scholarly journals Potential Role of Pleural Fluid Cytokine Profile in Myelomatous Pleural Effusions

2021 ◽  
Vol Volume 14 ◽  
pp. 4545-4550
Author(s):  
Junhui Xu ◽  
Liang Gao ◽  
Miao Yan ◽  
Bingjie Wang ◽  
Zheng-yang Song ◽  
...  
Keyword(s):  
Pleural Fluid ◽  
Potential Role ◽  
Cytokine Profile ◽  
Pleural Effusions

The role of pleural fluid thiol/disulphide homoeostasis in the differentiation between transudative and exudative pleural effusions

2021 ◽  
Author(s):  
Nazli Gormeli Kurt ◽  
Servan Gokhan ◽  
Ozcan Erel ◽  
Celal Gunes ◽  
Ahmet Fatih Kahraman ◽  
...  
Keyword(s):  
Pleural Fluid ◽  
Pleural Effusions

scholarly journals The Role of Cytokine profile detection in Myelomatous pleural effusions

2021 ◽  
Author(s):  
Junhui Xu ◽  
Liang Gao ◽  
Miao Yan ◽  
Bingjie Wang ◽  
Zhengyang Song ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Pleural Effusion ◽  
Cytokine Profile ◽  
Pleural Effusions ◽  
Case Presentation ◽  
Cytokine Detection ◽  
Tnf Α ◽  
Tumor Load ◽  
Poor Outcomes

Abstract Background: Myelomatous pleural effusion (MPE), as a presentation of extramedullary infiltration of multiple myeloma (MM), is rare and associated with poor outcomes without comparatively effective treatment now. The value of the cytokine detection in pleural effusions to MPE has not been reported at present. Case presentation: We herein report a case of refractory and relapsed multiple myeloma which developed bilateral MPE due to disease progression caused by intolerance to various chemotherapy regimens. The cytomorphology and flow cytometry is adopted in the diagnosis confirmation. The chemotherapy containing immunomodulators combined with thoracic catheterization drainage is applied to the patient, showing a certain therapeutic effect. During the course of disease, the changes of cytokine profile in pleural effusion were monitored by Biolegend CBA technology, revealing that the cytokines such as IL-6 and IL-10 related to the tumor load in pleural effusion decreased with the improvement of the disease, while IL-2, IL-4, IL-17A, TNF - α, INF - γ, granzyme A, Granzyme B, perforin and granulysin increased with the improvement of the disease. Conclusions: There is a prospect that the cytokines level in pleural effusion becomes an indication to evaluate treatment response of MPE, and in the light of our finding, immunomodulators, IL-2 and INF - γ may be utilized in treating patients suffering MPE.

scholarly journals Potential role of human visceral pleura in pleural fluid turnover

2006 ◽  
Vol 119 (3) ◽  
pp. 250-254 ◽  
Author(s):  
Zhan-cheng GAO ◽  
Pei-li XUE ◽  
Yang ZHANG ◽  
Dan-hua SHEN ◽  
Jun WANG ◽  
...  
Keyword(s):  
Pleural Fluid ◽  
Potential Role ◽  
Visceral Pleura

scholarly journals Pleural tuberculosis

2016 ◽  
Vol 65 (1) ◽  
Author(s):  
B. Chakrabarti ◽  
P.D.O. Davies
Keyword(s):  
Pleural Fluid ◽  
Diagnostic Yield ◽  
Western World ◽  
Pleural Effusions ◽  
Pleural Biopsy ◽  
Biopsy Specimens ◽  
Tuberculous Pleurisy ◽  
The Impact ◽  
Antituberculous Chemotherapy

Pleural effusions in tuberculosis are commonly seen in young adults as an immunological phenomenon occurring soon after primary infection. However, the epidemiology and demographics of tuberculous pleurisy are changing due to the impact of HIV co-infection and the increasing number of pleural effusions seen as part of re-activation disease. Pleural biopsy for histology and culture is the mainstay of diagnosis with closed needle biopsy adequate in the majority of cases. Techniques such as PCR of biopsy specimens and the role of pleural fluid ADA are still being evaluated as a diagnostic aid. Tuberculous empyema is less commonly seen in the western world and the diagnostic yield from pleural fluid here is greater than in “primary” effusions. Treatment with appropriate antituberculous chemotherapy is generally successful though there is currently insufficient evidence to recommend the routine use of corticosteroids in this condition.

scholarly journals Role of Combined Pleural Fluid Cholesterol and Total Protein in Differentiation of Exudates and Transudates

2020 ◽  
Vol 3 (1) ◽  
pp. 282-285
Author(s):  
Anupam Bista ◽  
Suman Thapa ◽  
Prasant Subedi ◽  
Kiran Manandhar
Keyword(s):  
Pleural Fluid ◽  
Standard Method ◽  
Total Protein ◽  
Gold Standard ◽  
Pleural Effusions

Introduction: Light's criteria had been the standard method for distinguishing exudative and transudative pleural effusions which misidentify 15-20% of transudates as exudates. This study aims to find out the role of combined pleural fluid cholesterol and total protein in distinguishing exudative from transudative pleural effusions and its applicability in Nepalese populations. Materials and Methods: Patients with pleural effusions were enrolled for the study. The combined pleural fluid cholesterol and total protein were compared with Light’s criteria and also compared with the diagnosis on discharge to find out their usefulness in categorizing the pleural effusions. Results: A total of 81 patients enrolled in the study, 42 (51.9%) were male. Based on Light’s criteria, 88.8% pleural effusions were found to be exudates and 11.1% were found to be transudates. Within the criteria, Light’s criteria categorized more pleural fluids as exudates than the diagnosis on discharge. Based on pleural fluid cholesterol >60mg/dL and protein >3g/dL for the classification of exudative and transudative pleural fluid, 62.9% out of 81 samples felled under the exudates and 37.03% pleural effusions under transudates with the sensitivity 87.9% and specificity 100%. Conclusions: Though Light’s criteria remain the gold standard to differentiate transudates and exudates, combined pleural fluid cholesterol and total protein give nearly comparable results without the need for simultaneous blood investigations.

scholarly journals Role of Pleural Fluid Albumin in the Exudative Pleural Effusions

CHEST Journal ◽  
2010 ◽  
Vol 138 (4) ◽  
pp. 341A
Author(s):  
Seok-Chul Yang ◽  
Chang-Hoon Lee ◽  
Ho Il Yoon ◽  
Sang-Min Lee ◽  
Jae-Joon Yim ◽  
...  
Keyword(s):  
Pleural Fluid ◽  
Pleural Effusions

scholarly journals Diagnosis dan tatalaksana terbaru penyakit pleura

2020 ◽  
Vol 2 (1) ◽  
pp. 69-78
Author(s):  
Ni Putu Nita Pranita
Keyword(s):  
Pleural Effusion ◽  
Pleural Fluid ◽  
Malignant Pleural Effusion ◽  
Bronchopleural Fistula ◽  
Disease Process ◽  
Standard Of Care ◽  
Underlying Disease ◽  
Pleural Disease ◽  
Pleural Effusions

Pleural effusion is a common problem. Pleural effusion developed as a sequel to the underlying disease process, including pressure/volume imbalance, infection, and malignancy. In addition to pleural effusion, persistent air leak after surgery and bronchopleural fistula remain a challenge by a physician. An understanding of the pleural disease, including its diagnosis and management, has made an extraordinary step. The introduction of molecular detection of organism-specific infections, risk stratification, and improvement in the non-surgical treatment of patients with pleural infection are all within reach and maybe the standard of care shortly. This article discusses the role of existing techniques, and some of the more recent ones, which are now available for establishing the diagnosis of pleural disease. The initial approach to diagnosis usually begins by distinguishing between transudates and exudates, based on the concentration of protein and lactate dehydrogenase (LDH) in pleural fluid. The exact role of amylase and LDH can provide additional information towards the differential diagnosis of various exudative pleural effusions. With newer cytochemical staining techniques in pleural fluid, diagnostic results of malignant pleural effusion can increase by up to 80%. Ultrasound (US) and thoracic computed tomographic (CT) scans have further improved the diagnosis of undiagnosed pleural effusion. The reappearance of thoracoscopy as the latest diagnostic and therapeutic tool (e.g., Pleurodesis) for undiagnosed or recurrent pleural effusions. Management of malignant pleural effusion continues to develop with the introduction of tunneled pleural catheters and chemical pleurodesis procedures. Advances in the diagnostic and therapeutic evaluation of pleural disease and what appears to be an increasing multidisciplinary interest in a doctor managing patients with pleural disease.

scholarly journals Investigating unilateral pleural effusions: the role of cytology

2018 ◽  
Vol 52 (5) ◽  
pp. 1801254 ◽  
Author(s):  
David T. Arnold ◽  
Duneesha De Fonseka ◽  
Siobhan Perry ◽  
Anna Morley ◽  
John E. Harvey ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Pleural Fluid ◽  
Final Diagnosis ◽  
Clinical Suspicion ◽  
Cytological Analysis ◽  
Haematological Malignancies ◽  
Pleural Effusions ◽  
Large Prospective Cohort ◽  
Fluid Cytology

The vast majority of undiagnosed unilateral pleural effusions have fluid sent for cytological analysis. Despite widespread use, there is uncertainty about its sensitivity to diagnose malignant pleural effusions (MPEs). Our aim was to ascertain the utility of cytology using a large prospective cohort.Consecutive patients presenting with an undiagnosed unilateral pleural effusion were recruited to this UK-based study. All had pleural fluid sent for cytological analysis. Cytological sensitivity was based on the final diagnosis at 12 months, confirmed by two consultants.Over 8 years, 921 patients were recruited, of which 515 had a MPE. Overall sensitivity of fluid cytology to diagnose malignancy was 46% (95% CI 42–58%). There was variation in sensitivity depending on cancer primary, with mesothelioma (6%) and haematological malignancies (40%) being significantly lower than adenocarcinomas (79%). MPEs secondary to ovarian cancer had high pick-up rates (95%). In asbestos-exposed males with exudative effusions, the risk of MPE was 60%, but cytological sensitivity was 11%.This is the largest prospective study of pleural fluid cytology and informs discussions with patients about the likely requirement for investigations following thoracentesis. In patients presenting with a clinical suspicion of mesothelioma, cytological sensitivity is low, so more definitive investigations could be performed sooner.

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