scholarly journals Epigenetic Alterations of the Promoter Region of the POMC Gene in Adolescent Depressive Disorder Patients with Nonsuicidal Self-injury Behaviors

2020 ◽  
Vol Volume 13 ◽  
pp. 997-1008
Author(s):  
Doudou Zheng ◽  
Xiaojiao Bi ◽  
Tianliang Zhang ◽  
Chao Han ◽  
Tantan Ma ◽  
...  
Keyword(s):  
Depressive Disorder ◽  
Promoter Region ◽  
Epigenetic Alterations ◽  
Self Injury ◽  
Em Gene ◽  
Nonsuicidal Self Injury

scholarly journals Cognitive Impairment in Adolescent Major Depressive Disorder With Nonsuicidal Self-Injury: Evidence Based on Multi-indicator ERPs

2021 ◽  
Vol 15 ◽  
Author(s):  
Yujiao Wen ◽  
Xuemin Zhang ◽  
Yifan Xu ◽  
Dan Qiao ◽  
Shanshan Guo ◽  
...  
Keyword(s):  
Middle School ◽  
Major Depressive Disorder ◽  
Cognitive Impairment ◽  
Cognitive Function ◽  
Middle School Students ◽  
Depressive Disorder ◽  
School Students ◽  
Major Depressive ◽  
Self Injury ◽  
Nonsuicidal Self Injury

The lifetime prevalence of major depressive disorder (MDD) in adolescents is reported to be as high as 20%; thus, MDD constitutes a significant social and public health burden. MDD is often associated with nonsuicidal self-injury (NSSI) behavior, but the contributing factors including cognitive function have not been investigated in detail. To this end, the present study evaluated cognitive impairment and psychosocial factors in associated with MDD with NSSI behavior. Eighteen and 21 drug-naïve patients with first-episode MDD with or without NSSI (NSSI+/– group) and 24 healthy control subjects (HC) were enrolled in the study. The Hamilton Anxiety Scale (HAMA), Hamilton Depression Scale (HAMD), Adolescent Self-injury Questionnaire, Beck Scale for Suicide Ideation–Chinese Version (BSI-CV), Shame Scale for Middle School Students, Sensation Seeking Scale (SSS) and Childhood Trauma Questionnaire (CTQ) were used to assess depression-related behaviors, and event-related potentials (ERPs) were recorded as a measure of cognitive function. The latency of the N1, N2, P3a, P3b, and P50 components of ERPs at the Cz electrode point; P50 amplitude and P50 inhibition (S1/S2) showed significant differences between the 3 groups. CTQ scores also differed across three groups, and the NSSI– and NSSI+ groups showed significant differences in scores on the Shame Scale for Middle School Students. Thus, cognitive function was impaired in adolescents with MDD with NSSI behavior, which was mainly manifested as memory decline, attention and executive function deficits, and low anti-interference ability. We also found that childhood abuse, lack of social support, and a sense of shame contributed to NSSI behavior. These findings provide insight into the risk factors for MDD with NSSI behavior, which can help mental health workers more effectively diagnose and treat these patients.

scholarly journals Epigenetic alterations of the promoter region of the POMC gene in adolescent depressive disorder patients with non-suicidal self-injury behaviors

2020 ◽  
Author(s):  
Doudou Zheng ◽  
Xiaojiao Bi ◽  
Tianliang Zhang ◽  
Chao Han ◽  
Tantan Ma ◽  
...  
Keyword(s):  
Depressive Disorder ◽  
Methylation Level ◽  
Promoter Region ◽  
Depression Scale ◽  
Epigenetic Mechanism ◽  
Psychotic Symptoms ◽  
Control Group ◽  
Hamilton Depression Scale ◽  
Female Patients ◽  
Self Injury

Abstract Background The incidence of non-suicidal self-injury (NSSI) behavior among adolescents increases year by year. Patients with a history of both depression and NSSI behaviors tend to have greater risk of suicide. At present, the mechanism of adolescent depressive disorder patients with NSSI behaviors is not clear, epigenetic mechanism may be involved. Proopiomelanocortin (POMC) gene may be associated with depressive disorder. The purpose of this study was to investigate deoxyribonucleic acid (DNA) methylation of POMC gene promoter region of adolescent depressive disorder patients with NSSI behaviors. Methods Bisulfite Sequencing PCR (BSP) was used to test the methylation level of POMC promoter of 15 adolescent depressive disorder patients with NSSI behaviors and 15 healthy controls (HC). The online software Methylation Share Rate (MSR) Calcalate was used to draw the lollipop model of the methylation state. Self-made questionnaires were used to collect clinical data of the case group and control group. Hamilton depression scale-24 (HAMD-24), Hamilton anxiety scale (HAMA), Symptom Checklist-90 (SCL-90) were used to evaluate the characteristics and severity of depressive, anxiety and psychotic symptoms. Adolescent self-injury questionnaire was used to assess NSSI behaviors and its severity. Results BSP analysis found that the POMC methylation level of cytosine-guanine dinucleotide 1 (CpG1) site was higher in adolescent depressive disorder patients with NSSI behaviors than that of HC (P < 0.05). Overall significance in POMC methylation at CpG1 sites between adolescent depressive disorder patients with NSSI behaviors and HC was gender-independent, methylation level at CpG1 sites was higher in both male and female patients than that in HC. The CpG1 methylation had correlation with the family history (P < 0.05). We also found that POMC methylation level at CpG17 sites in female patients was significantly higher than that of the female HC (P < 0.05). Conclusions There was abnormal methylation in the POMC promoter region of adolescent depressive disorder patients with NSSI behaviors, the methylation of CpG1 sites may act as epigenetic markers for those adolescents.

scholarly journals Relationship between SIRT1 gene and adolescent depressive disorder with nonsuicidal self-injury behavior

Medicine ◽  
2021 ◽  
Vol 100 (31) ◽  
pp. e26747
Author(s):  
Lina Wang ◽  
Doudou Zheng ◽  
Lanfen Liu ◽  
Gengkun Zhong ◽  
Xiaojiao Bi ◽  
...  
Keyword(s):  
Depressive Disorder ◽  
Self Injury ◽  
Sirt1 Gene ◽  
Nonsuicidal Self Injury

Self-Injurious Behavior vs. Nonsuicidal Self-Injury

Crisis ◽  
2012 ◽  
Vol 33 (2) ◽  
pp. 106-112 ◽  
Author(s):  
Christopher M. Bloom ◽  
Shareen Holly ◽  
Adam M. P. Miller
Keyword(s):  
Positive Reinforcement ◽  
Empirical Investigation ◽  
High Stress ◽  
Animal Research ◽  
Stress Conditions ◽  
Human Populations ◽  
Pharmacological Interventions ◽  
Self Injury ◽  
Cns Stimulant ◽  
Nonsuicidal Self Injury

Background: Historically, the field of self-injury has distinguished between the behaviors exhibited among individuals with a developmental disability (self-injurious behaviors; SIB) and those present within a normative population (nonsuicidal self-injury; NSSI),which typically result as a response to perceived stress. More recently, however, conclusions about NSSI have been drawn from lines of animal research aimed at examining the neurobiological mechanisms of SIB. Despite some functional similarity between SIB and NSSI, no empirical investigation has provided precedent for the application of SIB-targeted animal research as justification for pharmacological interventions in populations demonstrating NSSI. Aims: The present study examined this question directly, by simulating an animal model of SIB in rodents injected with pemoline and systematically manipulating stress conditions in order to monitor rates of self-injury. Methods: Sham controls and experimental animals injected with pemoline (200 mg/kg) were assigned to either a low stress (discriminated positive reinforcement) or high stress (discriminated avoidance) group and compared on the dependent measures of self-inflicted injury prevalence and severity. Results: The manipulation of stress conditions did not impact the rate of self-injury demonstrated by the rats. The results do not support a model of stress-induced SIB in rodents. Conclusions: Current findings provide evidence for caution in the development of pharmacotherapies of NSSI in human populations based on CNS stimulant models. Theoretical implications are discussed with respect to antecedent factors such as preinjury arousal level and environmental stress.

Exploring Particular Facets of Cognitive Emotion Regulation and Their Relationships With Nonsuicidal Self-Injury Among Adolescents

Crisis ◽  
2019 ◽  
Vol 40 (4) ◽  
pp. 280-286 ◽  
Author(s):  
Nir Madjar ◽  
Nicole Segal ◽  
Gilad Eger ◽  
Gal Shoval
Keyword(s):  
Emotion Regulation ◽  
High School Students ◽  
Analysis Of Covariance ◽  
Depression Symptoms ◽  
Emotion Regulation Strategies ◽  
Cognitive Emotion Regulation ◽  
School Students ◽  
Self Injury ◽  
Regulation Strategies ◽  
Nonsuicidal Self Injury

Abstract. Background: Nonsuicidal self-injury (NSSI) has been found to be associated with poor emotion regulation. Aims: The goal of this study was to examine the association of multidimensional cognitive emotion regulation strategies with NSSI among adolescents and compare the different patterns of NSSI. Method: A sample of 594 high-school students (54.4% boys; mean age = 14.96 years), from five regional schools across Israel, were assessed for five facets of cognitive emotion regulation strategies (acceptance, refocus on planning, positive refocusing, putting into perspective, and positive reappraisal) and NSSI behaviors using validated scales. Participants were allocated into three groups: repetitive NSSI (more than six occasions of NSSI; 7.1%), occasional NSSI (at least one incident but less than six; 8.3%), and no NSSI (84.6%). Results: Analysis of covariance, controlling for gender and depression symptoms, revealed that students with NSSI reported higher levels of acceptance, but lower levels of refocus on planning and putting into perspective. Limitations: The study used a cross-sectional design, which was a limitation. Conclusion: These findings demonstrate that particular cognitive emotion regulation strategies differ substantially in their relationship with NSSI. Adolescents who focus on planning and putting stressful situations into perspective may have increased resilience, whereas adolescents who are accepting of negative events that have happened may be more prone to maladaptive coping behaviors.

Role of Adaptive Coping Strategies in Adolescent Nonsuicidal Self-Injury

2013 ◽  
Author(s):  
Amy Kranzler ◽  
Emily A. Panza ◽  
Matthew K. Nock ◽  
Edward A. Selby
Keyword(s):  
Coping Strategies ◽  
Adaptive Coping ◽  
Self Injury ◽  
Nonsuicidal Self Injury
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