scholarly journals Case–Control Study on TNFRSF6B Gene Polymorphism and Susceptibility to Gastric Cancer in a Chinese Han Population

2020 ◽  
Vol Volume 13 ◽  
pp. 749-756
Author(s):  
Xuyu Gu ◽  
Zhenwei Mao ◽  
Huiwen Pan ◽  
Chen Zou ◽  
Guowen Ding ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Gene Polymorphism ◽  
Case Control Study ◽  
Case Control ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Em Gene ◽  
Control Study

scholarly journals Association of matrix Gla protein polymorphism and knee osteoarthritis in a chinese population

2019 ◽  
Vol 39 (1) ◽  
Author(s):  
Wenpeng Hui ◽  
Zhong Cao ◽  
Xiao Wang ◽  
Junfeng Zhu
Keyword(s):  
Gene Polymorphism ◽  
Knee Osteoarthritis ◽  
Case Control Study ◽  
Case Control ◽  
Matrix Gla Protein ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Knee Oa ◽  
Control Study

Abstract Several studies have explored the association between matrix Gla protein (MGP) gene polymorphism and knee osteoarthritis (OA) risk; however, they obtained conflicting findings. The present study aims to explore the association of MGP gene polymorphism and OA risk in a Chinese Han population. A total of 256 patients with radiographic knee OA and 327 control subjects were recruited in this case–control study. The genotypes of MGP gene rs1800802 polymorphism was determined by standard PCR and restriction fragment length polymorphism (PCR-RLFP). In this case–control study, we observed that MGP gene rs1800802 polymorphism increased the risk of knee OA. Subgroup analyses also found that rs1800802 polymorphism was related to the elevated risk for knee OA among the female, smoker, drinker, and body mass index (BMI) ≥25 kg/m2 groups. In conclusion, this study shows that MGP gene rs1800802 polymorphism is associated with increased risk for knee OA in Chinese Han population and the rs1800802 polymorphism may be a diagnostic marker of radiographic knee OA.

scholarly journals MATN3 Gene Polymorphism Is Associated with Osteoarthritis in Chinese Han Population: A Community-Based Case-Control Study

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Jiaao Gu ◽  
Jiesheng Rong ◽  
Fulin Guan ◽  
Liying Jiang ◽  
Shuqing Tao ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Knee Osteoarthritis ◽  
Case Control Study ◽  
Case Control ◽  
Chinese Han Population ◽  
Restriction Enzyme Digestion ◽  
Chinese Han ◽  
Community Based ◽  
Han Population ◽  
Control Study

Background. The matrilin, especially matrilin-3 (MATN3), are reported to play important roles in the pathophysiology of osteoarthritis (OA). To explore the relationship between MATN3 SNP6 (rs8176070) and primary OA, we conducted a community-based case-control study.Methods. A total of 732 community residents aged 40–84 years participated in the community-based study in Northeast China. After taking physical and radiographic examinations, 420 of the residents were diagnosed OA (216 women and 204 men). The other 312 individuals without any symptoms of osteoarthritis or signs in the radiographs (156 women and 156 men) were considered as healthy controls. After obtaining the DNA of case and control groups, genotypes of the MATN3 SNP6 were determined by polymerase chain reaction followed by restriction enzyme digestion. The numbers of patients with different OA subtypes were also calculated.Results. The distribution of genotypes and alleles of the MATN3 SNP6 between OA patients and controls was different significantly. The BB carrier tends to be associated with the increased osteoarthritis (P= 0.025, OR = 1.724, 95% CI = 1.071–2.77), especially the knee osteoarthritis (P= 0.021, OR = 2.402, 95% CI = 1.141–5.060) and lumber osteoarthritis (P= 0.020, OR = 1.880, 95% CI = 1.103–3.204). Bb carrier increased hand osteoarthritis risk (P= 0.002, OR = 5.380, 95% CI = 1.828–15.835). The B allele might have an effect on the increased knee osteoarthritis (P= 0.000, OR = 3.143, 95% CI = 2.283–4.328).Conclusion. These findings suggest that the MATN3 gene polymorphism might be associated with osteoarthritis in the Chinese Han population.

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