scholarly journals Effect of Obesity on Soluble Vascular Cell–Adhesion Molecules, Fibrinogen, and von Willebrand Factor Antigen among Obese People in Sapele, Southern Nigeria

2021 ◽  
Vol Volume 13 ◽  
pp. 21-26
Author(s):  
Kingsley Amaihunwa ◽  
Emmanuel A Etim ◽  
Everista Osime ◽  
Zacchaeus A Jeremiah
Keyword(s):  
Cell Adhesion ◽  
Von Willebrand Factor ◽  
Cell Adhesion Molecules ◽  
Vascular Cell Adhesion ◽  
Obese People ◽  
Vascular Cell ◽  
Southern Nigeria ◽  
Von Willebrand ◽  
Willebrand Factor ◽  
Factor Antigen

Comparative Study of Intranasal, Subcutaneous and Intravenous Administration of Desamino-D-Arginine Vasopressin (DDAVP)

1986 ◽  
Vol 55 (01) ◽  
pp. 108-111 ◽  
Author(s):  
M Köhler ◽  
P Hellstern ◽  
C Miyashita ◽  
G von Blohn ◽  
E Wenzel
Keyword(s):  
Factor Viii ◽  
Von Willebrand Factor ◽  
Factor Xii ◽  
Additional Advantage ◽  
Mean Values ◽  
Routes Of Administration ◽  
The Mean ◽  
Von Willebrand ◽  
Willebrand Factor ◽  
Factor Antigen

SummaryThis study was performed to evaluate the influence of different routes of administration on the efficacy of DDAVP treatment. Ten healthy volunteers received DDAVP intranasally (i.n.), subcutaneously (s.c.) and intravenously (i.v.) in a randomized cross-over trial. Factor XII and high molecular weight (HMW)-kininogen levels increased only slightly after DDAVP administration. The mean increase of factor VIII: C was 3.1 (i. v.), 2.3 (s. c.), and 1.3 (i.n.) - fold over baseline. Ristocetin cofactor (von Willebrand factor antigen) increased 3.1 (2.5), 2.0 (2.3) and 1.2 (1.2) - fold over baseline mean values after i.v., s.c. and i.n. DDAVP, respectively. The half-disappearance time of factor VIII and von Willebrand factor (vWF) after DDAVP ranged from five (factor VIII: C) to eight hours (vWF). The mean increase of fibrinolytic activity was more pronounced after i.v. DDAVP. The antidiuretic effect was moderate with no apparent differences between the routes of application. This study provides further evidence that both i.v. and s.c. DDAVP administration result in an appropriate and reliable stimulation of haemostasis. An additional advantage of s. c. administration is its suitability for home treatment.

scholarly journals Plasma levels of von Willebrand factor antigen in acute bronchitis and in a normal population

1998 ◽  
Vol 92 (3) ◽  
pp. 395-400 ◽  
Author(s):  
D.A.R. Boldy ◽  
P.E. Short ◽  
P. Cowen ◽  
F.G.H. Hill ◽  
D.C. Chambers ◽  
...  
Keyword(s):  
Von Willebrand Factor ◽  
Plasma Levels ◽  
Normal Population ◽  
Acute Bronchitis ◽  
Von Willebrand Factor Antigen ◽  
Von Willebrand ◽  
Willebrand Factor ◽  
Factor Antigen

scholarly journals Assessment of Plasma von Willebrand factor antigen in non-metastatic Prostate Cancerpatients: across-sectional study of the Sudanese Population

2019 ◽  
Author(s):  
Mohammed Othman Hashim ◽  
Gad Allah Modawe ◽  
Ibrahim Khider Ibrahim
Keyword(s):  
Prostate Cancer ◽  
Von Willebrand Factor ◽  
Enzyme Linked Immunosorbent Assay ◽  
Sectional Study ◽  
High Concentration ◽  
Cross Sectional ◽  
Von Willebrand Factor Antigen ◽  
Von Willebrand ◽  
Willebrand Factor ◽  
Factor Antigen

Backgrounds: VonWillebrand disease (VWD) is reportedly the most common inherited bleeding disorder and can also arise as an acquired syndrome (AVWS). These disorders arise due to defects and/or deficiency of the plasma protein von Willebrand factor (VWF)..High plasma vWF concentrations have been reported in patients with various types of cancer, such as prostatic cancer.Metastasization may be associated with activation of haemostatic processes resulting in increased levels of circulating factor VIII-related antigen (FVIIIRAg) (von Willebrand factor antigen). Objective: To evaluate the status of VWF AginSudanese patients with Prostate Cancer attending RICK Methodology: This is a cross-sectional study carried out in Khartoum state at Khartoum oncology (RICK) hospital, during the period from April to June 2018, 45 samples were collected from patients with non-metastatic CA prostate, their ages ranged between 51 to 82 years. The vWF level was measured using Enzyme-linked immunosorbent assay (ELISA). Data were analyzed by the statistical package for social science (SPSS).   Results: Serology for vWF antigen was done for 45 cases of prostate cancer. According to the age, 2(8%) of patients with age 51-66 had a high concentration of VWF while 24(92%) had normal vWF antigen concentration; of those with age 67-82 years, 4(21%) had high vWF antigen and 15(79%) had normal antigen. Conclusion: The study revealedthat more than 80% of Sudanese patients withnon-metastatic prostate cancer have anormal concentration of VWF. Keywords: vWF, Prostate cancer, Age, ELISA

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