scholarly journals Changing attitudes toward needle biopsies of breast cancer in Shanghai: experience and current status over the past 8 years

2015 ◽  
pp. 2865 ◽  
Author(s):  
Shuang Hao ◽  
Zhe Bin Liu ◽  
Hong Ling ◽  
Jia Jian Chen ◽  
Ju Ping Shen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
The Past ◽  
Changing Attitudes

NUMERICAL COEFFICIENT FOR ENDOMETRIAL CANCER INDIVIDUAL RISK EVALUATION IN POSTMENOPAUSAL WOMEN

2017 ◽  
Vol 63 (3) ◽  
pp. 461-465
Author(s):  
Lev Bershteyn ◽  
Dmitriy Vasilev ◽  
Tatyana Poroshina ◽  
Igor Berlev
Keyword(s):  
Breast Cancer ◽  
Endometrial Cancer ◽  
Risk Evaluation ◽  
Tumor Response ◽  
Molecular Genetic ◽  
Response To Treatment ◽  
Individual Risk ◽  
The Past ◽  
Genetic Landscape ◽  
Numerical Coefficient

Increased frequency of endometrial cancer (EC) since the beginning of this century exceeds that of breast cancer and to a large extent can be attributed to dynamics of parameters, which characterize hormonal and metabolic status of ill women and molecular genetic landscape of transforming endometrium. During the past few years there are suggested several options for a personalized assessment of the risk of EC. The aim of this article is to propose and justify own version of this score with the idea of its further not only retrospective but also prospective testing both in relation to the risk of developing endometrial cancer as well as an additional marker helping to predict tumor response to treatment.

Understanding Molecular Process and Chemotherapeutics for the Management of Breast Cancer.

2020 ◽  
Vol 14 ◽  
Author(s):  
Abhishek Kumar ◽  
Neeraj Masand ◽  
Vaishali M. Patil
Keyword(s):  
Breast Cancer ◽  
Molecular Mechanisms ◽  
Molecular Targets ◽  
Molecular Classification ◽  
Neoplastic Disease ◽  
Molecular Process ◽  
The Past ◽  
Anti Cancer ◽  
Molecular Etiology ◽  
Near Future

Abstract: Breast cancer is the most common and highly heterogeneous neoplastic disease comprised of several subtypes with distinct molecular etiology and clinical behaviours. The mortality observed over the past few decades and the failure in eradicating the disease is due to the lack of specific etiology, molecular mechanisms involved in initiation and progression of breast cancer. Understanding of the molecular classes of breast cancer may also lead to new biological insights and eventually to better therapies. The promising therapeutic targets and novel anti-cancer approaches emerging from these molecular targets that could be applied clinically in the near future are being highlighted. In addition, this review discusses some of the details of current molecular classification and available chemotherapeutics

scholarly journals Relationship of attitudes toward uncertainty and preventive health behaviors with breast cancer screening participation

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Miho Satoh ◽  
Naoko Sato
Keyword(s):  
Breast Cancer ◽  
Cancer Screening ◽  
Alcohol Consumption ◽  
Risk Aversion ◽  
Health Behaviors ◽  
Breast Cancer Screening ◽  
Time Preference ◽  
The Past ◽  
Screening Participation ◽  
Cancer Screening Participation

Abstract Backgroundcxs Early detection of breast cancer is effective for prolonging survival, but the participation rate in breast cancer screening among target Japanese women remains low. This study examined the relationships between tendencies in decision-making under conditions of uncertainty, health behaviors, demographics, and breast cancer screening participation in Japanese women. Methods Secondary analysis was performed using data from the 2017 Keio Household Panel Survey (KHPS). The study population consisted of 2945 households. Data were obtained from the KHPS for women aged 40 years or older. Breast cancer screening participation in the past year, risk aversion, time preference, health behaviors (e.g., smoking, alcohol consumption, and medical treatment received in the past year), and demographic variables were analyzed. Results Data from 708 women were analyzed. Among the respondents, 28.8% had attended breast cancer screening in the past year. Factors found to significantly contribute to breast cancer screening participation included higher risk aversion (odds ratio [OR], 2.34; 95% confidence interval [CI] = 1.03–5.32; p = 0.043), medical treatment received in the past year (OR, 1.56; 95% CI = 1.06–2.30; p = 0.026), higher self-rated health (OR, 1.47; 95% CI = 1.18–1.83; p = 0.001), living above the poverty line (OR, 2.31; 95% CI = 1.13–4.72; p = 0.022), and having children (OR, 1.57; 95% CI = 1.02–2.42; p = 0.042). Factors significantly associated with non-participation in breast cancer screening were smoking (OR, 0.20; 95% CI = 0.10–0.42; p < 0.000), alcohol consumption (OR, 0.56; 95% CI = 0.37–0.86; p = 0.007), being self-employed (OR, 0.22; 95% CI = 0.10–0.46; p < 0.000), and being unemployed (OR, 0.48; 95% CI = 0.26–0.90; p = 0.022). No significant relationship was observed between time preference and screening participation. Conclusions The results indicate that women who recognize the actual risk of developing breast cancer or have high awareness of breast cancer prevention tend to participate in breast cancer screening. Barriers to screening participation are not working for an organization that encourages screening and low income.

3D RECONSTRUCTION OF BREAST CANCER FROM MAMMOGRAMS USING VOLUME RENDERING TECHNIQUES

2015 ◽  
Vol 75 (2) ◽  
Author(s):  
Ho Wei Yong ◽  
Abdullah Bade ◽  
Rajesh Kumar Muniandy
Keyword(s):  
Breast Cancer ◽  
3D Reconstruction ◽  
Computational Cost ◽  
Reconstruction Method ◽  
Cancer Model ◽  
Volume Reconstruction ◽  
The Past ◽  
Breast Cancer Model ◽  
Reconstruction Software ◽  
To Come

Over the past thirty years, a number of researchers have investigated on 3D organ reconstruction from medical images and there are a few 3D reconstruction software available on the market. However, not many researcheshave focused on3D reconstruction of breast cancer’s tumours. Due to the method complexity, most 3D breast cancer’s tumours reconstruction were done based on MRI slices dataeven though mammogram is the current clinical practice for breast cancer screening. Therefore, this research will investigate the process of creating a method that will be able to reconstruct 3D breast cancer’s tumours from mammograms effectively.  Several steps were proposed for this research which includes data acquisition, volume reconstruction, andvolume rendering. The expected output from this research is the 3D breast cancer’s tumours model that is generated from correctly registered mammograms. The main purpose of this research is to come up with a 3D reconstruction method that can produce good breast cancer model from mammograms while using minimal computational cost.

scholarly journals Bloody Women: How Female Authors Have Transformed the Scottish Contemporary Crime Fiction Genre

2017 ◽  
Vol 28 (1) ◽  
pp. 52-71
Author(s):  
Lorna Hill
Keyword(s):  
Social Issues ◽  
Crime Fiction ◽  
Female Characters ◽  
Political Issues ◽  
The Past ◽  
Female Authors ◽  
Crime Novel ◽  
Practice Based Research ◽  
Changing Attitudes

Abstract This study will explore the role of female authors in contemporary Scottish crime fiction. Over the past thirty years, women writers have overhauled the traditionally male dominated genre of crime fiction by writing about strong female characters who drive the plot and solve the crimes. Authors including Val McDermid, Denise Mina and Lin Anderson are just a few of the women who have challenged the expectation of gender and genre. By setting their novels in contemporary society they reflect a range of social and political issues through the lens of a female protagonist. By closely examining the female characters, both journalists, in Val McDermid’s Lindsay Gordon series and Denise Mina’s Paddy Meehan series, I wish to explore the issue of gender through these writers’ perspectives. This essay documents the influence of these writers on my own practice-based research which involves writing a crime novel set in a post referendum Scotland. I examine a progressive and contemporary Scottish society, where women hold many senior positions in public life, and investigate whether this has an effect on the outcome of crimes. Through this narrative, my main character will focus on the current and largely hidden crimes of human trafficking and domestic abuse. By doing this I examine the ways in which the modern crime novel has evolved to cross genre boundaries. In addition to focusing on a crime, the victims and witnesses, today’s crime novels are tackling social issues to reflect society’s changing attitudes and values.

scholarly journals The Evolving Role of Ferroptosis in Breast Cancer: Translational Implications Present and Future

Cancers ◽  
2021 ◽  
Vol 13 (18) ◽  
pp. 4576
Author(s):  
Hung-Yu Lin ◽  
Hui-Wen Ho ◽  
Yen-Hsiang Chang ◽  
Chun-Jui Wei ◽  
Pei-Yi Chu
Keyword(s):  
Breast Cancer ◽  
Cell Death ◽  
Regulatory Networks ◽  
Molecular Mechanisms ◽  
Drug Resistant ◽  
Therapeutic Targeting ◽  
The Past ◽  
Regulated Cell Death ◽  
Common Malignancy

Breast cancer (BC) is the most common malignancy among women worldwide. The discovery of regulated cell death processes has enabled advances in the treatment of BC. In the past decade, ferroptosis, a new form of iron-dependent regulated cell death caused by excessive lipid peroxidation has been implicated in the development and therapeutic responses of BC. Intriguingly, the induction of ferroptosis acts to suppress conventional therapy-resistant cells, and to potentiate the effects of immunotherapy. As such, pharmacological or genetic modulation targeting ferroptosis holds great potential for the treatment of drug-resistant cancers. In this review, we present a critical analysis of the current understanding of the molecular mechanisms and regulatory networks involved in ferroptosis, the potential physiological functions of ferroptosis in tumor suppression, its potential in therapeutic targeting, and explore recent advances in the development of therapeutic strategies for BC.

scholarly journals Dysregulated TET Family Genes and Aberrant 5mC Oxidation in Breast Cancer: Causes and Consequences

Cancers ◽  
2021 ◽  
Vol 13 (23) ◽  
pp. 6039
Author(s):  
Bo Xu ◽  
Hao Wang ◽  
Li Tan
Keyword(s):  
Breast Cancer ◽  
Dna Methylation ◽  
Embryonic Development ◽  
Cellular Differentiation ◽  
Epigenetic Modification ◽  
Current Understanding ◽  
Future Perspectives ◽  
Cancer Hallmarks ◽  
The Past

DNA methylation (5-methylcytosine, 5mC) was once viewed as a stable epigenetic modification until Rao and colleagues identified Ten-eleven translocation 1 (TET1) as the first 5mC dioxygenase in 2009. TET family genes (including TET1, TET2, and TET3) encode proteins that can catalyze 5mC oxidation and consequently modulate DNA methylation, not only regulating embryonic development and cellular differentiation, but also playing critical roles in various physiological and pathophysiological processes. Soon after the discovery of TET family 5mC dioxygenases, aberrant 5mC oxidation and dysregulation of TET family genes have been reported in breast cancer as well as other malignancies. The impacts of aberrant 5mC oxidation and dysregulated TET family genes on the different aspects (so-called cancer hallmarks) of breast cancer have also been extensively investigated in the past decade. In this review, we summarize current understanding of the causes and consequences of aberrant 5mC oxidation in the pathogenesis of breast cancer. The challenges and future perspectives of this field are also discussed.

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