scholarly journals A Comparative Study of Self-Expandable Metallic Stent Combined with Double 125I Seeds Strands or Single 125I Seeds Strand in the Treatment of Advanced Perihilar Cholangiocarcinoma with Malignant Obstructive Jaundice

2021 ◽  
Vol Volume 14 ◽  
pp. 4077-4086
Author(s):  
Zhaonan Li ◽  
Dechao Jiao ◽  
Xinwei Han ◽  
Zaoqu Liu
2020 ◽  
Author(s):  
Zhaonan Li ◽  
Dechao Jiao ◽  
Xinwei Han ◽  
Xueliang Zhou ◽  
Yahua Li

Abstract Background The placement of 125I seeds was a safe method for treating cholangiocarcinoma .The purpose of this study was to compare a novel brachytherapy biliary drainage catheter (BBDC) with an Iodine-125 (125I) seed strand after self-expandable metallic stent(SEMs) implantation in terms of safety and efficacy, as treatments for patients with cholangiocarcinoma of malignant obstructive jaundice (MOJ). Methods From September 2016 to December 2018, We retrospectively enrolled patients with biliary stent implantation after receiving either BBDC loaded with 125I seeds (double-strands irradiation group) or an 125I seed strand treatment (single-strand irradiation group, control group). The outcomes were analyzed regarding the relief of obstructive jaundice, interventional-related complications, stent patency and survival time. ResultsThe success rate of interventional therapy in both groups was 100% and all patients with MOJ were alleviated . The overall complication rates of BBDC group and control group were 23.1% (9 / 39) and 26.5% (9/ 34), respectively (P > 0.05). The median and mean overall stent patency of the BBDC group and the control group were (207 days versus 180 days, 204.212 days versus 186.278 days, p = 0.043). The median and mean overall survivals in the BBDC group were higher than those in the control group (245 days versus 212 days, 244.883 days versus 221.844 days, p = 0.030). ConclusionsThis interim analysis showed that BBDC (double-stranded irradiation) can prolong the stent patency time compared with 125I seed strand treatment (single-stranded irradiation) and had the advantage of reducing jaundice, which seemed to extend survival period.


2001 ◽  
Vol 14 (3-4) ◽  
pp. 208-211 ◽  
Author(s):  
T. Aoki ◽  
Y. Osaka ◽  
Y. Takagi ◽  
R. Okada ◽  
M. Shinohara ◽  
...  

1998 ◽  
Vol 33 (6) ◽  
pp. 886-890 ◽  
Author(s):  
Morihiro Okazaki ◽  
Akifumi Mizuta ◽  
Noboru Hamada ◽  
Nozomu Kawamura ◽  
Kazushi Nakao ◽  
...  

1996 ◽  
Vol 37 (1P1) ◽  
pp. 259-266 ◽  
Author(s):  
S. Men ◽  
B. Hekimoğlu ◽  
H. Kaderoğlu ◽  
A. Pinar ◽  
I. Conkbayir ◽  
...  

Purpose: The aim of this study was to analyze the clinical efficacy of metal stents in the palliation of malignant obstructive jaundice. Material and Methods: Fifty patients with malignant biliary obstruction were palliated by means of drainage with a metallic self-expandable stent (Wallstent). Nineteen patients had pancreatic carcinoma, 22 cholangiocarcinoma, 4 hepatocellular carcinoma, and the remaining 5 metastatic carcinoma from a variety of primary sites. The obstruction was at the level of the liver hilum in 19 cases, in the middle common bile duct in 11, and in the lower common bile duct in 20. Results: The patients were followed over a period of 1–17 months. A total of 36 patients (72%) died; 14 (28%) survived. The mean observation time for the whole group of 50 patients was 3.3 months. The 30-day mortality rate was 14% (7 patients). Short-term complications occurred in 6 patients (12%). Long-term complications included stent occlusion requiring a 2nd intervention in 2 patients (4%), and cholangitis in 2 patients (4%). Excellent palliation was achieved in most of the patients. No stent migration was observed. Conclusion: The metallic stent provides good palliative drainage, and the percutaneous insertion of metallic stents is well tolerated by the patients. The procedure is simple and safe to use and can be executed in one stage. The one-stage procedure, compared to the 2-stage procedure, may reduce hospital stays.


2021 ◽  
Vol 9 (35) ◽  
pp. 10979-10993
Author(s):  
Wei-Yue Chen ◽  
Chun-Li Kong ◽  
Miao-Miao Meng ◽  
Wei-Qian Chen ◽  
Li-Yun Zheng ◽  
...  

2021 ◽  
Author(s):  
Hiroshi Mori ◽  
Hiroki Kawashima ◽  
Eizaburo Ohno ◽  
Takuya Ishikawa ◽  
Yasuyuki Mizutani ◽  
...  

Abstract BackgroundThere is a need for a more tolerable preoperative biliary drainage (PBD) method for perihilar cholangiocarcinoma (PHCC). In recent years, inside stents (ISs) have attracted attention as a less suffering PBD method. Few studies have compared IS with a fully covered self-expandable metallic stent (FCSEMS) as PBD for resectable PHCC. The aim of this study is to compare them.MethodsThis study involved 87 consecutive patients (IS: 51, FCSEMS: 36). The recurrent biliary obstruction (RBO) rate until undergoing surgery or being diagnosed as unresectable, time to RBO, factors related to RBO, incidence of adverse events related to endoscopic retrograde cholangiography and postoperative complications associated with each stent were evaluated retrospectively.ResultsThere was no significant difference between the two groups in the incidence of adverse events after stent insertion. The mean (s.d.) time to RBO was 40.0 (28.1) days in the IS group and 52.0 (45.5) days in the FCSEMS group, with no significant difference (P=0.384). A total of 7/51 patients in the IS group and 3/36 patients in the FCSEMS group developed RBO. The only risk factor for RBO was bile duct obstruction of the future excisional liver lobe(s) due to stenting (HR 0.033, P=0.006) in the FCSEMS group, but risk factors could not be indicated in the IS group. Regarding postoperative complications, there was no significant difference in the incidence of bile leakage or liver failure. In contrast, pancreatic fistula was significantly more common in the FCSEMS group (13/24 patients) than in the IS group (3/28 patients) (P=0.001), especially in patients who did not undergo pancreatectomy (P=0.001).ConclusionsAs PBD for PHCC, both IS and FCSEMS achieved low RBO rates. In contrast, the incidence of postoperative pancreatic fistula was higher with FCSEMS. Thus, IS, which can be inserted easily, is considered an optimal approach as PBD for resectable PHCC.clinical trial registration number: UMIN000025631


2018 ◽  
Vol 71 (3) ◽  
pp. 124
Author(s):  
Jihye Kim ◽  
Yang Won Min ◽  
Hyuk Lee ◽  
Byung-Hoon Min ◽  
Joon Haeng Lee ◽  
...  

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