scholarly journals Role of urokinase plasminogen activator and plasminogen activator inhibitor mRNA expression as prognostic factors in molecular subtypes of breast cancer

2014 ◽  
pp. 2205 ◽  
Author(s):  
Isabell Witzel ◽  
Karin Milde-Langosch ◽  
Marcus Schmidt ◽  
Thomas Karn ◽  
Sven Becker ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Prognostic Factors ◽  
Mrna Expression ◽  
Plasminogen Activator ◽  
Molecular Subtypes ◽  
Plasminogen Activator Inhibitor ◽  
Urokinase Plasminogen Activator ◽  
Activator Inhibitor

Inhibitory Role of Plasminogen Activator Inhibitor-1 in Arterial Wound Healing and Neointima Formation

Circulation ◽  
1997 ◽  
Vol 96 (9) ◽  
pp. 3180-3191 ◽  
Author(s):  
Peter Carmeliet ◽  
Lieve Moons ◽  
Roger Lijnen ◽  
Stefaan Janssens ◽  
Florea Lupu ◽  
...  
Keyword(s):  
Wound Healing ◽  
Plasminogen Activator ◽  
Plasminogen Activator Inhibitor ◽  
Neointima Formation ◽  
Plasminogen Activator Inhibitor 1 ◽  
Inhibitory Role ◽  
Activator Inhibitor

Differential expression of plasminogen activators and their inhibitors in an organotypic skin coculture system

1993 ◽  
Vol 106 (1) ◽  
pp. 45-53 ◽  
Author(s):  
C.S. Chen ◽  
B. Lyons-Giordano ◽  
G.S. Lazarus ◽  
P.J. Jensen
Keyword(s):  
Plasminogen Activator ◽  
Plasminogen Activator Inhibitor ◽  
Urokinase Plasminogen Activator ◽  
Basal Cells ◽  
Type Plasminogen Activator ◽  
Inhibitor Type ◽  
Activator Inhibitor Type ◽  
Activator Inhibitor

Using immunohistochemistry and in situ hybridization, we have characterized the expression and localization of components of the plasminogen activator proteolytic cascade in an organotypic coculture system which consists of a “dermal” portion (human dermal fibroblasts throughout a collagen matrix) and a stratified, well-differentiated epidermal portion. Specifically, the following components were examined: the enzymes urokinase-type plasminogen activator and tissue-type plasminogen activator and their type 1 and type 2 inhibitors. Urokinase plasminogen activator mRNA and antigen were found predominantly in the least differentiated, basal keratinocytes; in some fields there was also faint deposition of antigen beneath the basal cells. The distribution of plasminogen activator inhibitor type 1 was similar to that of urokinase, except that inhibitor type 1 antigen deposition beneath the basal cells appeared more intense and uniform. In contrast to the results with urokinase plasminogen activator and inhibitor type 1, tissue plasminogen activator mRNA and antigen were localized focally in the suprabasal, i.e. more differentiated, keratinocytes. Plasminogen activator inhibitor type 2 mRNA and antigen were detected in most epidermal layers, but were more intense suprabasally and often spared the basal layer. These studies demonstrate that the same type of cell, i.e. the keratinocyte, can express different components of the plasminogen activator cascade depending on its state of differentiation. The change in expression of plasminogen activator cascade components with keratinocyte differentiation suggests distinct epidermal functions for these components, related to cell-matrix interaction and epidermal differentiation.

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