scholarly journals Acetylator Status Among Newly Diagnosed and Recurrent Tuberculosis Patients from Kupang, Eastern Part of Indonesia

2021 ◽  
Vol Volume 14 ◽  
pp. 737-744
Author(s):  
Edhyana Sahiratmadja ◽  
Ika Agus Rini ◽  
Simeon Penggoam ◽  
Afandi Charles ◽  
Ani Melani Maskoen ◽  
...  
Keyword(s):  
Newly Diagnosed ◽  
Tuberculosis Patients ◽  
Acetylator Status ◽  
Recurrent Tuberculosis

scholarly journals Sequence analysis of the rifampicin resistance determining region (RRDR) of rpoB gene in multidrug resistance confirmed and newly diagnosed tuberculosis patients of Punjab, Pakistan

PLoS ONE ◽  
2017 ◽  
Vol 12 (8) ◽  
pp. e0183363 ◽  
Author(s):  
Salma Hameed ◽  
Kartyk Moganeradj ◽  
Nasir Mahmood ◽  
Timothy D. McHugh ◽  
Muhammad Nawaz Chaudhry ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Sequence Analysis ◽  
Rpob Gene ◽  
Rifampicin Resistance ◽  
Newly Diagnosed ◽  
Tuberculosis Patients

scholarly journals Comparison of neurocognitive changes among newly diagnosed tuberculosis patients with and without dysglycaemia

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Ernest Yorke ◽  
Vincent Boima ◽  
Ida Dzifa Dey ◽  
Vincent Ganu ◽  
Norah Nkornu ◽  
...  
Keyword(s):  
Newly Diagnosed ◽  
Tuberculosis Patients

scholarly journals Oxidative stress biomarkers in pulmonary tuberculosis patients in Gombe, North-eastern Nigeria

2019 ◽  
Vol 10 (6) ◽  
pp. 57-62 ◽  
Author(s):  
Mohammed Haruna Yeldu ◽  
Yakubu Ibrahim ◽  
Shehu Abubakar Akuyam ◽  
Isah Muhammad Danasabe ◽  
Buhari Shehu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Pulmonary Tuberculosis ◽  
Total Antioxidant Status ◽  
Serum Levels ◽  
Newly Diagnosed ◽  
Oxidative Stress Biomarkers ◽  
Tuberculosis Patients ◽  
Stress Biomarkers ◽  
North Eastern ◽  
Total Antioxidant

Background: Oxidative stress may play an important role in the pathogenesis of pulmonary tuberculosis (PTB). To our knowledge there is paucity of data on the status of oxidative stress biomarkers among PTB patients in Gombe, North-eastern Nigeria. Our study was designed to evaluate the oxidative stress biomarkers in pulmonary tuberculosis patients in Gombe, North-eastern Nigeria. Aims and Objectives: To determine the serum levels of oxidative stress biomarkers among patients with pulmonary tuberculosis in Gombe metropolis, North-eastern Nigeria and to assess the correlation between the oxidative stress biomarkers in pulmonary tuberculosis patients. Materials and Methods: A cross sectional comparative study was conducted in a tertiary health care facility with 40 pulmonary tuberculosis (PTB) patients on anti-TB drugs treatment (ATT), 40 newly diagnosed PTB patients not yet on anti-TB drugs treatment (ATT-naïve) and 40 age- and sex-marched apparently healthy subjects (controls). Serum total antioxidant status (TAS), total oxidant status (TOS), malondialdehyde (MDA), nitric oxide (NO) and oxidative stress index (OSI) determined using standard techniques. Data was analysed using INSTAT® (Graph Pad Software Inc., La Jolla, CA, USA). Results: Serum levels of TOS, OSI, MDA and NO were significantly (p ˂ 0.001) increased in PTB patients (ATT and ATT-naïve) when compared with healthy individuals. Serum TAS and body mass index (BMI) were significantly (p ˂ 0.001) decreased in PTB patients when compared with healthy individuals. Serum TOS significantly correlated with serum OSI, MDA and NO in ATT-naïve PTB patients. Conclusion: This study observed an increased oxidative stress biomarkers and decreased total antioxidant status in newly diagnosed pulmonary tuberculosis patients and those on treatment. Our findings suggest that antioxidants supplementation and improved nutrition in the management of pulmonary tuberculosis patients may go a long way in preventing the oxidative onslaught and further complications in PTB patients.

Eight Months vs Six Months Anti-TB Regimen in the Treatment of Newly Diagnosed Pulmonary Tuberculosis Patients in Nigeria

2015 ◽  
Vol 8 (10) ◽  
pp. 836-841 ◽  
Author(s):  
Olusoji Daniel ◽  
Olusola Adejumo ◽  
Hussein Abdulrrazzaq ◽  
Mustapha Gidado ◽  
Olajumoke Onazi ◽  
...  
Keyword(s):  
Pulmonary Tuberculosis ◽  
Newly Diagnosed ◽  
Tuberculosis Patients

scholarly journals Acquisition of Rifampin Resistance in Pulmonary Tuberculosis

2017 ◽  
Vol 61 (4) ◽  
Author(s):  
Xavier A. Kayigire ◽  
Sven O. Friedrich ◽  
Lize van der Merwe ◽  
Andreas H. Diacon
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Pulmonary Tuberculosis ◽  
Drug Distribution ◽  
Newly Diagnosed ◽  
Spontaneous Mutations ◽  
Content Type ◽  
Tuberculosis Patients ◽  
Fixed Drug ◽  
Rifampin Resistance ◽  
Temporal And Spatial

ABSTRACT Mycobacterium tuberculosis strains with spontaneous mutations conferring resistance to rifampin (RIF) are exceedingly rare, and fixed drug combinations typically prevent augmentation of resistance to single drugs. Fourteen newly diagnosed tuberculosis patients were treated with RIF alone for 14 days, and bacterial loads, including mutation frequencies, were determined. A statistical model estimated that 1% of the remaining viable mycobacteria could be RIF resistant after 30 days of monotherapy. This indicates that temporal and spatial windows of RIF monotherapy due to uneven drug distribution within lung lesions could contribute to the acquisition of resistance to RIF.

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