scholarly journals Intraperitoneal Injection of Graphene Oxide Nanoparticle Accelerates Stem Cell Therapy Effects on Acute Kidney Injury

2020 ◽  
Vol Volume 13 ◽  
pp. 21-32 ◽  
Author(s):  
Tahereh Foroutan ◽  
Mohsen Nafar ◽  
Elaheh Motamedi
Keyword(s):  
Acute Kidney Injury ◽  
Graphene Oxide ◽  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Intraperitoneal Injection ◽  
Kidney Injury ◽  
Oxide Nanoparticle

scholarly journals Mesenchymal stem cell therapy in acute kidney injury (AKI): review and perspectives

2020 ◽  
Vol 66 (suppl 1) ◽  
pp. s45-s54 ◽  
Author(s):  
Christian Sávio-Silva ◽  
Poliana Evelyn Soinski-Sousa ◽  
Maria Theresa A Balby-Rocha ◽  
Ádyna de Oliveira Lira ◽  
Érika Bevilaqua Rangel
Keyword(s):  
Acute Kidney Injury ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Kidney Injury ◽  
Mesenchymal Stem Cell Therapy

scholarly journals Stem cell-based treatment of kidney diseases

2020 ◽  
Vol 245 (10) ◽  
pp. 902-910
Author(s):  
Binbin Pan ◽  
Guoping Fan
Keyword(s):  
Chronic Kidney Disease ◽  
Stem Cells ◽  
Acute Kidney Injury ◽  
Stem Cell ◽  
Kidney Disease ◽  
Cell Therapy ◽  
Kidney Diseases ◽  
Kidney Injury ◽  
Great Promise ◽  
Kidney Organoids

Kidney dysfunction, including chronic kidney disease and acute kidney injury, is a globally prevalent health problem. However, treatment regimens are still lacking, especially for conditions involving kidney fibrosis. Stem cells hold great promise in the treatment of chronic kidney disease and acute kidney injury, but success has been hampered by insufficient incorporation of the stem cells in the injured kidney. Thus, new approaches for the restoration of kidney function after acute or chronic injury have been explored. Recently, kidney organoids have emerged as a useful tool in the treatment of kidney diseases. In this review, we discuss the mechanisms and approaches of cell therapy in acute kidney injury and chronic kidney disease, including diabetic kidney disease and lupus nephritis. We also summarize the potential applications of kidney organoids in the treatment of kidney diseases. Impact statement Stem cells hold great promise in regenerative medicine. Pluripotent stem cells have been differentiated into kidney organoids to understand human kidney development and to dissect renal disease mechanisms. Meanwhile, recent studies have explored the treatment of kidney diseases using a variety of cells, including mesenchymal stem cells and renal derivatives. This mini-review discusses the diverse mechanisms underlying current renal disease treatment via stem cell therapy. We postulate that clinical applications of stem cell therapy for kidney diseases can be readily achieved in the near future.

scholarly journals Rationale of Mesenchymal Stem Cell Therapy in Kidney Injury

2014 ◽  
Vol 127 (1-4) ◽  
pp. 75-80 ◽  
Author(s):  
Susanne V. Fleig ◽  
Benjamin D. Humphreys
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Kidney Injury ◽  
Mesenchymal Stem Cell Therapy

scholarly journals The Anti-Inflammatory, Anti-Oxidative, and Anti-Apoptotic Benefits of Stem Cells in Acute Ischemic Kidney Injury

2019 ◽  
Vol 20 (14) ◽  
pp. 3529 ◽  
Author(s):  
Kuo-Hua Lee ◽  
Wei-Cheng Tseng ◽  
Chih-Yu Yang ◽  
Der-Cherng Tarng
Keyword(s):  
Oxidative Stress ◽  
Stem Cells ◽  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Kidney Injury ◽  
Tubular Cells ◽  
Renal Tubular Cells ◽  
Therapeutic Benefits ◽  
Anti Inflammatory

Ischemia-reperfusion injury (IRI) plays a significant role in the pathogenesis of acute kidney injury (AKI). The complicated interaction between injured tubular cells, activated endothelial cells, and the immune system leads to oxidative stress and systemic inflammation, thereby exacerbating the apoptosis of renal tubular cells and impeding the process of tissue repair. Stem cell therapy is an innovative approach to ameliorate IRI due to its antioxidative, immunomodulatory, and anti-apoptotic properties. Therefore, it is crucial to understand the biological effects and mechanisms of action of stem cell therapy in the context of acute ischemic AKI to improve its therapeutic benefits. The recent finding that treatment with conditioned medium (CM) derived from stem cells is likely an effective alternative to conventional stem cell transplantation increases the potential for future therapeutic uses of stem cell therapy. In this review, we discuss the recent findings regarding stem cell-mediated cytoprotection, with a focus on the anti-inflammatory effects via suppression of oxidative stress and uncompromised immune responses following AKI. Stem cell-derived CM represents a favorable approach to stem cell-based therapy and may serve as a potential therapeutic strategy against acute ischemic AKI.

Rationale of Mesenchymal Stem Cell Therapy in Kidney Injury

2013 ◽  
Vol 61 (2) ◽  
pp. 300-309 ◽  
Author(s):  
Vincenzo Cantaluppi ◽  
Luigi Biancone ◽  
Alessandro Quercia ◽  
Maria Chiara Deregibus ◽  
Giuseppe Segoloni ◽  
...  
Keyword(s):  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Kidney Injury ◽  
Mesenchymal Stem Cell Therapy

scholarly journals Lipocalin 2 enhances mesenchymal stem cell-based cell therapy in acute kidney injury rat model

2017 ◽  
Vol 70 (1) ◽  
pp. 103-117 ◽  
Author(s):  
Mehryar Habibi Roudkenar ◽  
Raheleh Halabian ◽  
Hossein Abdul Tehrani ◽  
Fatemeh Amiri ◽  
Ali Jahanian-Najafabadi ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Cell Therapy ◽  
Rat Model ◽  
Kidney Injury ◽  
Lipocalin 2

scholarly journals Cell Therapy Using Human Induced Pluripotent Stem Cell-Derived Renal Progenitors Ameliorates Acute Kidney Injury in Mice

2015 ◽  
Vol 4 (9) ◽  
pp. 980-992 ◽  
Author(s):  
Takafumi Toyohara ◽  
Shin-Ichi Mae ◽  
Shin-Ichi Sueta ◽  
Tatsuyuki Inoue ◽  
Yukiko Yamagishi ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Stem Cell ◽  
Cell Therapy ◽  
Pluripotent Stem Cell ◽  
Kidney Injury ◽  
Induced Pluripotent Stem Cell ◽  
Induced Pluripotent ◽  
Renal Progenitors
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