scholarly journals Expression and clinical significance of the long non-coding RNA PVT1 in human gastric cancer

2014 ◽  
pp. 1625 ◽  
Author(s):  
Jian Ding ◽  
Dan Li ◽  
Minzhen Gong ◽  
Jinpo Wang ◽  
Xunru Huang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Clinical Significance ◽  
Human Gastric Cancer ◽  
Non Coding Rna ◽  
Long Non Coding Rna

scholarly journals Expression and clinical significance of long non-coding RNA HNF1A-AS1 in human gastric cancer

2015 ◽  
Vol 13 (1) ◽  
Author(s):  
Yuan Dang ◽  
Fenghua Lan ◽  
Xiaojuan Ouyang ◽  
Kai Wang ◽  
Youdong Lin ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Clinical Significance ◽  
Human Gastric Cancer ◽  
Non Coding Rna ◽  
Long Non Coding Rna

scholarly journals Long non-coding RNA expression profile in human gastric cancer and its clinical significances

2013 ◽  
Vol 11 (1) ◽  
pp. 225 ◽  
Author(s):  
Haojun Song ◽  
Weiliang Sun ◽  
Guoliang Ye ◽  
Xiaoyun Ding ◽  
Zhong Liu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Expression Profile ◽  
Rna Expression ◽  
Human Gastric Cancer ◽  
Non Coding Rna ◽  
Long Non Coding Rna

Reduced expression of the long non-coding RNA AI364715 in gastric cancer and its clinical significance

Tumor Biology ◽  
2015 ◽  
Vol 36 (10) ◽  
pp. 8041-8045 ◽  
Author(s):  
Shengqian Zhu ◽  
Jinqin Mao ◽  
Yongfu Shao ◽  
Fang Chen ◽  
Xiaoqin Zhu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Clinical Significance ◽  
Non Coding Rna ◽  
Long Non Coding Rna

The Variant rs145204276 of GAS5 is Associated with the Development and Prognosis of Gastric Cancer

2018 ◽  
Vol 27 (1) ◽  
pp. 19-24 ◽  
Author(s):  
Qianjun Li ◽  
Gang Ma ◽  
Huimin Guo ◽  
Suhua Sun ◽  
Ying Xu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Survival Rate ◽  
Cancer Progression ◽  
Regulatory Mechanism ◽  
Tumor Stage ◽  
Kaplan Meier ◽  
Non Coding Rna ◽  
Early Tumor ◽  
Long Non Coding Rna ◽  
Clinicopathological Variables

Background & Aims: Down-regulation of the growth arrest specific transcript 5 (GAS5) (long non-coding RNA) is associated with cell proliferation of gastric cancer (GC) and a poor prognosis. We aimed to investigate whether the variant rs145204276 of GAS5 is associated with the prognosis of GC in the Chinese population, and to unveil the regulatory mechanism underlying the GAS5 expression in GC tissues.Method: 1,253 GC patients and 1,354 healthy controls were included. The frequency of the genotype del/del and the allele del of rs145204276 were compared between the patients and the controls and between different subgroups of patients classified by clinicopathological variables. The overall survival rate was analyzed according to the Kaplan-Meier method using the log-rank test.Results: The frequency of genotype del/del was significantly lower in patients than in the controls (7.0% vs. 9.1%, p = 0.001). Kaplan-Meier analysis showed that genotype del/del was significantly associated with a higher survival rate (p = 0.01). Patients with late tumor stage were found to have a significantly lower rate of genotype del/del than those with an early tumor stage (4.9% vs. 8.8%, p = 0.01). Patients with UICC III and IV were found to have a significantly lower rate of genotype del/del than those with UICC I and II (5.3% vs. 8.1%, p = 0.02).Conclusion: The variant rs145204276 of GAS5 is associated with the development and prognosis of GC. The allele del of rs145204276 is associated with a remarkably lower incidence of cancer progression and metastasis.

Sign in / Sign up

Export Citation Format

Share Document