scholarly journals Pilot study investigating the utility of a specialized online symptom management program for individuals with myalgic encephalomyelitis/chronic fatigue syndrome as compared to an online meditation program

2014 ◽  
pp. 213 ◽  
Author(s):  
Megan Arroll ◽  
Elizabeth Attree ◽  
Clare Marshall ◽  
Christine Dancey
Keyword(s):  
Pilot Study ◽  
Chronic Fatigue Syndrome ◽  
Symptom Management ◽  
Chronic Fatigue ◽  
Management Program ◽  
Myalgic Encephalomyelitis ◽  
Fatigue Syndrome

scholarly journals Defining the prevalence and symptom burden of those with self-reported severe chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME): a two-phase community pilot study in the North East of England

BMJ Open ◽  
2018 ◽  
Vol 8 (9) ◽  
pp. e020775 ◽  
Author(s):  
Victoria Jane Strassheim ◽  
Madison Sunnquist ◽  
Leonard A Jason ◽  
Julia L Newton
Keyword(s):  
Pilot Study ◽  
Chronic Fatigue Syndrome ◽  
Symptom Burden ◽  
Chronic Fatigue ◽  
Myalgic Encephalomyelitis ◽  
Phase 2 ◽  
Two Phase ◽  
Community Based Research ◽  
North East ◽  
Fatigue Syndrome

ObjectivesTo define the prevalence of severe chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) and its clinical characteristics in a geographically defined area of Northern England. To understand the feasibility of a community-based research study in the severely affected CFS/ME group.DesignA two-phase clinical cohort study to pilot a series of investigations in participants own homes.SettingParticipants were community living from the area defined by the Northern clinical network of the UK.ParticipantsAdults with either a medical or a self-reported diagnosis of CFS/ME. Phase 1 involved the creation of a database. Phase 2: five participants were selected from database, dependent on their proximity to Newcastle.InterventionsThe De Paul fatigue questionnaire itemised symptoms of CFS/ME, the Barthel Functional Outcome Measure and demographic questions were collected via postal return. For phase 2, five participants were subsequently invited to participate in the pilot study.Results483 questionnaire packs were requested, 63 were returned in various stages of completion. 56 De Paul fatigue questionnaires were returned: all but 12 met one of the CFS/ME criteria, but 12 or 22% of individuals did not fulfil the Fukuda nor the Clinical Canadian Criteria CFS/ME diagnostic criteria but 6 of them indicated that their fatigue was related to other causes and they barely had any symptoms. The five pilot participants completed 60% of the planned visits.ConclusionsSeverely affected CFS/ME individuals are keen to participate in research, however, their symptom burden is great and quality of life is poor. These factors must be considered when planning research and methods of engaging with such a cohort.

scholarly journals Circulating extracellular vesicles as potential biomarkers in chronic fatigue syndrome/myalgic encephalomyelitis: an exploratory pilot study

2018 ◽  
Vol 7 (1) ◽  
pp. 1453730 ◽  
Author(s):  
Jesús Castro-Marrero ◽  
Esther Serrano-Pertierra ◽  
Myriam Oliveira-Rodríguez ◽  
Maria Cleofé Zaragozá ◽  
Alba Martínez-Martínez ◽  
...  
Keyword(s):  
Pilot Study ◽  
Chronic Fatigue Syndrome ◽  
Extracellular Vesicles ◽  
Chronic Fatigue ◽  
Myalgic Encephalomyelitis ◽  
Fatigue Syndrome ◽  
Potential Biomarkers

scholarly journals Changes in circulating microRNA after recumbent isometric yoga practice by patients with myalgic encephalomyelitis/chronic fatigue syndrome: an explorative pilot study

2019 ◽  
Vol 13 (1) ◽  
Author(s):  
Shu Takakura ◽  
Takakazu Oka ◽  
Nobuyuki Sudo
Keyword(s):  
Pilot Study ◽  
Chronic Fatigue Syndrome ◽  
Mirna Expression ◽  
Chronic Fatigue ◽  
Myalgic Encephalomyelitis ◽  
University Hospital ◽  
Circulating Microrna ◽  
Post Intervention ◽  
Fatigue Syndrome ◽  
Isometric Yoga

Abstract Background Yoga is a representative mind-body therapy. Our previous studies have demonstrated that isometric yoga (i.e. yoga programs that we developed so individuals can practice yoga poses with a self-adjustable isometric load) reduces the fatigue of patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS); however, the underlying mechanisms remain unclear. Several studies have suggested that the micro-ribonucleic acid (miRNA) expression of ME/CFS patients is different from that of healthy subjects. However, it has not to date been determined if the practice of isometric yoga can affect miRNA expression. Therefore, we sought to investigate if isometric yoga is associated with changes in the expression levels of serum miRNA of patients with ME/CFS. Methods The study included nine patients with ME/CFS who failed to show satisfactory improvement after at least 6 months of treatment administered at our hospital. Patients practiced recumbent isometric yoga for 3 months; they met with a yoga instructor every 2 to 4 weeks and participated in daily in-home sessions. The effect of recumbent isometric yoga on fatigue was assessed by comparing pre- and post-intervention scores on the Japanese version of the 11-item Chalder fatigue scale (CFQ 11). Patient blood samples were drawn pre- and post-intervention, just prior to practicing recumbent isometric yoga with an instructor. The serum was used for miRNA array analysis with known human miRNAs. Results The average CFQ 11 score decreased significantly (from 25.3 ± 5.5 to 17.0 ± 5.8, p <  0.0001) after practicing recumbent isometric yoga for 3 months. The miRNA microarray analysis revealed that four miRNAs were significantly upregulated, and 42 were downregulated after the intervention period. Conclusions This explorative pilot study is the first to demonstrate changes in the serum levels of several miRNAs after regular practice of recumbent isometric yoga. These miRNAs might represent biomarkers for the fatigue-relieving effects of isometric yoga of patients with ME/CFS. Trial registration University Hospital Medical Information Network (UMIN CTR) 000023472. Registered Aug 4, 2016.

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