scholarly journals The Long Non-Coding RNA SBF2-AS1 Exerts Oncogenic Functions in Gastric Cancer by Targeting the miR-302b-3p/E2F Transcription Factor 3 Axis [Retraction]

2020 ◽  
Vol Volume 13 ◽  
pp. 2523-2524
Author(s):  
Chaojie Liang ◽  
Chaosen Yue ◽  
Chaowei Liang ◽  
Hua Ge ◽  
Zhigang Wei ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Transcription Factor ◽  
Non Coding Rna ◽  
E2f Transcription Factor ◽  
Long Non Coding Rna ◽  
Transcription Factor 3

scholarly journals Regulation of E2F Transcription Factor 3 by microRNA-152 Modulates Gastric Cancer Invasion and Metastasis

2020 ◽  
Vol Volume 12 ◽  
pp. 1187-1197 ◽  
Author(s):  
Liangliang Shi ◽  
Hao Zhu ◽  
Yonghua Shen ◽  
Xiaotan Dou ◽  
Huimin Guo ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Transcription Factor ◽  
Cancer Invasion ◽  
Invasion And Metastasis ◽  
E2f Transcription Factor ◽  
Transcription Factor 3

Long non-coding RNA LINC00982 up-regulates CTSF expression to inhibit gastric cancer progression via the transcription factor HEY1

2020 ◽  
Author(s):  
Lei Zheng ◽  
Junli Cao ◽  
Lijie Liu ◽  
Hongmei Xu ◽  
Lanlan Chen ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Transcription Factor ◽  
Cancer Cells ◽  
Molecular Mechanisms ◽  
Luciferase Assay ◽  
Migration And Invasion ◽  
Gastric Cancer Cells ◽  
Non Coding Rna ◽  
Cancer Tissues ◽  
Long Non Coding Rna

Upregulating the expression of long non-coding RNA LINC00982 controlled cell proliferation in gastric cancer, but the regulatory molecular mechanisms are yet to be expounded. We here aimed to elaborate how LINC00982 regulated the malignancy of gastric cancer cells. RT-qPCR and Western blot analysis were used to detect the expression of LINC00982 and CTSF in gastric cancer tissues and cells. Modulatory effect of LINC00982 on gastric cancer cells was assessed by CCK-8, colony formation, Transwell migration and invasion assays. The relationship between LINC00982, HEY1 and CTSF was examined by RIP, luciferase assay, and ChIP, and their interaction in the regulation of gastric cancer cellular functions was analyzed by performing gain-of-function and rescue assays. The nude mouse model of tumor formation was developed to examine the effects of LINC00982 on tumorigenesis. LINC00982 was lowly expressed in gastric cancer tissues, while its overexpression impaired the proliferative, migratory and invasive properties of gastric cancer cells. Furthermore, LINC00982 could bind to transcription factor HEY1 and inhibited its expression. Through blocking the binding of HEY1 to CTSF promoter. LINC00982 promoted the expression of CTSF. Overexpression of HEY1 or inhibition of CTSF could reverse the anti-tumor effects of LINC00982 on gastric cancer, which were further demonstrated in vivo. Taken together, LINC00982 acted as a tumor suppressor in gastric cancer, which is therefore suggested to be a potential anti-tumor target for gastric cancer.

The Variant rs145204276 of GAS5 is Associated with the Development and Prognosis of Gastric Cancer

2018 ◽  
Vol 27 (1) ◽  
pp. 19-24 ◽  
Author(s):  
Qianjun Li ◽  
Gang Ma ◽  
Huimin Guo ◽  
Suhua Sun ◽  
Ying Xu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Survival Rate ◽  
Cancer Progression ◽  
Regulatory Mechanism ◽  
Tumor Stage ◽  
Kaplan Meier ◽  
Non Coding Rna ◽  
Early Tumor ◽  
Long Non Coding Rna ◽  
Clinicopathological Variables

Background & Aims: Down-regulation of the growth arrest specific transcript 5 (GAS5) (long non-coding RNA) is associated with cell proliferation of gastric cancer (GC) and a poor prognosis. We aimed to investigate whether the variant rs145204276 of GAS5 is associated with the prognosis of GC in the Chinese population, and to unveil the regulatory mechanism underlying the GAS5 expression in GC tissues.Method: 1,253 GC patients and 1,354 healthy controls were included. The frequency of the genotype del/del and the allele del of rs145204276 were compared between the patients and the controls and between different subgroups of patients classified by clinicopathological variables. The overall survival rate was analyzed according to the Kaplan-Meier method using the log-rank test.Results: The frequency of genotype del/del was significantly lower in patients than in the controls (7.0% vs. 9.1%, p = 0.001). Kaplan-Meier analysis showed that genotype del/del was significantly associated with a higher survival rate (p = 0.01). Patients with late tumor stage were found to have a significantly lower rate of genotype del/del than those with an early tumor stage (4.9% vs. 8.8%, p = 0.01). Patients with UICC III and IV were found to have a significantly lower rate of genotype del/del than those with UICC I and II (5.3% vs. 8.1%, p = 0.02).Conclusion: The variant rs145204276 of GAS5 is associated with the development and prognosis of GC. The allele del of rs145204276 is associated with a remarkably lower incidence of cancer progression and metastasis.

scholarly journals Retraction: Long non-coding RNA XIST promotes proliferation, autophagy and inhibits apoptosis by regulating microRNA-30c/ATG5 axis in gastric cancer

RSC Advances ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 4233-4233
Author(s):  
Laura Fisher
Keyword(s):  
Gastric Cancer ◽  
Non Coding Rna ◽  
Long Non Coding Rna

Retraction of ‘Long non-coding RNA XIST promotes proliferation, autophagy and inhibits apoptosis by regulating microRNA-30c/ATG5 axis in gastric cancer’ by Mingjian Liu et al., RSC Adv., 2018, 8, 37508–37517, DOI: 10.1039/C8RA07852A.

scholarly journals Retraction: Long non-coding RNA GACAT1 alleviates doxorubicin and vincristine resistance through a PTEN/AKT/mTOR/S6K1 regulatory pathway in gastric cancer

RSC Advances ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 5000-5000
Author(s):  
Laura Fisher
Keyword(s):  
Gastric Cancer ◽  
Regulatory Pathway ◽  
Non Coding Rna ◽  
Long Non Coding Rna

Retraction of ‘Long non-coding RNA GACAT1 alleviates doxorubicin and vincristine resistance through a PTEN/AKT/mTOR/S6K1 regulatory pathway in gastric cancer’ by Hengxuan Ding et al., RSC Adv., 2019, 9, 8048–8055, DOI: 10.1039/C8RA10030F.

scholarly journals Long non‐coding RNA KCNQ1OT1 promotes the progression of gastric cancer via the miR‐145‐5p/ARF6 axis

2021 ◽  
Author(s):  
Xiongdong Zhong ◽  
Xiaoyan Wen ◽  
Lei Chen ◽  
Ni Gu ◽  
Xianchang Yu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Non Coding Rna ◽  
Long Non Coding Rna
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