scholarly journals Toxoplasma gondii infection and neuropsychiatric disease: current insight

2015 ◽  
pp. 43 ◽  
Author(s):  
Dunja Hinze-Selch
Keyword(s):  
Toxoplasma Gondii ◽  
Neuropsychiatric Disease ◽  
Toxoplasma Gondii Infection

Analysis of the antibodies anti-Toxoplasma gondii by ELISA based on two diagnostic antigens: rSAG1 and rBAG1

2011 ◽  
Vol 56 (4) ◽  
Author(s):  
Min Liu ◽  
Tao Wang ◽  
Hua Li ◽  
Ju-Ying Li ◽  
Han Zhong ◽  
...  
Keyword(s):  
Toxoplasma Gondii ◽  
Immunosorbent Assay ◽  
Blood Donors ◽  
Enzyme Linked Immunosorbent Assay ◽  
Igg Antibody ◽  
Neuropsychiatric Disease ◽  
Increased Risk ◽  
Positive Rate ◽  
Toxoplasma Gondii Infection ◽  
Uncertain Etiology

AbstractSchizophrenia is a serious neuropsychiatric disease of uncertain etiology. Previous studies have demonstrated that antibodies to Toxoplasma gondii infection are associated with an increased risk of schizophrenia. The objective of this study was to analyze anti-T. gondii antibodies in 477 Chinese schizophrenia patients using an enzyme-linked immunosorbent assay (ELISA) based on recombinant surface antigen 1 (rSAG1), recombinant bradyzoite antigen 1 (rBAG1) and the soluble tachyzoite antigens (STAg) of T. gondii RH strain. Results showed that among the sero-positives (IgG and/or IgM) for T. gondii infection examined in schizophrenia patients, sero-positive samples for rSAG1, rBAG1 and STAg were 20.5% (98/477), 20.5% (98/477) and 23.5% (112/477) respectively, while compared to 210 blood donors, sero-positive (IgG and/or IgM) samples for these antigens (rSAG1, rBAG1 and STAg) were only 5.7% (12/210), 6.2% (13/210) and 5.7% (12/210), respectively. Furthermore, when IgG antibody reaction in the schizophrenia sera was compared with the rBAG1 and rSAG1, results demonstrated that beside the cases which can be detected by both rSAG1 and rBAG1, some sero-positive for T. gondii in schizophrenia sera can only be detected either by rSAG1 or rBAG1. This phenomenon was also observed in the detection of IgM with rSAG1 and rBAG1. 5.9% (28/477) of cases of schizophrenia which are positive for IgG or IgM by rSAG1 are negative for STAg, while 9.2% (44/477) of the schizophrenia cases which are positive for IgG or IgM by rBAG1 are negative for STAg. Although STAg can also be used to diagnose T. gondii infection from schizophrenia patients, it may not actually indicate the infection as some positive samples may be mistakenly considered to be negative. In conclusion, our results demonstrate that the sero-positive rate for T. gondii in the Chinese schizophrenia patients was higher than blood donors. More importantly, our results provide evidence that the combination of rSAG1 and rBAG1 antigens in the diagnosis of T. gondii infection could closely reflect the actual infection of this parasite in schizophrenia patients.

The management of acute Toxoplasma gondii infection during pregnancy – literature review

2018 ◽  
Vol 1 (19) ◽  
pp. 16
Author(s):  
Mihai Mitran ◽  
Octavia Velicu ◽  
Roberta Ciobanu ◽  
Diana-Elena Comandașu ◽  
Elvira Brătilă
Keyword(s):  
Toxoplasma Gondii ◽  
Literature Review ◽  
Toxoplasma Gondii Infection

The High Potency of Green Synthesized Copper Nanoparticles to Prevent the Toxoplasma gondii Infection in Mice

2021 ◽  
Author(s):  
Aishah E. Albalawi ◽  
Abdullah D. Alanazi ◽  
Mohamed S. Alyousif ◽  
Azadeh Sepahvand ◽  
Katrin Ebrahimi ◽  
...  
Keyword(s):  
Toxoplasma Gondii ◽  
Copper Nanoparticles ◽  
High Potency ◽  
Toxoplasma Gondii Infection

scholarly journals Protective efficacy by a novel multi-epitope vaccine, including MIC3, ROP8, and SAG1, against acute Toxoplasma gondii infection in BALB/c mice

2021 ◽  
Vol 153 ◽  
pp. 104764
Author(s):  
Samira Dodangeh ◽  
Mahdi Fasihi-Ramandi ◽  
Ahmad Daryani ◽  
Reza Valadan ◽  
Hossein Asgarian-Omran ◽  
...  
Keyword(s):  
Toxoplasma Gondii ◽  
Protective Efficacy ◽  
Epitope Vaccine ◽  
Toxoplasma Gondii Infection

scholarly journals Toxoplasma gondii infection in domestic and wild felids as public health concerns: a systematic review and meta-analysis

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Kareem Hatam-Nahavandi ◽  
Rafael Calero-Bernal ◽  
Mohammad Taghi Rahimi ◽  
Abdol Sattar Pagheh ◽  
Mehdi Zarean ◽  
...  
Keyword(s):  
Public Health ◽  
Toxoplasma Gondii ◽  
Meta Analysis ◽  
Domestic Cats ◽  
Potential Threat ◽  
Pooled Prevalence ◽  
Wild Felids ◽  
Global Status ◽  
The One ◽  
Toxoplasma Gondii Infection

AbstractFelidae as definitive hosts for Toxoplasma gondii play a major role in transmission to all warm-blooded animals trough oocysts dissemination. Therefore the current comprehensive study was performed to determine the global status of T. gondii infection in domestic and wild felids aiming to provide comprehensive data of interest for further intervention approaching the One Health perspective. Different databases were searched by utilizing particular key words for publications related to T. gondii infecting domestic and wild feline host species, worldwide, from 1970 to 2020. The review of 337 reports showed that the seroprevalence of T. gondii in domestic cats and wild felids was estimated in 37.5% (95% CI 34.7–40.3) (I2 = 98.3%, P < 0.001) and 64% (95% CI 60–67.9) (I2 = 88%, P < 0.0001), respectively. The global pooled prevalence of oocysts in the fecal examined specimens from domestic cats was estimated in 2.6% (95% CI 1.9–3.3) (I2 = 96.1%, P < 0.0001), and that in fecal samples from wild felids was estimated in 2.4% (95% CI 1.1–4.2) (I2 = 86.4%, P < 0.0001). In addition, from 13,252 examined soil samples in 14 reviewed studies, the pooled occurrence of T. gondii oocysts was determined in 16.2% (95% CI 7.66–27.03%). The observed high rates of anti-T. gondii antibodies seroprevalence levels and oocyst excretion frequency in the felids, along with soil (environmental) contamination with oocysts may constitute a potential threat to animal and public health, and data will result of interest in further prophylaxis programs.

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