scholarly journals Expression of p16, p53, and TLR9 in HPV-Associated Head and Neck Squamous Cell Carcinoma: Clinicopathological Correlations and Potential Prognostic Significance

2021 ◽  
Vol Volume 14 ◽  
pp. 867-877
Author(s):  
Shu Wang ◽  
Xibing Zhuang ◽  
Caixia Gao ◽  
Tiankui Qiao
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Prognostic Significance ◽  
Neck Squamous Cell Carcinoma ◽  
Clinicopathological Correlations

scholarly journals Integrated Analysis Reveals ENDOU as a Biomarker in Head and Neck Squamous Cell Carcinoma Progression

2021 ◽  
Vol 10 ◽  
Author(s):  
Chengzhi Xu ◽  
Yunbin Zhang ◽  
Yupeng Shen ◽  
Yong Shi ◽  
Ming Zhang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Prognostic Significance ◽  
Neck Squamous Cell Carcinoma ◽  
Integrated Analysis ◽  
Pathway Enrichment Analysis ◽  
And Migration ◽  
Proliferation And Migration

BackgroundHead and neck squamous cell carcinoma (HNSCC) is a leading cancer with high morbidity and mortality worldwide. The aim is to identify genes with clinical significance by integrated bioinformatics analysis and investigate their function in HNSCC.MethodsWe downloaded and analyzed two gene expression datasets of GSE6631 and GSE107591 to screen differentially expressed genes (DEGs) in HNSCC. Common DEGs were functionally analyzed by Gene ontology and KEGG pathway enrichment analysis. Protein-protein interaction (PPI) network was constructed with STRING database and Cytoscape. ENDOU was overexpressed in FaDu and Cal-27 cell lines, and cell proliferation and migration capability were evaluated with MTT, scratch and transwell assay. The prognostic performance of ENDOU and expression correlation with tumor infiltrates in HNSCC were validated with TCGA HNSCC datasets.ResultsNinety-eight genes shared common differential expression in both datasets, with core functions like extracellular matrix organization significantly enriched. 15 genes showed prognostic significance, and COBL and ENDOU serve as independent survival markers in HNSCC. In-vitro ENDOU overexpression inhibited FaDu and Cal-27 cells proliferation and migration, indicating its tumor-suppressing role in HNSCC progression. GSEA analysis indicated ENDOU down-stream pathways like DNA replication, mismatch repair, cell cycle and IL-17 signaling pathway. ENDOU showed relative lower expression in HNSCC, especially HPV-positive HNSCC samples. At last, ENDOU showed negative correlation with tumor purity and tumor infiltrating macrophages, especially M2 macrophages.ConclusionThis study identified ENDOU as a biomarker with prognostic significance in HNSCC progression.

scholarly journals Prognostic Significance of Truncating TP53 Mutations in Head and Neck Squamous Cell Carcinoma

2011 ◽  
Vol 17 (11) ◽  
pp. 3733-3741 ◽  
Author(s):  
Marlon Lindenbergh-van der Plas ◽  
Ruud H. Brakenhoff ◽  
Dirk J. Kuik ◽  
Marijke Buijze ◽  
Elisabeth Bloemena ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Prognostic Significance ◽  
Neck Squamous Cell Carcinoma ◽  
Tp53 Mutations

The prognostic significance of Notch 1 intracellular domain nuclear levels in head and neck squamous cell carcinoma.

2016 ◽  
Vol 34 (15_suppl) ◽  
pp. 6061-6061
Author(s):  
Theodoros Rampias ◽  
Margaritis Avgeris ◽  
Maria Vassilakopoulou ◽  
Veronique Neumeister ◽  
Nikos Haralambakis ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Prognostic Significance ◽  
Neck Squamous Cell Carcinoma ◽  
Notch 1 ◽  
Intracellular Domain ◽  
Nuclear Levels

Prognostic significance of cyclooxygenase-2 pathway and angiogenesis in head and neck squamous cell carcinoma

2002 ◽  
Vol 33 (7) ◽  
pp. 708-714 ◽  
Author(s):  
Oreste Gallo ◽  
Emanuela Masini ◽  
Benedetta Bianchi ◽  
Luca Bruschini ◽  
Milena Paglierani ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Prognostic Significance ◽  
Cyclooxygenase 2 ◽  
Neck Squamous Cell Carcinoma

Molecular Markers in Head and Neck Squamous Cell Carcinoma: Their Biological Function and Prognostic Significance

2001 ◽  
Vol 110 (3) ◽  
pp. 221-228 ◽  
Author(s):  
Benjamin D. Smith ◽  
Bruce G. Haffty ◽  
Clarence T. Sasaki
Keyword(s):  
Squamous Cell Carcinoma ◽  
Molecular Markers ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Biological Function ◽  
Prognostic Significance ◽  
Growth Factor Receptor ◽  
Neck Squamous Cell Carcinoma ◽  
Increased Risk

Head and neck squamous cell carcinoma affects more than 500,000 people worldwide each year. Despite optimal treatment with surgery, irradiation, and chemotherapy, disease recurrence and progression remains a common and challenging oncological problem. Recently, interest has developed in identifying novel molecular markers that allow identification of those patients at increased risk for locoregional recurrence and death. This article reviews several such molecular markers studied in head and neck cancer, including p53, angiogenesis-related markers, cyclin D1, and epidermal growth factor receptor. The biological function of these markers and the potential clinical implications are discussed. The purpose of this review is to update the otolaryngologist on a rapidly emerging segment of applied translational research in our field.

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