scholarly journals Genetic Variant of PP2A Subunit Gene Confers an Increased Risk of Primary Liver Cancer in Chinese

2021 ◽  
Vol Volume 14 ◽  
pp. 1565-1574
Author(s):  
Youxin Wang ◽  
Qiuyue Huang ◽  
Xinglei Huang ◽  
Huiliu Zhao ◽  
Bin Guan ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Genetic Variant ◽  
Primary Liver Cancer ◽  
Subunit Gene ◽  
Increased Risk

scholarly journals Total Cholesterol, Alanine Aminotransferase And the Risk of Primary Liver Cancer: A Population-based prospective study

2020 ◽  
Author(s):  
Miaomiao Sun ◽  
Wanchao Wang ◽  
Xining Liu ◽  
Yiming Wang ◽  
Haozhe Cui ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Total Cholesterol ◽  
Alanine Aminotransferase ◽  
Proportional Hazards ◽  
Primary Liver Cancer ◽  
Joint Effect ◽  
Cox Proportional Hazards ◽  
Additive Models ◽  
Low Level ◽  
Increased Risk

Abstract Background: Previous studies have shown that serum total cholesterol(TC) and serum alanine aminotransferase(ALT) were associated with liver cancer risk, respectively. However, the common contribution of TC and normal-high ALT to primary liver cancer(PLC) has not been reported to date. We aim to assess the separate and joint effect of low TC level and normal-high ALT level on the risk of PLC, a large prospective cohort was conducted in our study.Methods: The participants were divided into 4 groups via cross-matching method according to TC[low level(-)/ non-low level(+)] and ALT[normal level(-)/ normal-high level(+)] status, and using the lower quartile(P25) value(4.24 mmol/L) of TC and the upper quartile(P75) value(22 U/L) of ALT as a threshold, respectively. Incident PLC was confirmed by review of medical records. Cox proportional hazards regression models and interactive additive models were used to evaluate whether the joint effect of low TC level and normal-high ALT level is associated with the risk of PLC.Results: During 1,248,895 person-years follow-up, 298 participants were diagnosed with PLC among 114,972 subjects. TC＜4.24 mmol/L for the “TC(-)” group; TC≥4.24 mmol/L for the “TC(+)” group; ALT＜22U/L for the “ALT(-)” group; ALT≥22U/L for the “ALT(+)”. Compared with the “TC(+)” group, “ALT(-)” group, respectively, the adjusted hazard ratio(HR) and 95% confidence interval(95%CI) for PLC risk was 1.71 (1.34-2.19) in “TC(-)” group and for PLC risk was 1.52 (1.18-1.95) in “ALT(+)” group. In combinatorial analysis, compared with “TC(+) and ALT(-)” group, the significant increased risk of PLC were observed in “TC(+) and ALT(+)” group (HR=1.45; 95%CI: 1.07-1.97), “TC(-) and ALT(-)” group(HR=1.64; 95%CI: 1.21-2.22) and “TC(-) and ALT(+)” group(HR=2.70; 95%CI: 1.84-3.96), respectively. The interaction between “TC(-)” and “ALT (+)” on the risk of PLC was not significant(Pinteraction=0.26). Conclusions: Both low TC level and normal-high ALT level were risk factors of PLC. There is the separate and joint effect of low TC level and normal-high ALT level on the risk of PLC.Trial registration: ChiCTR-TNRC-11001489. Registered August 24, 2011 (retrospectively registered)

scholarly journals Increased risk for primary liver cancer among women exposed to solvents.

1988 ◽  
Vol 14 (6) ◽  
pp. 356-365 ◽  
Author(s):  
Sven Hernberg ◽  
Timo Kauppinen ◽  
Riitta Riala ◽  
M L Korkala ◽  
U Asikainen
Keyword(s):  
Liver Cancer ◽  
Primary Liver Cancer ◽  
Increased Risk

scholarly journals Total cholesterol, alanine aminotransferase and the risk of primary liver cancer: A population-based prospective study in China

2020 ◽  
Author(s):  
Miaomiao Sun ◽  
Wanchao Wang ◽  
Yiming Wang ◽  
Haozhe Cui ◽  
Xining Liu ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Total Cholesterol ◽  
Alanine Aminotransferase ◽  
Proportional Hazards ◽  
Primary Liver Cancer ◽  
Joint Effect ◽  
Cox Proportional Hazards ◽  
Additive Models ◽  
Low Level ◽  
Increased Risk

Abstract Background: Previous studies have shown that serum total cholesterol(TC) and serum alanine aminotransferase(ALT) were associated with liver cancer risk, respectively. However, the common contribution of TC and normal-high ALT to primary liver cancer(PLC) has not been reported to date. We aim to assess the separate and joint effect of low TC level and normal-high ALT level on the risk of PLC, a large prospective cohort was conducted in our study. Method: The participants were divided into 4 groups via mismarch method according to TC[low level(-)/ non-low level(+)] and ALT[normal level(-)/ normal-high level(+)] status, and using the lower quartile(P25) value(4.24 mmol/L) of TC and the upper quartile(P75) value(22 U/L) of ALT as a cut point, respectively. Incident PLC was confirmed by review of medical records. Cox proportional hazards regression models and interactive additive models were used to evaluate whether the joint effect of low TC level and normal-high ALT level is associated with the risk of PLC. Results: During 1,248,895 person-years of follow-up, 298 participants were diagnosed with PLC among 114,972 subjects. TC＜4.24 mmol/L for the “TC(-)” group; TC≥4.24 mmol/L for the “TC(+)” group; ALT＜22U/L for the “ALT(-)” group; ALT≥22U/L for the “ALT(+)”. Compared with the “TC(+)” group and “ALT(-)” group, respectively, the adjusted hazard ratio(HR) and 95% confidence interval(95%CI) of “TC(-)” group for PLC risk was 1.71 (1.34-2.19) and of “ALT(+)” group for PLC risk was 1.52 (1.18-1.95). In combinatorial analysis, compared with the group of “TC(+) with ALT(-)”, the significant increased risk of PLC were observed in “TC(+) with ALT(+) group”(HR=1.45; 95%CI: 1.07-1.97), “TC(-) with ALT(-)” group(HR=1.64; 95%CI: 1.21-2.22) and “TC(-) with ALT(+)” group(HR=2.70; 95%CI: 1.84-3.96), respectively. The interaction term between “TC(-)” and “ALT (+)” on the risk of PLC was not significant(Pinteraction=0.26). Conclusions: Both low TC level and normal-high ALT level were strong predictors of PLC. Individuals with low TC level and normal-high ALT level, would extremely increase the risk of PLC.Trial registration: ChiCTR-TNRC-11001489. Registered August 24, 2011 (retrospectively registered)

scholarly journals Increased Porphyrins in Primary Liver Cancer Mainly Reflect a Parallel Liver Disease

2009 ◽  
Vol 2009 ◽  
pp. 1-6 ◽  
Author(s):  
Jerzy Kaczynski ◽  
Göran Hansson ◽  
Sven Wallerstedt
Keyword(s):  
Liver Disease ◽  
Liver Cancer ◽  
Aminolevulinic Acid ◽  
Primary Liver Cancer ◽  
Clinical Signs ◽  
Liver Disorder ◽  
Liver Disorders ◽  
Increased Risk ◽  
History Of

Hepatic porphyries have been associated with an increased risk of primary liver cancer (PLC), which on the other hand may cause an increased porphyrin production. To evaluate the role of an underlying liver disorder we analyzed porphyrins in patients with hepatocellular carcinoma (HCC)(n=65), cholangiocellular carcinoma(n=3), or suspected PLC, which turned out to be metastases(n=18)or a benign disorder(n=11). None of the patients had a family history of porphyry or clinical signs of porphyry. Increased aminolevulinic acid or porphyrin values were common not only in patients with PLC (43%) but also in metastatic (50%) and benign (64%) liver disorders. The corresponding proportion for HCC patients with liver cirrhosis (55%) was higher(P<.05)than in those without cirrhosis (17%). We conclude that symptomatic porphyries are unusual in PLC, whereas elevated urinary and/or faecal porphyrins are common, primarily reflecting a parallel liver disease and not the PLC.

Pathomorphological study on primary liver cancer

Kanzo ◽  
1979 ◽  
Vol 20 (8) ◽  
pp. 828-838 ◽  
Author(s):  
Sadaaki KUWAO
Keyword(s):  
Liver Cancer ◽  
Primary Liver Cancer
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