scholarly journals Cytoreductive surgery combined with hyperthermic intrapleural chemotherapy to treat thymoma or thymic carcinoma with pleural dissemination

2013 ◽  
pp. 517 ◽  
Author(s):  
Lei Yu ◽  
Yun Jing ◽  
Shan Ma ◽  
Fei Li ◽  
Yun-feng Zhang
Keyword(s):  
Cytoreductive Surgery ◽  
Thymic Carcinoma ◽  
Pleural Dissemination ◽  
Intrapleural Chemotherapy

scholarly journals Long-term survival in thymic carcinoma with postoperative pleural dissemination

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Toru Kimura ◽  
Masahiko Higashiyama ◽  
Keiichiro Honma ◽  
Harumi Nakamura ◽  
Tomohiro Maniwa ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Thymic Carcinoma ◽  
Postoperative Recurrence ◽  
Term Survival ◽  
Definitive Radiotherapy ◽  
Pleural Dissemination ◽  
Indolent Disease

Abstract Background We report a patient with thymic squamous cell carcinoma who underwent multiple rounds of surgical resection and definitive radiotherapy for both primary tumor and postoperative recurrence. However, the patient remains well and healthy 18 years after initial diagnosis. Since long-term survival after postoperative recurrence of thymic carcinoma is extremely rare, we also present her immunohistochemical staining results, which suggested indolent disease. Case presentation A 42-year-old woman with thymic squamous cell carcinoma underwent en bloc resection of the tumor and thymus gland. Pleural dissemination was noted in the right thoracic cavity 3, 10, and 16 years postoperatively. Where possible, the nodules were resected surgically: during the postoperative 3rd and 16th years. Definitive radiotherapy was administered for all nodules that could not be excised during the postoperative 3rd and 10th years. Disease-free survival is 25 months. Conclusions Local control of pleural dissemination may be beneficial in the treatment of postoperative recurrence of thymic carcinoma in limited cases of indolent disease.

Hyperthermic intrapleural chemotherapy combined with endostar by video-assisted thoracoscopic surgery for lung adenocarcinoma with pleural dissemination.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. e17542-e17542
Author(s):  
Lei Yu
Keyword(s):  
Pleural Effusion ◽  
Lung Adenocarcinoma ◽  
Thoracoscopic Surgery ◽  
Pleural Effusions ◽  
Term Survival ◽  
Pleural Dissemination ◽  
Malignant Pleural Effusions ◽  
Video Assisted ◽  
Intrapleural Chemotherapy

e17542 Background: Patients with lung adenocarcinoma and malignant pleural effusions have limited life expectancy. The treatment of lung adenocarcinoma with malignant pleural effusions remains controversial. The purpose of our study is to evaluate the use of video-assisted thoracoscopy to perform hyperthermic intrapleural chemotherapy combined with Endostar (recombinant human endostatin) for disseminated pleural adenocarcinoma. Methods: From 2007 to 2010, there were 46 patients with lung adenocarcinoma and pleural dissemination undergoing thoracoscopic surgery and intrathoracic hyperthermic perfusion with chemotherapy in combination of Endostar. After thoracoscopic surgery, the hyperthermic perfusion system was set up for hyperthermic intrapleural chemotherapy. The thoracic cavity was perfused at a speed of approximately 1.8-2.3 L/min with 0.9% normal saline (4-5L), containing cisplatinum (100 mg). The intrathoracic temperature remained between 42°C to 43°C. This process of perfusion lasted for 1 hours. Following this, 2L of 0.45% saline with Endostar (30 mg) at a temperature of 30 °C was put into the pleural cavity and kept for 30 min. Results: There were no peri-operative deaths. During the hyperthermic perfusion, patient's core temperature varied from 36.3ºC and 39.3ºC and pulse from 59 beats/m and 126 beats/m. Intraoperative sinus tachycardia occurred in 2 elderly cases. No hematologic toxicity and nephrotoxicity was observed within one week after surgery. Postoperative pneumonia occurred in 1 elderly case. The median survival time was 21 months. During the follow-up period, only one patient suffered from continuing pleural effusion due to atelectasis, one elderly patient died of heart failure one year after surgery and the remaining patients were completely free from pleural effusion during the last follow-up. Conclusions: Hyperthermic intrapleural chemotherapy combined with Endostar by thoracoscopic surgery offers a safe and effective treatment for lung adenocarcinoma with pleural dissemination. It may be time-consuming, but beneficial and may have an encouraging impact on its long-term survival.

Cytoreductive surgery and hyperthermic intrapleural chemotherapy for malignant pleural diseases: preliminary experience

2015 ◽  
Vol 11 (2s) ◽  
pp. 47-52 ◽  
Author(s):  
Marcello Migliore ◽  
Damiano Calvo ◽  
Alessandra Criscione ◽  
Cristina Viola ◽  
Giuseppe Privitera ◽  
...  
Keyword(s):  
Cytoreductive Surgery ◽  
Pleural Diseases ◽  
Intrapleural Chemotherapy

Hyperthermic intraoperative intrapleural chemotherapy and surgical cytoreduction as part of multimodal treatment of malignant pleural mesothelioma – case report

2020 ◽  
Vol 99 (10) ◽  
Keyword(s):  
Malignant Pleural Mesothelioma ◽  
Cytoreductive Surgery ◽  
Multimodal Treatment ◽  
Multimodal Therapy ◽  
University Hospital ◽  
Extrapleural Pneumonectomy ◽  
Pleural Mesothelioma ◽  
Therapeutic Modalities ◽  
Hyperthermic Chemotherapy ◽  
Intrapleural Chemotherapy

Malignant pleural mesothelioma is one of the most aggressive malignancies with a very poor prognosis. Multimodal treatment consisting of three modalities – chemotherapy, radiotherapy and cytoreductive surgery is optimal. The use of new therapeutic modalities, such as hyperthermic intraoperative intrapleural chemotherapy or photodynamic therapy can improve the current results of mesothelioma treatment. Combined hyperthermic intraoperative chemotherapy and cytoreductive surgery as part of multimodal therapy of malignant mesothelioma has been used since 2017 at the 1st Department of Surgery of University Hospital Olomouc. The authors report the case of a 47-year-old man with malignant epithelioid mesothelioma of the left pleural cavity. Following neoadjuvant chemotherapy, this patient underwent extrapleural pneumonectomy with intraoperative intracavitary hyperthermic chemotherapy. The postoperative period was complicated by circulatory instability and later by tension fluidothorax with signs of heart failure. Currently, 8 months have elapsed from the surgery and the patient remains without any signs of recurrence.

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