scholarly journals Inflammatory bowel disease patients prioritize mucosal healing, symptom control, and pain when choosing therapies: results of a prospective cross-sectional willingness-to-pay study

2018 ◽  
Vol Volume 12 ◽  
pp. 505-513 ◽  
Author(s):  
James Gregor ◽  
Martin Williamson ◽  
Dorota Dajnowiec ◽  
Bernie Sattin ◽  
Erik Sabot ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Willingness To Pay ◽  
Bowel Disease ◽  
Symptom Control ◽  
Mucosal Healing ◽  
Cross Sectional ◽  
Inflammatory Bowel

Soluble Blood Markers of Mucosal Healing in Inflammatory Bowel Disease: The Future of Noninvasive Monitoring

2019 ◽  
Vol 26 (6) ◽  
pp. 961-969 ◽  
Author(s):  
Olga Maria Nardone ◽  
Uday Nagesh Shivaji ◽  
Vittoria Ferruzza ◽  
Subrata Ghosh ◽  
Marietta Iacucci
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Symptom Control ◽  
Mucosal Healing ◽  
Treat To Target ◽  
New Paradigm ◽  
Frequent Monitoring ◽  
Fecal Markers ◽  
Inflammatory Bowel ◽  
Noninvasive Biomarkers

Abstract The traditional management of inflammatory bowel disease (IBD) based on symptom control is not considered valid anymore by most specialists in this field, and a new paradigm called “treat to target” has been introduced. This is based on the assessment of disease activity using objective measures. The identification of noninvasive biomarkers is crucial to diagnosis and monitor IBD because frequent endoscopic examinations are costly and uncomfortable for the patient. In this review, we focus on blood markers that may be able to assess mucosal healing (MH) in IBD and recent advances in this area. Introduction of commercial panel to predict MH opens the way for further developments so that colonoscopy or fecal markers may be avoided in some patients. This may also permit frequent monitoring for therapeutic response and achieve MH. It is a challenging area of research to identify a panel of biomarkers that may reflect inflammation and healing to serve as a surrogate of MH.

scholarly journals Capsule endoscopy in inflammatory bowel disease: when and how

2020 ◽  
Vol 18 (3) ◽  
pp. 265-274
Author(s):  
Ida Hilmi ◽  
Taku Kobayashi
Keyword(s):  
Inflammatory Bowel Disease ◽  
Small Bowel ◽  
Capsule Endoscopy ◽  
Bowel Disease ◽  
Scoring Systems ◽  
Postoperative Recurrence ◽  
Mucosal Healing ◽  
Cross Sectional ◽  
Inflammatory Bowel ◽  
Capsule Retention

Capsule endoscopy (CE) is emerging as an important investigation in inflammatory bowel disease (IBD); common types include the standard small bowel CE and colon CE. More recently, the pan-enteric CE was developed to assess the large and small bowel in patients with Crohn’s disease (CD). Emerging indications include noninvasive assessment for mucosal healing (both in the small bowel and the colon) and detection of postoperative recurrence in patients with CD. Given the increasing adoption, several CE scoring systems have been specifically developed for IBD. The greatest concern with performing CE, particularly in CD, is capsule retention, but this can be overcome by performing cross-sectional imaging such as magnetic resonance enterography and using patency capsules before performing the procedure. The development of software for automated detection of mucosal abnormalities typically seen in IBD may further increase its adoption.

scholarly journals Optimal Range of Fecal Calprotectin for Predicting Mucosal Healing in Patients with Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis

2021 ◽  
pp. 1-11
Author(s):  
Bing-Jie Xiang ◽  
Min Jiang ◽  
Ming-Jun Sun ◽  
Cong Dai
Keyword(s):  
Inflammatory Bowel Disease ◽  
Diagnostic Accuracy ◽  
Likelihood Ratio ◽  
Sensitivity And Specificity ◽  
Bowel Disease ◽  
Meta Analysis ◽  
Positive Likelihood Ratio ◽  
Fecal Calprotectin ◽  
Mucosal Healing ◽  
Inflammatory Bowel

<b><i>Objective:</i></b> Fecal calprotectin (FC) is a promising marker for assessment of inflammatory bowel disease (IBD) activity. However, the utility of FC for predicting mucosal healing (MH) of IBD patients has yet to be clearly demonstrated. The objective of our study was to perform a meta-analysis evaluating the diagnostic accuracy of FC in predicting MH of IBD patients. <b><i>Methods:</i></b> We systematically searched the databases for studies from inception to April 2020 that evaluated MH in IBD. The methodological quality of each study was assessed according to the Quality Assessment of Diagnostic Accuracy Studies checklist. The extracted data were pooled using a summary receiver operating characteristic curve model. Random-effects model was used to summarize the diagnostic odds ratio, sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio. <b><i>Results:</i></b> Sixteen studies comprising 1,682 ulcerative colitis (UC) patients and 4 studies comprising 221 Crohn’s disease (CD) patients were included. The best performance of FC for predicting MH in UC was at cut-off range of 60–75 μg/g with area under the curve (AUC) of 0.88 and pooled sensitivity and specificity of 0.87 and 0.79, respectively. The pooled sensitivity and specificity values of cutoff range 180–250 μg/g for predicting MH in CD were 0.67 and 0.76, respectively. The AUC of 0.79 also revealed improved discrimination for identifying MH in CD with FC concentration. <b><i>Conclusion:</i></b> Our meta-analysis has found that FC is a simple, reliable noninvasive marker for predicting MH in IBD patients. FC cutoff range 60–75 μg/g appears to have the best overall accuracy in UC patients.

Therapy experiences and preferences among patients with anemia: Results of a cross-sectional survey among Italian patients with inflammatory bowel disease

2017 ◽  
Vol 49 (10) ◽  
pp. 1098-1103
Author(s):  
Sonja Milovanovic ◽  
Franco Scaldaferri ◽  
Stefania Canarecci ◽  
Flavia Kheiraoui ◽  
Giulia Ciancarella ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Inflammatory Bowel

Prospective, Observational, Cross-Sectional Study of Intestinal Infections among Acutely Active Inflammatory Bowel Disease Patients

Digestion ◽  
2009 ◽  
Vol 80 (1) ◽  
pp. 25-29 ◽  
Author(s):  
Merc&egrave; Navarro-Llavat ◽  
Eugeni Dom&egrave;nech ◽  
Isabel Bernal ◽  
Jordi S&aacute;nchez-Delgado ◽  
Jos&eacute; M. Manterola ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Active Inflammatory Bowel Disease ◽  
Intestinal Infections ◽  
Inflammatory Bowel
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