scholarly journals Pathogenesis of coronary artery disease: focus on genetic risk factors and identification of genetic variants

2014 ◽  
pp. 15 ◽  
Author(s):  
Roberto Elosua ◽  
Sergi Sayols-Baixeras ◽  
Carla Lluís-Ganella ◽  
Gavin Lucas
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Genetic Variants ◽  
Genetic Risk ◽  
Genetic Risk Factors ◽  
Artery Disease ◽  
Disease Focus

Personalized management of coronary artery disease

ESC CardioMed ◽  
2018 ◽  
pp. 2989-2991
Author(s):  
Thorsten Kessler ◽  
Heribert Schunkert
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Genetic Risk ◽  
Coronary Atherosclerosis ◽  
Treatment Strategies ◽  
Integrated Approach ◽  
Genetic Risk Factors ◽  
Research Field ◽  
Artery Disease

Coronary artery disease and myocardial infarction are main causes of morbidity and mortality. In the past decades, several modifiable and non-modifiable risk factors underlying the disease have been identified. Recently, genome-wide association studies and next generation sequencing led to the discovery of genetic risk factors. Knowledge of these genetic risk factors has been shown to help to understand the pathophysiology of coronary atherosclerosis. Their knowledge might also be useful in risk prediction and diagnostics. Ultimately, an integrated approach using genetic information and novel imaging technologies should improve treatment strategies towards a personalized medicine. Here, we want to summarize recent findings in this research field and provide insight how these developments could be used to improve prevention and treatment of coronary atherosclerosis and its sequelae.

Prevalence of genetic risk factors for coronary artery disease in Corsica island (France)

2005 ◽  
Vol 79 (3) ◽  
pp. 210-213 ◽  
Author(s):  
A. Falchi ◽  
L. Giovannoni ◽  
I.S. Piras ◽  
C.M. Calo ◽  
P. Moral ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Genetic Risk ◽  
Genetic Risk Factors ◽  
Artery Disease

scholarly journals Validation of eight genetic risk factors in East Asian populations replicated the association of BRAP with coronary artery disease

2009 ◽  
Vol 54 (11) ◽  
pp. 642-646 ◽  
Author(s):  
Kunihiko Hinohara ◽  
Hitoshi Ohtani ◽  
Toshiaki Nakajima ◽  
Taishi Sasaoka ◽  
Motoji Sawabe ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Genetic Risk ◽  
East Asian ◽  
Genetic Risk Factors ◽  
Asian Populations ◽  
Artery Disease

scholarly journals Genetic risk factors for coronary artery disease

1998 ◽  
Vol 26 (1) ◽  
pp. 9-15
Author(s):  
Mitsuru MURATA ◽  
Koichi KAWANO ◽  
Yumiko MATSUBARA ◽  
Takeru ZAMA ◽  
Nobuo AOKI ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Genetic Risk ◽  
Genetic Risk Factors ◽  
Artery Disease

scholarly journals New genetic risk factors for coronary artery disease

1996 ◽  
Vol 27 (2) ◽  
pp. 243
Author(s):  
Marisa Serrato ◽  
Qun-Tao Yu ◽  
Faye Safavi ◽  
Robert Roberts ◽  
Ali J. Marian
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Genetic Risk ◽  
Genetic Risk Factors ◽  
Artery Disease

scholarly journals Genetic Variants and Haplotypes in OPG Gene Are Associated with Premature Coronary Artery Disease and Traditional Cardiovascular Risk Factors in Mexican Population: The GEA Study

2020 ◽  
Vol 39 (11) ◽  
pp. 2085-2094
Author(s):  
Nonanzit Pérez-Hernández ◽  
Rosalinda Posadas-Sánchez ◽  
Gilberto Vargas-Alarcón ◽  
Benny Giovanni Cazarín-Santos ◽  
Antonio Miranda-Duarte ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Cardiovascular Risk ◽  
Coronary Artery ◽  
Cardiovascular Risk Factors ◽  
Genetic Variants ◽  
Mexican Population ◽  
Premature Coronary Artery Disease ◽  
Artery Disease

P4455The controversial role of genetics behind premature CAD: a plausible excuse for the young?

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
J Sousa ◽  
M Mendonca ◽  
A Pereira ◽  
F Mendonca ◽  
M Neto ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Risk Score ◽  
Genetic Risk ◽  
Genetic Risk Score ◽  
Young Patients ◽  
Premature Cad ◽  
Artery Disease ◽  
Group B

Abstract Introduction The complex interaction between genes and environmental factors contribute to individual-level risk of coronary artery disease (CAD), often resulting in premature CAD. The role for genetic risk scores in premature CAD is still controversial. Objective To evaluate the importance of conventional risk factors and of a genetic risk score in younger and older patients with coronary artery disease Methods From a group of 1619 pts with angiographic documented CAD from the GENEMACOR study, we selected 1276 pts admitted for ACS and analysed them in 2 groups (group A: ≤50 years, n=491 pts, 87.2% male, mean age 44±4.9 and group B: >50 years, n=785 pts, 75.2% male, mean age 57±4.2). Univariate analysis was used to characterize the traits of each group and we used ROC curves and respective AUCs to evaluate the power of genetics in the prediction of CAD, through a Genetic Risk Score (GRS). Results 99.3% of the young patients had at least one modifiable risk factor, 18.4% had 2 modifiable risk factors and 75.2% had 3 or more modifiable risk factors. The pattern of risk factors contributing to CAD were different among groups: family history (A: 27.5%, B: 21.4%, p=0.015) and smoking habits (A: 64.8%, B: 42.9%, p<0.001) were more frequent among patients under 50, and traditional age-linked factors like hypertension (A: 58%, B: 75.7%, p<0.001), diabetes (A: 21.6%, B: 38.6%, p<0.001) were more common in the older group. Acute ST-elevation myocardial infarction was more frequent among the young (A: 55.4%, B: 47.4%, p=0.006), as non-ST clinical presentation was higher among elder patients. Regarding angiographic presentation, single vessel CAD was higher in group A (A: 50.3%, B: 40.9%, p<0.001), while multivessel diasease was higher in group B (A: 33.3%, B: 53.9%, p<0.001). At a mean follow-up of 5 years, older patients had a worst prognosis, registering a higher rate of cardiovascular death (A: 4.1%, B: 8.6%, p=0.002) and higher MACE (A: 26.8%, B: 31%, p=0.128),. Adding the genetic risk score (GRS), we achieved only a slight improvement in the AUC for predicting CAD (0.796->0.805, p=0.0178 and 0.748->0.761, p=0.0007 in patients under and over 50, respectively). Conclusion Coronary artery disease is not all the same, as premature CAD shares a unique and specific pattern of risk factors, clinical presentation, angiographic severity and prognosis. Genetics should not be used as an excuse to justify premature CAD, as there is frequently more than one potentially reversible risk factor present even in young patients and the additive predictive value of GRS is modest.

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