scholarly journals N-terminal fragment of probrain natriuretic peptide is associated with diabetes microvascular complications in type 2 diabetes

2014 ◽  
pp. 585 ◽  
Author(s):  
Kumiko Hamano ◽  
Jun Suzuki ◽  
Ikue Nakadaira ◽  
Megumi Gonai
Keyword(s):  
Type 2 Diabetes ◽  
Natriuretic Peptide ◽  
Microvascular Complications ◽  
Terminal Fragment

scholarly journals A. Diagnostic and prognostic value of detection of the N-terminal fragment of brain natriuretic peptide in type 2 diabetes mellitus

2017 ◽  
Vol 95 (6) ◽  
pp. 553-557
Author(s):  
A. F. Verbovoy ◽  
Natal’ya A. Barabanova
Keyword(s):  
Diabetes Mellitus ◽  
Heart Failure ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Blood Glucose ◽  
Chronic Heart Failure ◽  
Brain Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Terminal Fragment

Detction of chronic heart failure at the stage of reversible changes can prevent the development of cardiovascular complications, reduce morbidity and mortality in patients with type 2 diabetes mellitus. The aim of our study was to explore the level of N-terminal fragment of pro-brain natriuretic peptide (NT-proBNP) and to evaluate the possibility of using this marker in diagnostics of chronic heart failure in patients with type 2 diabetes. The study included 60 patients with type 2 diabetes and concomitant chronic heart failure. All patients underwent echocardiography, blood glucose and glycated hemoglobin, creatinine, and NT-proBNP measurement. All patients with diabetes mellitus were shown to have elevated NT-proBNP levels in comparison with the control group. We established negative correlation of this parameter with the left ventricular ejection fraction and inverse correlation between NT-proBNP and blood glucose. The study confirmed the value of NT-proBNP measurement for diagnostics of CHF but demonstrated low specificity of this test for the assessment of severity (functional class) of CHF in patients with type 2 diabetes.

B-type natriuretic peptide: a biomarker of cardiovascular risk in type 2 diabetes.

2018 ◽  
Author(s):  
Ibtissem Oueslati ◽  
Nadia Khessairi ◽  
Emna Talbi ◽  
Meriem Yazidi ◽  
Fatma Chaker ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cardiovascular Risk ◽  
Natriuretic Peptide

563-P: Differentially Expressed Plasma miRNAs Are Closely Associated with the Presence of Microvascular Complications in Type 2 Diabetes: The 1000 Qatar-Omics Study Cohort

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 563-P
Author(s):  
AMMIRA S. AKIL ◽  
SUJITHA SUBASH PADMAJEYA ◽  
LAILA A. JERMAN ◽  
ALYA AL-KURBI ◽  
AMAL M. HUSSEIN ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Microvascular Complications ◽  
Differentially Expressed ◽  
Study Cohort ◽  
Plasma Mirnas

2-OR: Impact of N Terminal Pro B-Type Natriuretic Peptide and High Sensitivity Cardiac Troponin on the Prediction of Death and Cardiovascular Events in High-Risk Patients with Type 2 Diabetes

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 2-OR
Author(s):  
MARCUS V.B. MALACHIAS ◽  
PARDEEP JHUND ◽  
BRIAN CLAGGETT ◽  
MAGNUS O. WIJKMAN ◽  
RHONDA BENTLEY-LEWIS ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
High Risk ◽  
Natriuretic Peptide ◽  
Cardiac Troponin ◽  
Cardiovascular Events ◽  
High Sensitivity ◽  
High Risk Patients ◽  
Risk Patients

scholarly journals Impact of type 2 diabetes and microvascular complications on mortality and cardiovascular outcomes in a multiethnic Asian population

2021 ◽  
Vol 9 (1) ◽  
pp. e001413
Author(s):  
Jonathan Yap ◽  
Kamalesh Anbalakan ◽  
Wan Ting Tay ◽  
Daniel Ting ◽  
Carol Yim Cheung ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
Glycemic Control ◽  
Microvascular Complications ◽  
Population Based ◽  
Cardiovascular Outcomes ◽  
Microvascular Complication ◽  
The Impact ◽  
Hba1c Levels

IntroductionDiabetes mellitus is a growing public health epidemic in Asia. We examined the impact of type 2 diabetes, glycemic control and microvascular complications on mortality and cardiovascular outcomes in a multiethnic population-based cohort of Asians without prior cardiovascular disease.Research design and methodsThis was a prospective population-based cohort study in Singapore comprising participants from the three major Asian ethnic groups: Chinese, Malays and Indians, with baseline examination in 2004–2011. Participants with type 1 diabetes and those with cardiovascular disease at baseline were excluded. Type 2 diabetes, Hemoglobin A1c (HbA1c) levels and presence of microvascular complications (diabetic retinopathy and nephropathy) were defined at baseline. The primary outcome was all-cause mortality and major adverse cardiovascular events (MACEs), defined as a composite of cardiovascular mortality, myocardial infarction, stroke and revascularization, collected using a national registry.ResultsA total of 8541 subjects were included, of which 1890 had type 2 diabetes at baseline. Subjects were followed for a median of 6.4 (IQR 4.8–8.8) years. Diabetes was a significant predictor of mortality (adjusted HR 1.74, 95% CI 1.45 to 2.08, p<0.001) and MACE (adjusted HR 1.64, 95% CI 1.39 to 1.93, p<0.001). In those with diabetes, higher HbA1c levels were associated with increased MACE rates (adjusted HR (per 1% increase) 1.18, 95% CI 1.11 to 1.26, p<0.001) but not mortality (p=0.115). Subjects with two microvascular complications had significantly higher mortality and MACE compared with those with only either microvascular complication (adjusted p<0.05) and no microvascular complication (adjusted p<0.05).ConclusionDiabetes is a significant predictor of mortality and cardiovascular morbidity in Asian patients without prior cardiovascular disease. Among patients with type 2 diabetes, poorer glycemic control was associated with increased MACE but not mortality rates. Greater burden of microvascular complications identified a subset of patients with poorer outcomes.

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