activity counts did not show a significant difference between baseline to post-treatment time points. Synovial fluid biomarkers did not change during treatment, and labelled mesenchymal stem cells were rarely detected in synovial fluid samples collected after mesenchymal stem cell administration. Clinical Significance For dogs with naturally occurring elbow osteoarthritis, intravenous administration of mesenchymal stem cells was clinically well tolerated. While some subjective outcome measures showed significant improvements, objective outcome measures did not confirm similar changes. Further research is needed before intravenous mesenchymal stem cells can be recommended as a treatment for elbow osteoarthritis in dogs.

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