scholarly journals Cardiac function and hypertension in patients with obstructive sleep apnea

2014 ◽  
pp. 189
Author(s):  
Carolina Gonzaga ◽  
Adriana Bertolami ◽  
Celso Amodeo
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Cardiac Function ◽  
Obstructive Sleep

Effects of CPAP treatment on cardiac structure and function in individuals with obstructive sleep apnea and cardiovascular disease: a prospective 6-month randomised control trial

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
K Franke ◽  
K.A Loffler ◽  
S.J Nicholls ◽  
C.S Anderson ◽  
B.R Cowan ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Cardiac Function ◽  
Right Ventricular ◽  
Usual Care ◽  
Randomised Control Trial ◽  
Funding Source ◽  
Cpap Treatment ◽  
Obstructive Sleep

Abstract Background Obstructive sleep apnea (OSA) is associated with an increased risk of cardiovascular events. The influence of continuous positive airway pressure (CPAP) on cardiac function remains uncertain. Purpose To prospectively determine the effects of CPAP on cardiovascular function, as measured by cardiac magnetic resonance imaging (CMR) as a sub-study of the international SAVE trial (NCT00738179). Methods Participants with OSA and established cardiovascular disease were randomized to CPAP treatment plus usual cardiovascular care or Usual Care alone. Primary outcomes were defined as change in ventricular ejection fraction (EF) and stroke volume (SV) between baseline and 6-month follow-up both groups. Secondary outcomes included other ventricular parameters including volumes, mass, and strain, and atrial parameters. Results 140 participants were included; mean CPAP adherence in those allocated to receive the treatment was 4.31±2.45 hours per night. Most were male (91%) and had moderate-severe OSA with minimal daytime sleepiness. There were no significant differences in left or right ventricular EF between groups after 6 months of treatment. There was an 8.5 mL increase in LV SV (95% CI; [4.3–12.6], p<0.001) and a 7.7 mL increase in RV SV (95% CI; [3.4–12.0], p<0.001) in the CPAP group compared to Usual Care. CPAP also affected left and right ventricular EDV, RV strain, and atrial parameters. Conclusions In the first prospective CMR imaging study of patients with OSA and cardiovascular disease, CPAP treatment did not change EF after 6 months, but did have significant effects on other parameters of cardiac function. Funding Acknowledgement Type of funding source: Other. Main funding source(s): Respironics Foundation; Australian National Health and Medical Research; New Zealand Health Research Council

Decrease in ventricular stroke volume at apnea termination is independent of oxygen desaturation

1994 ◽  
Vol 77 (4) ◽  
pp. 1602-1608 ◽  
Author(s):  
E. Garpestad ◽  
J. A. Parker ◽  
H. Katayama ◽  
J. Lilly ◽  
T. Yasuda ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Continuous Positive Airway Pressure ◽  
Stroke Volume ◽  
Cardiac Function ◽  
Airway Pressure ◽  
Positive Airway Pressure ◽  
Auditory Signal ◽  
Ventricular Stroke Volume ◽  
Obstructive Sleep

Patients with obstructive sleep apnea experience nocturnal hemodynamic oscillations in association with repetitive respiratory events. Apnea termination (recovery) is accompanied by the nadir of arterial O2 saturation (SaO2), changes in intrathoracic pressure, and arousal from sleep. To investigate separately the contributions of hypoxemia and of arousal from sleep to changes in cardiac function, we continuously measured left ventricular stroke volume (LVSV) and mean arterial pressure (MAP) in eight subjects with severe obstructive sleep apnea (apnea-hypopnea index > 30 events/h associated with SaO2 < or = 82%) during two experimental conditions: 1) subjects slept without intervention for 1–2 h and then supplemental O2 was administered to maintain SaO2 > or = 90% (mean SaO2 nadir 92.7%) throughout the apnea-recovery cycle and 2) upper airway obstructions were abolished using nasal continuous positive airway pressure and subjects were aroused from sleep by an auditory signal. Recovery was associated with an increase in MAP and a decrease in LVSV both with and without supplemental O2. Arousal from sleep on nasal continuous positive airway pressure reproduced the postapneic elevation of MAP but not a decrease in cardiac function of the magnitude that occurred at apnea termination. We conclude that elevation of blood pressure and reduction of LVSV that occurred at apnea termination may be due to different physiological mechanisms.

Investigation of Cardiac Function in Children with Suspected Obstructive Sleep Apnea

2003 ◽  
Vol 32 (03) ◽  
pp. 151 ◽  
Author(s):  
Adrian L. James ◽  
Martin Runciman ◽  
Martin J. Burton ◽  
Andrew P. Freeland
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Cardiac Function ◽  
Obstructive Sleep

scholarly journals Sleepiness in Obstructive Sleep Apnea: A Harbinger of Impaired Cardiac Function?

SLEEP ◽  
2006 ◽  
Vol 29 (12) ◽  
pp. 1531-1536 ◽  
Author(s):  
Jong-Bae Choi ◽  
Richard Nelesen ◽  
José S. Loredo ◽  
Paul J. Mills ◽  
Sonia Ancoli-Israel ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Cardiac Function ◽  
Obstructive Sleep ◽  
Impaired Cardiac Function

scholarly journals Effect of Adenotonsillectomy on Cardiac Function in Children Age 5-13 Years With Obstructive Sleep Apnea

2020 ◽  
Author(s):  
Keren Armoni Domany ◽  
Guixia Huang ◽  
Md Monir Hossain ◽  
Christine L Schuler ◽  
Virend K. Somers ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Cardiac Function ◽  
Obstructive Sleep

scholarly journals Influence and Predicting Variables of Obstructive Sleep Apnea on Cardiac Function and Remodeling in Patients without Congestive Heart Failure

2014 ◽  
Vol 10 (01) ◽  
pp. 57-64 ◽  
Author(s):  
Yung-Lung Chen ◽  
Mao-Chang Su ◽  
Wen-Hao Liu ◽  
Chin-Chou Wang ◽  
Meng-Chih Lin ◽  
...  
Keyword(s):  
Heart Failure ◽  
Congestive Heart Failure ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Cardiac Function ◽  
Obstructive Sleep

Cardiac Function in Obstructive Sleep Apnea Patients following Uvulopalatopharyngoplasty

1992 ◽  
Vol 107 (3) ◽  
pp. 390-394 ◽  
Author(s):  
Yuval Zohar ◽  
Yoav P. Talmi ◽  
Haya Frenkel ◽  
Yehuda Finkelstein ◽  
Carlos Rudnicki ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Ejection Fraction ◽  
Cardiac Function ◽  
Left Ventricular ◽  
Ventricular Ejection ◽  
Treatment Modalities ◽  
Left Ventricular Ejection ◽  
Ventricular Ejection Fraction ◽  
Obstructive Sleep

Obstructive sleep apnea syndrome (OSAS) is associated with severe cardiac arrhythmias and conduction abnormalities. Cor pulmonale and right-sided heart failure may ensue. Uvulopalatopharyngoplasty (UPPP) is one of several treatment modalities suggested for OSAS. Tracheotomy and CPAP treatment in adult OSAS patients and adenotonsillectomy in children with OSAS were shown to lead to improvement in some cardiac parameters. Cardiac function was prospectively evaluated in 19 OSAS patients before and after UPPP. No significant changes after surgery were noted on electrocardiographic studies. Improvement in global and regional function of both ventricles was seen in 91% of the patients. A trend toward significant elevation in left ventricular ejection fraction and a statistically significant increase in right ventricular ejection fraction were observed (45% = 9% to 50% = 7% [p = 0.007]). Our results support performance of UPPP in selected OSAS patients for relief of potentially life-threatening cardiac pathologies

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