scholarly journals Work Outcomes Among Patients with Light Chain (AL) Amyloidosis: Findings from Three Patient Cohorts

2021 ◽  
Vol Volume 12 ◽  
pp. 339-347
Author(s):  
Avery A Rizio ◽  
Kristen L McCausland ◽  
Michelle K White ◽  
Tiffany P Quock
Keyword(s):  
Light Chain ◽  
Work Outcomes ◽  
Al Amyloidosis

Two distinct mechanisms of neuropathy in immunoglobulin light chain (AL) amyloidosis

2021 ◽  
pp. 117305
Author(s):  
Haruki Koike ◽  
Naohiro Mouri ◽  
Yuki Fukami ◽  
Masahiro Iijima ◽  
Koji Matsuo ◽  
...  
Keyword(s):  
Light Chain ◽  
Al Amyloidosis ◽  
Immunoglobulin Light Chain

scholarly journals Clarification on the definition of complete haematologic response in light-chain (AL) amyloidosis

Amyloid ◽  
2021 ◽  
pp. 1-2
Author(s):  
Giovanni Palladini ◽  
Stefan O. Schönland ◽  
Vaishali Sanchorawala ◽  
Shaji Kumar ◽  
Ashutosh Wechalekar ◽  
...  
Keyword(s):  
Light Chain ◽  
Al Amyloidosis ◽  
Definition Of

Light chain multiple myeloma with cutaneous AL amyloidosis

2008 ◽  
Vol 6 (9) ◽  
pp. 744-745 ◽  
Author(s):  
Maria Rita Becker ◽  
Rainer Rompel ◽  
Jörg Plum ◽  
Timo Gaiser
Keyword(s):  
Multiple Myeloma ◽  
Light Chain ◽  
Al Amyloidosis

Autologous Stem Cell Transplantation and Primary Systemic Light Chain (AL) Amyloidosis

2015 ◽  
Vol 15 ◽  
pp. e173
Author(s):  
S.K. Toprak ◽  
P. Ataca ◽  
E. Atilla ◽  
S.C. Bozdag ◽  
M.K. Yuksel ◽  
...  
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Autologous Stem Cell Transplantation ◽  
Light Chain ◽  
Al Amyloidosis

scholarly journals Second stem cell transplantation for relapsed refractory light chain (AL) amyloidosis

2021 ◽  
Author(s):  
Eli Muchtar ◽  
Angela Dispenzieri ◽  
Shaji K. Kumar ◽  
Martha Q. Lacy ◽  
Francis K. Buadi ◽  
...  
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Light Chain ◽  
Al Amyloidosis

scholarly journals Minimal residual disease negativity by next-generation flow cytometry is associated with improved organ response in AL amyloidosis

2021 ◽  
Vol 11 (2) ◽  
Author(s):  
Giovanni Palladini ◽  
Bruno Paiva ◽  
Ashutosh Wechalekar ◽  
Margherita Massa ◽  
Paolo Milani ◽  
...  
Keyword(s):  
Minimal Residual Disease ◽  
Organ Dysfunction ◽  
Light Chain ◽  
Residual Disease ◽  
Cell Clone ◽  
Cardiac Response ◽  
Al Amyloidosis ◽  
Next Generation ◽  
Organ Response ◽  
Minimal Residual

AbstractLight chain (AL) amyloidosis is caused by a small B-cell clone producing light chains that form amyloid deposits and cause organ dysfunction. Chemotherapy aims at suppressing the production of the toxic light chain (LC) and restore organ function. However, even complete hematologic response (CR), defined as negative serum and urine immunofixation and normalized free LC ratio, does not always translate into organ response. Next-generation flow (NGF) cytometry is used to detect minimal residual disease (MRD) in multiple myeloma. We evaluated MRD by NGF in 92 AL amyloidosis patients in CR. Fifty-four percent had persistent MRD (median 0.03% abnormal plasma cells). There were no differences in baseline clinical variables in patients with or without detectable MRD. Undetectable MRD was associated with higher rates of renal (90% vs 62%, p = 0.006) and cardiac response (95% vs 75%, p = 0.023). Hematologic progression was more frequent in MRD positive (0 vs 25% at 1 year, p = 0.001). Altogether, NGF can detect MRD in approximately half the AL amyloidosis patients in CR, and persistent MRD can explain persistent organ dysfunction. Thus, this study supports testing MRD in CR patients, especially if not accompanied by organ response. In case MRD persists, further treatment could be considered, carefully balancing residual organ damage, patient frailty, and possible toxicity.

scholarly journals Light Chain (AL) Amyloidosis: The Journey to Diagnosis

2017 ◽  
Vol 11 (2) ◽  
pp. 207-216 ◽  
Author(s):  
Kristen L. McCausland ◽  
Michelle K. White ◽  
Spencer D. Guthrie ◽  
Tiffany Quock ◽  
Muriel Finkel ◽  
...  
Keyword(s):  
Light Chain ◽  
Al Amyloidosis
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