scholarly journals Inhibition of FOXO1 by small interfering RNA enhances proliferation and inhibits apoptosis of papillary thyroid carcinoma cells via Akt/FOXO1/Bim pathway

2015 ◽  
pp. 3565 ◽  
Author(s):  
Hong-ming Song ◽  
Jialu Song ◽  
Dengfeng Li ◽  
Kaiyao Hua ◽  
Bingkun Zhao ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Small Interfering Rna ◽  
Carcinoma Cells ◽  
Papillary Thyroid ◽  
Interfering Rna

Delivery of Small Interfering RNA. A Review and an Example of Application to a Junction Oncogene

2008 ◽  
Vol 94 (2) ◽  
pp. 254-263 ◽  
Author(s):  
Anne-Laure Ramon ◽  
Jean-Rémi Bertrand ◽  
Claude Malvy
Keyword(s):  
Rna Interference ◽  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Cancer Treatment ◽  
Antisense Oligonucleotides ◽  
Small Interfering Rna ◽  
Papillary Thyroid ◽  
Therapeutic Tool ◽  
Delivery Methods ◽  
Interfering Rna

RNA interference strategies using small interfering RNA is one of the most important discoveries in biology in recent years. This technology alongside antisense oligonucleotides is very promising and our group has focused its work on the targeting of junction oncogenes with these molecules. We have taken, as first example, papillary thyroid carcinoma. But there is a great need in delivery methods for these molecules in the treatment of cancers. Indeed, many studies have shown that small interfering RNA and antisense oligonucleotides are made efficient by various innovative delivery methods and, under these conditions, offer a powerful new therapeutic tool in cancer treatment.

TBX3 promotes proliferation of papillary thyroid carcinoma cells through facilitating PRC2-mediated p57KIP2 repression

Oncogene ◽  
2018 ◽  
Vol 37 (21) ◽  
pp. 2773-2792 ◽  
Author(s):  
Xiaomeng Li ◽  
Xianhui Ruan ◽  
Peitao Zhang ◽  
Yang Yu ◽  
Ming Gao ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Carcinoma Cells ◽  
Papillary Thyroid

scholarly journals Prognosis of Patients with Papillary Thyroid Carcinoma Located in One Lobe Showing Lateral Node Metastasis in the Contralateral but Not Ipsilateral Compartment

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Yasuhiro Ito ◽  
Takuya Higashiyama ◽  
Yuuki Takamura ◽  
Kaoru Kobayashi ◽  
Akihiro Miya ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Lateral Compartment ◽  
Carcinoma Cells ◽  
Papillary Thyroid ◽  
Lateral Node ◽  
Node Metastasis ◽  
Central Node ◽  
Central Node Metastasis ◽  
Central Node Dissection

Papillary thyroid carcinoma (PTC) frequently metastasizes to the lymph node in lateral compartment, which can often be detected on preoperative ultrasonography (N1b). However, PTC located in one lobe showing contralateral but not ipsilateral N1b is not common. We analyzed the clinicopathological features and prognosis of 13 patients with PTC limited in one lobe showing contralateral but not ipsilateral N1b. Sizes of the primary lesions ranged from 0.8 cm to 3.0 cm and only 2 tumors showed extrathyroid extension. Metastatic lateral node measured from 0.6 to 3.1 cm. Ten patients showed pathological central node metastasis and 5 had minute PTC lesions in the contralateral lobe. However, 3 patients did not show either of these. None of the patients have developed carcinoma recurrence or died of carcinoma to date. Taken together, PTC located in one lobe with contralateral but not ipsilateral N1b is rare and generally shows an indolent behavior. Although most patients had central node metastasis and/or minute PTC lesions in the contralateral lobe, it is also possible for carcinoma cells to metastasize directly from primary lesions to the contralateral lateral node. Total thyroidectomy with central node dissection and therapeutic MND of the contralateral compartment may be an acceptable surgical design and bilateral MND might not be mandatory.

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