scholarly journals The miR-1224-5p/ELF3 Axis Regulates Malignant Behaviors of Pancreatic Cancer via PI3K/AKT/Notch Signaling Pathways

2020 ◽  
Vol Volume 13 ◽  
pp. 3449-3466 ◽  
Author(s):  
Lingming Kong ◽  
Peng Liu ◽  
Mingjun Zheng ◽  
Zhongpeng Wang ◽  
Yang Gao ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Notch Signaling ◽  
Signaling Pathways

scholarly journals Crosstalk between the canonical NF-κB and Notch signaling pathways inhibits Pparγ expression and promotes pancreatic cancer progression in mice

2011 ◽  
Vol 121 (12) ◽  
pp. 4685-4699 ◽  
Author(s):  
Eleni Maniati ◽  
Maud Bossard ◽  
Natalie Cook ◽  
Juliana B. Candido ◽  
Nia Emami-Shahri ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Notch Signaling ◽  
Signaling Pathways ◽  
Cancer Progression ◽  
Pparγ Expression

scholarly journals Dominant Enhancers of Egfr in Drosophila melanogaster: Genetic Links Between the Notch and Egfr Signaling Pathways

Genetics ◽  
1997 ◽  
Vol 147 (3) ◽  
pp. 1139-1153 ◽  
Author(s):  
James V Price ◽  
Edward D Savenye ◽  
David Lum ◽  
Ashton Breitkreutz
Keyword(s):  
Notch Signaling ◽  
Signaling Pathways ◽  
Growth Factor Receptor ◽  
Compound Eyes ◽  
Egfr Signaling ◽  
Wing Vein ◽  
Developmental Context ◽  
Epidermal Growth ◽  
Hypomorphic Alleles ◽  
Complex Signaling

The Drosophila epidermal growth factor receptor (EGFR) is a key component of a complex signaling pathway that participates in multiple developmental processes. We have performed and F1 screen for mutations that cause dominant enhancement of wing vein phenotypes associated with mutations in Egfr. With this screen, we have recovered mutations in Hairless (H), vein, groucho (gro), and three apparently novel loci. All of the E(Egfr)s we have identified show dominant interactions in transheterozygous combinations with each other and with alleles of N or Su(H), suggesting that they are involved in cross-talk between the N and EGFR signaling pathways. Further examination of the phenotypic interactions between Egfr, H, and gro revealed that reductions in Egfr activity enhanced both the bristle loss associated with H mutations, and the bristle hyperplasia and ocellar hypertrophy associated with gro mutations. Double mutant combinations of Egfr and gro hypomorphic alleles led to the formation of ectopic compound eyes in a dosage sensitive manner. Our findings suggest that these E(Egfr)s represent links between the Egfr and Notch signaling pathways, and that Egfr activity can either promote or suppress Notch signaling, depending on its developmental context.

scholarly journals Mesenchymal stem cells regulate maintenance of neural stem cells through VEGFR2 and Notch signaling pathways

Cell Research ◽  
2008 ◽  
Vol 18 (S1) ◽  
pp. S59-S59
Author(s):  
Zhifeng Deng ◽  
Zhumin Liu ◽  
Wei Tu ◽  
Yang Wang ◽  
Yuanlei Lou
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Neural Stem Cells ◽  
Notch Signaling ◽  
Signaling Pathways

Associations of Kras and Hedgehog signaling pathways and their role in pancreatic cancer

Pancreatology ◽  
2014 ◽  
Vol 14 (3) ◽  
pp. S68
Author(s):  
Beatrice Mohelnikova-Duchonova ◽  
Veronika Brynychova ◽  
Ivana Ihnatova ◽  
Martin Oliverius ◽  
Jan Hlavsa ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Signaling Pathways ◽  
Hedgehog Signaling

MiRNA expression analysis during normal zebrafish development and following inhibition of the Hedgehog and Notch signaling pathways

2007 ◽  
Vol 236 (8) ◽  
pp. 2172-2180 ◽  
Author(s):  
Elizabeth J. Thatcher ◽  
Alex S. Flynt ◽  
Nan Li ◽  
Jonathan R. Patton ◽  
James G. Patton
Keyword(s):  
Notch Signaling ◽  
Signaling Pathways ◽  
Expression Analysis ◽  
Mirna Expression ◽  
Zebrafish Development
Sign in / Sign up

Export Citation Format

Share Document