Management of scalp psoriasis: current perspectives

Introduction: Too many patients with moderate to severe psoriasis do not receive adequate treatment. This means a vast undersupply in the treatment of patients with psoriasis. Only biologics fulfill the whole range of the treatment of psoriasis – psoriasis does not affect only skin but the whole organism: It is a systemic disease! Between the biologics are evident differences concerning the effect. Discussion: Based on broad personal experience in the management of patients with moderate to severe psoriasis new data from clinical studies with ixekizumab are examined. This contains new data on long-term-efficacy of ixekizumab, effectiveness in special localizations (scalp psoriasis, nail psoriasis, palmoplantar psoriasis, genital psoriasis) as well as safely data and experience on patients switched to ixekizumab from other biologics. Personal clinical experience is based on >300 non-selected outpatients with moderate to severe psoriasis, >250 patients on biological therapies, > 50 patients with ixekizumab. Conclusions: Focusing on a relevant number of patients switched from secukinumab to ixekizumab due to first or secondary loss of efficacy significant differences between both IL-17A-inhibitors mainly in terms of efficacy and speed of therapeutic response are shown. Finally the correlation between PASI-90-/PASI-100 response and significant changes in DLQI are highlighted.

Download Full-text

Scalp Psoriasis: A Review of the Current Therapies and Case Report of the Successful Use of the Excimer Laser in Recalcitrant Disease

Psoriasis Forum ◽

10.1177/247553031016a00407 ◽

2010 ◽

Vol 16a (4) ◽

pp. 53-60

Author(s):

Bradley Glodny ◽

Carolin Penrose

Keyword(s):

Case Report ◽

Excimer Laser ◽

Scalp Psoriasis ◽

Current Therapies

Download Full-text

Efficacy and safety of 308‐nm excimer lamp in the treatment of scalp psoriasis: a retrospective study

Photodermatology Photoimmunology & Photomedicine ◽

10.1111/phpp.12448 ◽

2019 ◽

Vol 35 (3) ◽

pp. 172-177

Author(s):

Ploysyne Rattanakaemakorn ◽

Phanitchanat Phusuphitchayanan ◽

Kallapan Pakornphadungsit ◽

Kunlawat Thadanipon ◽

Poonkiat Suchonwanit

Keyword(s):

Retrospective Study ◽

Efficacy And Safety ◽

Excimer Lamp ◽

Scalp Psoriasis

Download Full-text

Characteristics of Pruritus in Various Clinical Variants of Psoriasis: Results of the Multinational, Multicenter, Cross-Sectional Study

Life ◽

10.3390/life11070623 ◽

2021 ◽

Vol 11 (7) ◽

pp. 623

Author(s):

Kamila Jaworecka ◽

Dominika Kwiatkowska ◽

Luiza Marek ◽

Funda Tamer ◽

Aleksandra Stefaniak ◽

...

Keyword(s):

Clinical Symptoms ◽

Cross Sectional Study ◽

Pustular Psoriasis ◽

Cross Sectional ◽

Large Plaque ◽

Scalp Psoriasis ◽

Generalized Pustular Psoriasis ◽

Itch Sensation ◽

Clinical Variants ◽

Subtype A

Psoriasis is a chronic, inflammatory skin disease present in about 3% of the world’s population. The clinical symptoms manifest diversely, therefore one can distinguish several subtypes of psoriasis. The majority of patients with psoriasis experience pruritus, which is an unpleasant sensation that decreases patients’ quality of life. The knowledge on pruritus in different subtypes of psoriasis is limited. We have performed a cross-sectional, prospective, and multicenter study to evaluate the relationship between clinical subtypes of psoriasis (large-plaque, nummular, guttate, palmoplantar, inverse, erythrodermic, palmoplantar pustular, generalized pustular psoriasis, and psoriasis of the scalp) and the prevalence, intensity, and clinical manifestation of itch. We introduced a questionnaire assessing various aspects of pruritus to a total of 254 patients. Out of these, 42 were excluded. Pruritus was present in 92.9% of the remaining patients and its prevalence did not depend on the clinical subtype. A correlation between the severity of psoriasis and the intensity of itch was explicitly noticeable in palmoplantar pustular psoriasis and scalp psoriasis (p < 0.05). The itch sensation was individual and differed among subtypes of psoriasis. In conclusion, pruritus is a frequent phenomenon, and its presentation is different in various subtypes of psoriasis.

Download Full-text