scholarly journals Pyrrolyl thiadiazoles as Mycobacterium tuberculosis inhibitors and their in silico analyses

2015 ◽  
pp. 1
Author(s):  
Shrinivas Joshi ◽  
Uttam More ◽  
Shailesh Sorathiya ◽  
Deepshikha Koli ◽  
Tejraj Aminabhavi
Keyword(s):  
Mycobacterium Tuberculosis ◽  
In Silico ◽  
In Silico Analyses

In-silico Analyses of Natural Products on Leishmania Enzyme Targets

2015 ◽  
Vol 15 (3) ◽  
pp. 253-269 ◽  
Author(s):  
L. Scotti ◽  
H. Ishiki ◽  
F.J.B. Mendonca ◽  
M.S. Silva ◽  
M.T. Scotti
Keyword(s):  
Natural Products ◽  
In Silico ◽  
In Silico Analyses

In vivo and in silico analyses of estrogenic potential of equine estrogens in medaka (Oryzias latipes)

2021 ◽  
Vol 767 ◽  
pp. 144379
Author(s):  
Hiroshi Ishibashi ◽  
Masaya Uchida ◽  
Masashi Hirano ◽  
Taka Hayashi ◽  
Ryoko Yamamoto ◽  
...  
Keyword(s):  
In Silico ◽  
Oryzias Latipes ◽  
Estrogenic Potential ◽  
Equine Estrogens ◽  
In Silico Analyses

scholarly journals How to Use Online Tools to Generate New Hypotheses for Mammary Gland Biology Research: A Case Study for Wnt7b

2021 ◽  
Author(s):  
Yorick Bernardus Cornelis van de Grift ◽  
Nika Heijmans ◽  
Renée van Amerongen
Keyword(s):  
Mammary Gland ◽  
In Silico ◽  
Online Tools ◽  
Mammary Gland Biology ◽  
User Friendly ◽  
In Silico Analyses ◽  
Biology Research ◽  
Selection Of

AbstractAn increasing number of ‘-omics’ datasets, generated by labs all across the world, are becoming available. They contain a wealth of data that are largely unexplored. Not every scientist, however, will have access to the required resources and expertise to analyze such data from scratch. Fortunately, a growing number of investigators is dedicating their time and effort to the development of user friendly, online applications that allow researchers to use and investigate these datasets. Here, we will illustrate the usefulness of such an approach. Using regulation of Wnt7b expression as an example, we will highlight a selection of accessible tools and resources that are available to researchers in the area of mammary gland biology. We show how they can be used for in silico analyses of gene regulatory mechanisms, resulting in new hypotheses and providing leads for experimental follow up. We also call out to the mammary gland community to join forces in a coordinated effort to generate and share additional tissue-specific ‘-omics’ datasets and thereby expand the in silico toolbox.

Arylquinolinecarboxamides: Synthesis, in vitro and in silico studies against Mycobacterium tuberculosis

2021 ◽  
Author(s):  
Fostino R. B. Bokosi ◽  
Richard M. Beteck ◽  
Audrey Jordaan ◽  
Ronnet Seldon ◽  
Digby F. Warner ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
In Silico ◽  
In Silico Studies

scholarly journals In Silico Analyses of Rice Thionin Genes and the Antimicrobial Activity of OsTHION15 Against Phytopathogens

2019 ◽  
Vol 109 (1) ◽  
pp. 27-35
Author(s):  
Krissana Boonpa ◽  
Suparuk Tantong ◽  
Kamonwan Weerawanich ◽  
Pawinee Panpetch ◽  
Onanong Pringsulaka ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Stress Responses ◽  
In Silico ◽  
Pathogenic Bacteria ◽  
Hyphal Growth ◽  
In Planta ◽  
Recombinant Peptide ◽  
Plant Disease Control ◽  
Helminthosporium Oryzae ◽  
In Silico Analyses

Thionins are a family of antimicrobial peptides. We performed in silico expression analyses of the 44 rice (Oryza sativa) thionins (OsTHIONs). Modulated expression levels of OsTHIONs under different treatments suggest their involvement in many processes, including biotic, abiotic, and nutritional stress responses, and in hormone signaling. OsTHION15 (LOC_Os06g32600) was selected for further characterization based on several in silico analyses. OsTHION15 in O. sativa subsp. indica ‘KDML 105’ was expressed in all of the tissues and organs examined, including germinating seed, leaves, and roots of seedlings and mature plants, and inflorescences. To investigate the antimicrobial activity of OsTHION15, we produced a recombinant peptide in Escherichia coli Rosetta-gami (DE3). The recombinant OsTHION15 exhibited inhibitory activities toward rice-pathogenic bacteria such as Xanthomonas oryzae pv. oryzae and Pectobacterium carotovorum pv. atroseptica, with minimum inhibitory concentrations of 112.6 and 14.1 µg ml−1, respectively. A significant hyphal growth inhibition was also observed toward Fusarium oxysporum f. sp. cubense and Helminthosporium oryzae. In addition, we demonstrated the in planta antibacterial activity of this peptide in Nicotiana benthamiana against X. campestris pv. glycines. These activities suggest the possible application of OsTHION15 in plant disease control.

scholarly journals Whole genome and in-silico analyses of G1P[8] rotavirus strains from pre- and post-vaccination periods in Rwanda

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Sebotsana Rasebotsa ◽  
Peter N. Mwangi ◽  
Milton T. Mogotsi ◽  
Saheed Sabiu ◽  
Nonkululeko B. Magagula ◽  
...  
Keyword(s):  
In Silico ◽  
Whole Genome ◽  
Post Vaccination ◽  
In Silico Analyses
Sign in / Sign up

Export Citation Format

Share Document