scholarly journals Peripheral Blood Leukocyte N6-methyladenosine is a Noninvasive Biomarker for Non-small-cell Lung Carcinoma

2020 ◽  
Vol Volume 13 ◽  
pp. 11913-11921
Author(s):  
Yuqing Pei ◽  
Xiaoying Lou ◽  
Kexin Li ◽  
Xiaotian Xu ◽  
Ye Guo ◽  
...  
Keyword(s):  
Lung Carcinoma ◽  
Peripheral Blood ◽  
Small Cell Lung Carcinoma ◽  
Peripheral Blood Leukocyte ◽  
Small Cell ◽  
Small Cell Lung ◽  
Cell Lung Carcinoma ◽  
Noninvasive Biomarker ◽  
Blood Leukocyte

Detection of tumor specific gene expression in bone marrow and peripheral blood from patients with small cell lung carcinoma

Cancer ◽  
2003 ◽  
Vol 97 (4) ◽  
pp. 1057-1062 ◽  
Author(s):  
Masato Shingyoji ◽  
Yuichi Takiguchi ◽  
Reiko Watanabe ◽  
Kenzo Hiroshima ◽  
Ken Motoori ◽  
...  
Keyword(s):  
Gene Expression ◽  
Bone Marrow ◽  
Lung Carcinoma ◽  
Peripheral Blood ◽  
Small Cell Lung Carcinoma ◽  
Small Cell ◽  
Specific Gene ◽  
Small Cell Lung ◽  
Cell Lung Carcinoma ◽  
Specific Gene Expression

scholarly journals Effects of LncRNA MEG3 on immunity and autophagy of non-small cell lung carcinoma through IDO signaling pathway

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Chuanqiang Wang ◽  
Xiangbo Tao ◽  
Jungong Wei
Keyword(s):  
Signaling Pathway ◽  
Lung Tissue ◽  
Lung Carcinoma ◽  
Peripheral Blood ◽  
Small Cell Lung Carcinoma ◽  
Small Cell ◽  
Small Cell Lung ◽  
Cell Lung Carcinoma ◽  
Diagnostic Values ◽  
Nsclc Patients

Abstract Background The study was done to investigate the effect of LncRNA MEG3 on the immunity and autophagy of non-small cell lung carcinoma through the IDO signaling pathway. Methods A total of 78 cases of early NSCLC patients (research group; RG) and 69 cases of health controls (control group; CG) during the same time were included. The contents of LncRNA MEG3 and miR-543 in peripheral blood and tissues and their diagnostic values for NSCLC were detected. The relationship between LncRNA MEG3 and miR-543 and their posttreatment contents and influence on the prognosis of NSCLC patients were tested. The expression of LncRNA MEG3, miR-543, and IDO (IDO1, IDO2, and TDO proteins) in the lung tissue of rats and the immune function in the CG and the RG were detected. The effects of LncRNA MEG3 and miR-543 on the biological behavior of NSCLC cells were determined. The role of LncRNA MEG3, miR-543, and IDO in NSCLC was verified. Results LncRNA MEG3 was low in peripheral blood and tissues, while miR-543 was high (P < 0.05); both had good diagnostic values for NSCLC (P < 0.05). LncRNA MEG3 had a negative correlation with miR-543 (P < 0.05) and influenced the prognosis of NSCLC patients (P < 0.05). LncRNA MEG3 in the lung tissue of rats using IDO inhibitor was elevated compared with that of lung carcinoma model rats (P < 0.05). The level of miR-543 was declined compared with that of lung carcinoma model rats (P < 0.05). The levels of IDO1, IDO2, and TDO proteins were evidently declined compared with those of lung carcinoma model rats (P < 0.05). Compared with lung carcinoma model rats, CD3+, CD4+, and CD4+/CD8+ of IDO inhibitor rats were elevated, while CD8+ was declined (P < 0.05). Cell proliferation and invasion ability and IDO1, IDO2, TDO, Beclin-1, and LC3-II proteins were declined in the sh-LncRNA MEG3 group (P < 0.05), while those in the mimics-miR-543 group were evidently elevated (P < 0.05). However, the double luciferase activity detection and RIP experiment confirmed that there was targeted regulation among them (P < 0.05). Conclusion MEG3 has low expression in NSCLC and affects the immunity and autophagy of NSCLC cells via regulating the miR-543/IDO signaling pathway, which is effective for the treatment of NSCLC.

scholarly journals Two Molecular Markers of Early Non-Small Cell Lung Carcinoma Based on Gene Expression in Peripheral Blood

2017 ◽  
Vol 07 (03) ◽  
pp. 91-102
Author(s):  
Naghmeh Bahrami ◽  
Hamidreza Jamaati ◽  
Jalal Heshmat Nia ◽  
Payam Tabarsi ◽  
Atefeh Fakharian ◽  
...  
Keyword(s):  
Gene Expression ◽  
Molecular Markers ◽  
Lung Carcinoma ◽  
Peripheral Blood ◽  
Small Cell Lung Carcinoma ◽  
Small Cell ◽  
Small Cell Lung ◽  
Cell Lung Carcinoma

Clinical Features And Outcomes Of Patients With Small Cell Lung Carcinoma; Retrospective Analysis

2015 ◽  
Vol 3 (2) ◽  
pp. 47 ◽  
Author(s):  
Duygu Unalmış ◽  
Zehra Yasar ◽  
Melih Buyuksirin ◽  
Gulru Polat ◽  
Fatma Demirci Ucsular ◽  
...  
Keyword(s):  
Retrospective Analysis ◽  
Clinical Features ◽  
Lung Carcinoma ◽  
Small Cell Lung Carcinoma ◽  
Small Cell ◽  
Small Cell Lung ◽  
Cell Lung Carcinoma
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